Impaired transmission in the corticospinal tract and gait disability in spinal cord injured persons

D. Barthélemy, M. Willerslev-Olsen, Henrik Lundell, B.A. Conway, H. Knudsen, F. Biering-Sørensen, J.B. Nielsen

    Research output: Contribution to journalArticle

    52 Citations (Scopus)

    Abstract

    Rehabilitation following spinal cord injury is likely to depend on recovery of corticospinal systems. Here we investigate whether transmission in the corticospinal tract may explain foot drop (inability to dorsiflex ankle) in persons with spinal cord lesion. The study was performed in 24 persons with incomplete spinal cord lesion (C1 to L1) and 15 healthy controls. Coherence in the 10- to 20-Hz frequency band between paired tibialis anterior muscle (TA) electromyographic recordings obtained in the swing phase of walking, which was taken as a measure of motor unit synchronization. It was significantly correlated with the degree of foot drop, as measured by toe elevation and ankle angle excursion in the first part of swing. Transcranial magnetic stimulation was used to elicit motor-evoked potentials (MEPs) in the TA. The amplitude of the MEPs at rest and their latency during contraction were correlated to the degree of foot drop. Spinal cord injured participants who exhibited a large foot drop had little or no MEP at rest in the TA muscle and had little or no coherence in the same muscle during walking. Gait speed was correlated to foot drop, and was the lowest in participants with no MEP at rest. The data confirm that transmission in the corticospinal tract is of importance for lifting the foot during the swing phase of human gait.
    LanguageEnglish
    Pages1167-1176
    Number of pages10
    JournalJournal of Neurophysiology
    Volume104
    Issue number2
    DOIs
    Publication statusPublished - 1 Aug 2010

    Fingerprint

    Pyramidal Tracts
    Gait
    Foot
    Motor Evoked Potentials
    Spinal Cord
    Muscles
    Ankle
    Walking
    Transcranial Magnetic Stimulation
    Toes
    Spinal Cord Injuries
    Rehabilitation

    Keywords

    • gait
    • gait disability
    • spinal injury
    • spinal cord
    • corticospinal tract

    Cite this

    Barthélemy, D., Willerslev-Olsen, M., Lundell, H., Conway, B. A., Knudsen, H., Biering-Sørensen, F., & Nielsen, J. B. (2010). Impaired transmission in the corticospinal tract and gait disability in spinal cord injured persons. Journal of Neurophysiology, 104(2), 1167-1176. https://doi.org/10.1152/jn.00382.2010
    Barthélemy, D. ; Willerslev-Olsen, M. ; Lundell, Henrik ; Conway, B.A. ; Knudsen, H. ; Biering-Sørensen, F. ; Nielsen, J.B. / Impaired transmission in the corticospinal tract and gait disability in spinal cord injured persons. In: Journal of Neurophysiology. 2010 ; Vol. 104, No. 2. pp. 1167-1176.
    @article{7ae5d0ffda224f22a568519a2ec25283,
    title = "Impaired transmission in the corticospinal tract and gait disability in spinal cord injured persons",
    abstract = "Rehabilitation following spinal cord injury is likely to depend on recovery of corticospinal systems. Here we investigate whether transmission in the corticospinal tract may explain foot drop (inability to dorsiflex ankle) in persons with spinal cord lesion. The study was performed in 24 persons with incomplete spinal cord lesion (C1 to L1) and 15 healthy controls. Coherence in the 10- to 20-Hz frequency band between paired tibialis anterior muscle (TA) electromyographic recordings obtained in the swing phase of walking, which was taken as a measure of motor unit synchronization. It was significantly correlated with the degree of foot drop, as measured by toe elevation and ankle angle excursion in the first part of swing. Transcranial magnetic stimulation was used to elicit motor-evoked potentials (MEPs) in the TA. The amplitude of the MEPs at rest and their latency during contraction were correlated to the degree of foot drop. Spinal cord injured participants who exhibited a large foot drop had little or no MEP at rest in the TA muscle and had little or no coherence in the same muscle during walking. Gait speed was correlated to foot drop, and was the lowest in participants with no MEP at rest. The data confirm that transmission in the corticospinal tract is of importance for lifting the foot during the swing phase of human gait.",
    keywords = "gait, gait disability, spinal injury, spinal cord, corticospinal tract",
    author = "D. Barth{\'e}lemy and M. Willerslev-Olsen and Henrik Lundell and B.A. Conway and H. Knudsen and F. Biering-S{\o}rensen and J.B. Nielsen",
    year = "2010",
    month = "8",
    day = "1",
    doi = "10.1152/jn.00382.2010",
    language = "English",
    volume = "104",
    pages = "1167--1176",
    journal = "Journal of Neurophysiology",
    issn = "0022-3077",
    publisher = "American Physiological Society",
    number = "2",

    }

    Barthélemy, D, Willerslev-Olsen, M, Lundell, H, Conway, BA, Knudsen, H, Biering-Sørensen, F & Nielsen, JB 2010, 'Impaired transmission in the corticospinal tract and gait disability in spinal cord injured persons' Journal of Neurophysiology, vol. 104, no. 2, pp. 1167-1176. https://doi.org/10.1152/jn.00382.2010

    Impaired transmission in the corticospinal tract and gait disability in spinal cord injured persons. / Barthélemy, D.; Willerslev-Olsen, M.; Lundell, Henrik; Conway, B.A.; Knudsen, H.; Biering-Sørensen, F.; Nielsen, J.B.

    In: Journal of Neurophysiology, Vol. 104, No. 2, 01.08.2010, p. 1167-1176.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Impaired transmission in the corticospinal tract and gait disability in spinal cord injured persons

    AU - Barthélemy, D.

    AU - Willerslev-Olsen, M.

    AU - Lundell, Henrik

    AU - Conway, B.A.

    AU - Knudsen, H.

    AU - Biering-Sørensen, F.

    AU - Nielsen, J.B.

    PY - 2010/8/1

    Y1 - 2010/8/1

    N2 - Rehabilitation following spinal cord injury is likely to depend on recovery of corticospinal systems. Here we investigate whether transmission in the corticospinal tract may explain foot drop (inability to dorsiflex ankle) in persons with spinal cord lesion. The study was performed in 24 persons with incomplete spinal cord lesion (C1 to L1) and 15 healthy controls. Coherence in the 10- to 20-Hz frequency band between paired tibialis anterior muscle (TA) electromyographic recordings obtained in the swing phase of walking, which was taken as a measure of motor unit synchronization. It was significantly correlated with the degree of foot drop, as measured by toe elevation and ankle angle excursion in the first part of swing. Transcranial magnetic stimulation was used to elicit motor-evoked potentials (MEPs) in the TA. The amplitude of the MEPs at rest and their latency during contraction were correlated to the degree of foot drop. Spinal cord injured participants who exhibited a large foot drop had little or no MEP at rest in the TA muscle and had little or no coherence in the same muscle during walking. Gait speed was correlated to foot drop, and was the lowest in participants with no MEP at rest. The data confirm that transmission in the corticospinal tract is of importance for lifting the foot during the swing phase of human gait.

    AB - Rehabilitation following spinal cord injury is likely to depend on recovery of corticospinal systems. Here we investigate whether transmission in the corticospinal tract may explain foot drop (inability to dorsiflex ankle) in persons with spinal cord lesion. The study was performed in 24 persons with incomplete spinal cord lesion (C1 to L1) and 15 healthy controls. Coherence in the 10- to 20-Hz frequency band between paired tibialis anterior muscle (TA) electromyographic recordings obtained in the swing phase of walking, which was taken as a measure of motor unit synchronization. It was significantly correlated with the degree of foot drop, as measured by toe elevation and ankle angle excursion in the first part of swing. Transcranial magnetic stimulation was used to elicit motor-evoked potentials (MEPs) in the TA. The amplitude of the MEPs at rest and their latency during contraction were correlated to the degree of foot drop. Spinal cord injured participants who exhibited a large foot drop had little or no MEP at rest in the TA muscle and had little or no coherence in the same muscle during walking. Gait speed was correlated to foot drop, and was the lowest in participants with no MEP at rest. The data confirm that transmission in the corticospinal tract is of importance for lifting the foot during the swing phase of human gait.

    KW - gait

    KW - gait disability

    KW - spinal injury

    KW - spinal cord

    KW - corticospinal tract

    UR - http://www.ncbi.nlm.nih.gov/pubmed/20554839

    UR - http://jn.physiology.org/content/104/2/1167.abstract

    U2 - 10.1152/jn.00382.2010

    DO - 10.1152/jn.00382.2010

    M3 - Article

    VL - 104

    SP - 1167

    EP - 1176

    JO - Journal of Neurophysiology

    T2 - Journal of Neurophysiology

    JF - Journal of Neurophysiology

    SN - 0022-3077

    IS - 2

    ER -

    Barthélemy D, Willerslev-Olsen M, Lundell H, Conway BA, Knudsen H, Biering-Sørensen F et al. Impaired transmission in the corticospinal tract and gait disability in spinal cord injured persons. Journal of Neurophysiology. 2010 Aug 1;104(2):1167-1176. https://doi.org/10.1152/jn.00382.2010