Impact of the flavonoid quercetin on beta-amyloid aggregation revealed by intrinsic fluorescence

Abeer Alghamdi; David J.S. Birch; Vladislav Vyshemirsky; Olaf J. Rolinski

doi:10.1021/acs.jpcb.2c02763

Impact of the flavonoid quercetin on beta-amyloid aggregation revealed by intrinsic fluorescence

Abeer Alghamdi, David J.S. Birch, Vladislav Vyshemirsky, Olaf J. Rolinski

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Abstract

We report the effects of quercetin, a flavonoid present in the human diet, on early stage beta-amyloid (Aβ) aggregation, a seminal event in Alzheimer's disease. Molecular level changes in Aβ arrangements are monitored by time-resolved emission spectral (TRES) measurements of the fluorescence of Aβ's single tyrosine intrinsic fluorophore (Tyr). The results suggest that quercetin binds β-amyloid oligomers at early stages of their aggregation, which leads to the formation of modified oligomers and hinders the creation of β-sheet structures, potentially preventing the onset of Alzheimer's disease.

Original language	English
Pages (from-to)	7229-7237
Number of pages	9
Journal	Journal of Physical Chemistry B
Volume	126
Issue number	38
Early online date	19 Sept 2022
DOIs	https://doi.org/10.1021/acs.jpcb.2c02763
Publication status	Published - 29 Sept 2022

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

flavonoid
Quercetin
early stage beta-amyloid (Aβ) aggregation
time-resolved emission spectral (TRES)
fluorescence
single tyrosine intrinsic fluorophore (Tyr)

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10.1021/acs.jpcb.2c02763Licence: CC BY 4.0

Alghamdi-etal-JPCB-2022-Impact-of-the-flavonoid-quercetin-on-beta-amyloid-aggregationFinal published version, 4.07 MBLicence: CC BY 4.0

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title = "Impact of the flavonoid quercetin on beta-amyloid aggregation revealed by intrinsic fluorescence",

abstract = "We report the effects of quercetin, a flavonoid present in the human diet, on early stage beta-amyloid (Aβ) aggregation, a seminal event in Alzheimer's disease. Molecular level changes in Aβ arrangements are monitored by time-resolved emission spectral (TRES) measurements of the fluorescence of Aβ's single tyrosine intrinsic fluorophore (Tyr). The results suggest that quercetin binds β-amyloid oligomers at early stages of their aggregation, which leads to the formation of modified oligomers and hinders the creation of β-sheet structures, potentially preventing the onset of Alzheimer's disease.",

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T1 - Impact of the flavonoid quercetin on beta-amyloid aggregation revealed by intrinsic fluorescence

AU - Alghamdi, Abeer

AU - Birch, David J.S.

AU - Vyshemirsky, Vladislav

AU - Rolinski, Olaf J.

PY - 2022/9/29

Y1 - 2022/9/29

N2 - We report the effects of quercetin, a flavonoid present in the human diet, on early stage beta-amyloid (Aβ) aggregation, a seminal event in Alzheimer's disease. Molecular level changes in Aβ arrangements are monitored by time-resolved emission spectral (TRES) measurements of the fluorescence of Aβ's single tyrosine intrinsic fluorophore (Tyr). The results suggest that quercetin binds β-amyloid oligomers at early stages of their aggregation, which leads to the formation of modified oligomers and hinders the creation of β-sheet structures, potentially preventing the onset of Alzheimer's disease.

AB - We report the effects of quercetin, a flavonoid present in the human diet, on early stage beta-amyloid (Aβ) aggregation, a seminal event in Alzheimer's disease. Molecular level changes in Aβ arrangements are monitored by time-resolved emission spectral (TRES) measurements of the fluorescence of Aβ's single tyrosine intrinsic fluorophore (Tyr). The results suggest that quercetin binds β-amyloid oligomers at early stages of their aggregation, which leads to the formation of modified oligomers and hinders the creation of β-sheet structures, potentially preventing the onset of Alzheimer's disease.

KW - flavonoid

KW - Quercetin

KW - early stage beta-amyloid (Aβ) aggregation

KW - time-resolved emission spectral (TRES)

KW - fluorescence

KW - single tyrosine intrinsic fluorophore (Tyr)

U2 - 10.1021/acs.jpcb.2c02763

DO - 10.1021/acs.jpcb.2c02763

M3 - Article

SN - 1520-6106

VL - 126

SP - 7229

EP - 7237

JO - Journal of Physical Chemistry B

JF - Journal of Physical Chemistry B

IS - 38

ER -

Impact of the flavonoid quercetin on beta-amyloid aggregation revealed by intrinsic fluorescence

Abstract

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Keywords

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