Impact of molecular speciation on crystal nucleation in polymorphic systems: the conundrum of gamma glycine and molecular 'self poisoning'

Christopher S Towler, Roger J Davey, Robert W Lancaster, Chris J. Price

Research output: Contribution to journalArticle

152 Citations (Scopus)

Abstract

The polymorphism of the simple amino acid glycine has been known for almost a century. It is also known that in aqueous solutions, at the isoelectric point (pI 5.9), the metastable alpha polymorph crystallizes, while the stable gamma form of glycine only nucleates at high and low pH. Despite the importance of understanding the process by which crystals nucleate, the solution and solid-state chemistry underlying this simple observation have never been explored. In this contribution, we have combined solution chemistry, crystallization, and crystallographic data to investigate the mechanisms by which this effect occurs. It is concluded that solution speciation and the consequent interactions between charged species and developing crystal nuclei determine the structural outcome of the crystallization process.
Original languageEnglish
Pages (from-to)13347-13353
Number of pages7
JournalJournal of the American Chemical Society
Volume126
Issue number41
Early online date24 Sep 2004
DOIs
Publication statusPublished - 20 Oct 2004

Keywords

  • speciation
  • polymorphism
  • glycine

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