Projects per year
Silk can be processed into a broad spectrum of material formats and is explored for a wide range of medical applications, including hydrogels for wound care. The current paradigm is that solution-stable silk fibroin in the hydrogels is responsible for their therapeutic response in wound healing. Here, we generated physically cross-linked silk fibroin hydrogels with tuned secondary structure and examined their ability to influence their biological response by leaching silk fibroin. Significantly more silk fibroin leached from hydrogels with an amorphous silk fibroin structure than with a beta sheet–rich silk fibroin structure, although all hydrogels leached silk fibroin. The leached silk was biologically active, as it induced vitro chemokinesis and faster scratch assay wound healing by activating receptor tyrosine kinases. Overall, these effects are desirable for wound management and show the promise of silk fibroin and hydrogel leaching in the wider healthcare setting.
|Number of pages||12|
|Publication status||Published - 8 Mar 2022|
- silk fibroin
- soluble silk
- wound healing
FingerprintDive into the research topics of 'Impact of silk hydrogel secondary structure on hydrogel formation, silk leaching and in vitro response'. Together they form a unique fingerprint.
- 1 Finished
EPSRC Centre for Doctoral Training in Medical Devices and Health Technologies
Connolly, P., Black, R. A., Conway, B. A., Graham, D., Hunter, I., Mathieson, K., Ulijn, R. & Winn, P.
EPSRC (Engineering and Physical Sciences Research Council)
1/04/14 → 30/09/22
Project: Research - Studentship
Data for: "Impact of Silk Hydrogel Secondary Structure on Hydrogel Formation, Silk Leaching and In Vitro Response"
Egan, G. (Creator), Matthew, S. (Creator), Phuagkhaopong, S. (Creator), Connolly, P. (Supervisor) & Seib, P. (Supervisor), University of Strathclyde, 11 Mar 2022