Impairment of gradual muscle adjustment during wrist circumduction in Parkinson's disease

Carolien M. Toxopeus, Bauke M. de Jong, Gopal Valsan, Bernard A. Conway, Johannes H. van der Hoeven, Klaus L. Leenders, Natasha M. Maurits

    Research output: Contribution to journalArticle

    5 Citations (Scopus)

    Abstract

    Purposeful movements are attained by gradually adjusted activity of opposite muscles, or synergists. This requires a motor system that adequately modulates initiation and inhibition of movement and selectively activates the appropriate muscles. In patients with Parkinson's disease (PD) initiation and inhibition of movements are impaired which may manifest itself in e.g. difficulty to start and stop walking. At single-joint level, impaired movement initiation is further accompanied by insufficient inhibition of antagonist muscle activity. As the motor symptoms in PD primarily result from cerebral dysfunction, quantitative investigation of gradually adjusted muscle activity during execution of purposeful movement is a first step to gain more insight in the link between impaired modulation of initiation and inhibition at the levels of (i) cerebrally coded task performance and (ii) final execution by the musculoskeletal system. To that end, the present study investigated changes in gradual adjustment of muscle synergists using a manipulandum that enabled standardized smooth movement by continuous wrist circumduction. Differences between PD patients (N = 15, off-medication) and healthy subjects (N = 16) concerning the relation between muscle activity and movement performance in these groups were assessed using kinematic and electromyographic (EMG) recordings. The variability in the extent to which a particular muscle was active during wrist circumduction - defined as muscle activity differentiation - was quantified by EMG. We demonstrated that more differentiated muscle activity indeed correlated positively with improved movement performance, i.e. higher movement speed and increased smoothness of movement. Additionally, patients employed a less differentiated muscle activity pattern than healthy subjects. These specific changes during wrist circumduction imply that patients have a decreased ability to gradually adjust muscles causing a decline in movement performance. We propose that less differentiated muscle use in PD patients reflects impaired control of modulated initiation and inhibition due to decreased ability to selectively and jointly activate muscles.

    LanguageEnglish
    Article numbere24572
    Pages-
    Number of pages11
    JournalPLoS One
    Volume6
    Issue number9
    DOIs
    Publication statusPublished - 2 Sep 2011

    Fingerprint

    Social Adjustment
    Parkinson disease
    Wrist
    Parkinson Disease
    Muscle
    Muscles
    muscles
    synergists
    Aptitude
    Healthy Volunteers
    Musculoskeletal system
    musculoskeletal system
    Musculoskeletal System
    Task Performance and Analysis
    kinematics
    Biomechanical Phenomena
    joints (animal)
    walking
    signs and symptoms (animals and humans)
    drug therapy

    Keywords

    • basal ganglia
    • tracking movements
    • aiming movements
    • elderly adults
    • arm movements
    • inhibition
    • cerebellum
    • disorders
    • submovements
    • disruptions

    Cite this

    Toxopeus, C. M., de Jong, B. M., Valsan, G., Conway, B. A., van der Hoeven, J. H., Leenders, K. L., & Maurits, N. M. (2011). Impairment of gradual muscle adjustment during wrist circumduction in Parkinson's disease. PLoS One, 6(9), -. [e24572]. https://doi.org/10.1371/journal.pone.0024572
    Toxopeus, Carolien M. ; de Jong, Bauke M. ; Valsan, Gopal ; Conway, Bernard A. ; van der Hoeven, Johannes H. ; Leenders, Klaus L. ; Maurits, Natasha M. / Impairment of gradual muscle adjustment during wrist circumduction in Parkinson's disease. In: PLoS One. 2011 ; Vol. 6, No. 9. pp. -.
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    Toxopeus, CM, de Jong, BM, Valsan, G, Conway, BA, van der Hoeven, JH, Leenders, KL & Maurits, NM 2011, 'Impairment of gradual muscle adjustment during wrist circumduction in Parkinson's disease' PLoS One, vol. 6, no. 9, e24572, pp. -. https://doi.org/10.1371/journal.pone.0024572

    Impairment of gradual muscle adjustment during wrist circumduction in Parkinson's disease. / Toxopeus, Carolien M.; de Jong, Bauke M.; Valsan, Gopal; Conway, Bernard A.; van der Hoeven, Johannes H.; Leenders, Klaus L.; Maurits, Natasha M.

    In: PLoS One, Vol. 6, No. 9, e24572, 02.09.2011, p. -.

    Research output: Contribution to journalArticle

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    Toxopeus CM, de Jong BM, Valsan G, Conway BA, van der Hoeven JH, Leenders KL et al. Impairment of gradual muscle adjustment during wrist circumduction in Parkinson's disease. PLoS One. 2011 Sep 2;6(9):-. e24572. https://doi.org/10.1371/journal.pone.0024572