Implantable microsystems for personalised anticancer therapy

Jamie R.K. Marland, Ewen O. Blair, Brian W. Flynn, Eva González-Fernández, Liyu Huang, Ian H. Kunkler, Stewart Smith, Matteo Staderini, Andreas Tsiamis, Carol Ward, Alan F. Murray

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

Abstract

The Implantable Microsystems for Personalised Anti-Cancer Therapy (IMPACT) project aims to produce an implantable wireless sensor device for monitoring tumour physiology. Real-time measurements will be used to improve radiotherapy by allowing treatment to be responsively delivered at the most effective time and location. We are developing miniaturised microfabricated sensors for measuring local oxygen concentration and pH within the tumour, using technologies that are amenable to integration on CMOS. In addition, we have established proof of concept for a range of electrochemical biosensors that can respond to enzyme biomarkers. Together these sensors will allow comprehensive monitoring of tissue physiology before and after radiotherapy treatment. For clinical use, the complete system will be equipped with circuits for wireless power and communications and packaged in biocompatible materials. This is a very challenging application for sensors integrated on CMOS. Here we provide a brief background to medical aspects of the work and describe our progress towards solving the engineering challenges it has presented.
LanguageEnglish
Title of host publicationCMOS Circuits for Biological Sensing and Processing
Place of PublicationCham, Switzerland
Pages259-286
Number of pages28
DOIs
Publication statusPublished - 18 Nov 2017

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Microsystems
Sensors
Physiology
Radiotherapy
Tumors
Monitoring
Biomarkers
Time measurement
Biosensors
Biomaterials
Enzymes
Tissue
Oxygen
Networks (circuits)
Communication

Keywords

  • microsystems
  • CMOS
  • implantable sensors
  • biosensor
  • biocompatible packaging
  • wireless power
  • hypoxia

Cite this

Marland, J. R. K., Blair, E. O., Flynn, B. W., González-Fernández, E., Huang, L., Kunkler, I. H., ... Murray, A. F. (2017). Implantable microsystems for personalised anticancer therapy. In CMOS Circuits for Biological Sensing and Processing (pp. 259-286). Cham, Switzerland. https://doi.org/10.1007/978-3-319-67723-1_11
Marland, Jamie R.K. ; Blair, Ewen O. ; Flynn, Brian W. ; González-Fernández, Eva ; Huang, Liyu ; Kunkler, Ian H. ; Smith, Stewart ; Staderini, Matteo ; Tsiamis, Andreas ; Ward, Carol ; Murray, Alan F. / Implantable microsystems for personalised anticancer therapy. CMOS Circuits for Biological Sensing and Processing. Cham, Switzerland, 2017. pp. 259-286
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Marland, JRK, Blair, EO, Flynn, BW, González-Fernández, E, Huang, L, Kunkler, IH, Smith, S, Staderini, M, Tsiamis, A, Ward, C & Murray, AF 2017, Implantable microsystems for personalised anticancer therapy. in CMOS Circuits for Biological Sensing and Processing. Cham, Switzerland, pp. 259-286. https://doi.org/10.1007/978-3-319-67723-1_11

Implantable microsystems for personalised anticancer therapy. / Marland, Jamie R.K.; Blair, Ewen O.; Flynn, Brian W.; González-Fernández, Eva; Huang, Liyu; Kunkler, Ian H.; Smith, Stewart; Staderini, Matteo; Tsiamis, Andreas; Ward, Carol; Murray, Alan F.

CMOS Circuits for Biological Sensing and Processing. Cham, Switzerland, 2017. p. 259-286.

Research output: Chapter in Book/Report/Conference proceedingChapter

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Marland JRK, Blair EO, Flynn BW, González-Fernández E, Huang L, Kunkler IH et al. Implantable microsystems for personalised anticancer therapy. In CMOS Circuits for Biological Sensing and Processing. Cham, Switzerland. 2017. p. 259-286 https://doi.org/10.1007/978-3-319-67723-1_11