Impact of free-living pattern of sedentary behaviour on intra-day glucose regulation in type 2 diabetes

Aye C. Paing; Kathryn A. McMillan; Alison F. Kirk; Andrew Collier; Allan Hewitt; Sebastien F.M. Chastin

doi:10.1007/s00421-019-04261-z

Impact of free-living pattern of sedentary behaviour on intra-day glucose regulation in type 2 diabetes

Aye C. Paing^*, Kathryn A. McMillan, Alison F. Kirk, Andrew Collier, Allan Hewitt, Sebastien F.M. Chastin

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Purpose: To investigate how the pattern of sedentary behaviour affects intra-day glucose regulation in type 2 diabetes. Methods: This intensive longitudinal study was conducted in 37 participants with type 2 diabetes (age, 62.8 ± 10.5 years). Glucose and sedentary behaviour/physical activity were assessed with a continuous glucose monitoring (Abbott FreeStyle Libre) and an activity monitor (activPAL3) for 14 days. Multiple regression models with generalised estimating equations (GEEs) approach were used to assess the associations of sedentary time and breaks in sedentary time with pre-breakfast glucose, pre-lunch glucose, pre-dinner glucose, post-breakfast glucose, post-lunch glucose, post-dinner glucose, bedtime glucose, the dawn phenomenon, time in target glucose range (TIR, glucose 3.9–10 mmol/L) and time above target glucose range (TAR, glucose > 10 mmol/L). Results: Sedentary time was associated with higher pre-breakfast glucose (p = 0.001), pre-dinner glucose (p < 0.001), post-lunch glucose (p = 0.005), post-dinner glucose (p = 0.013) and the dawn phenomenon (p < 0.001). Breaks in sedentary time were associated with lower pre-breakfast glucose (p = 0.023), pre-dinner glucose (p = 0.023), post-breakfast glucose (p < 0.001) and the dawn phenomenon (p = 0.004). The association between sedentary time and less TIR (p = 0.022) and the association between breaks in sedentary time and more TIR (p = 0.001) were also observed. Conclusions: Reducing sedentary time and promoting breaks in sedentary time could be clinically relevant to improve intra-day glucose regulation in type 2 diabetes.

Original language	English
Pages (from-to)	171-179
Number of pages	9
Journal	European Journal of Applied Physiology
Volume	120
Early online date	8 Nov 2019
DOIs	https://doi.org/10.1007/s00421-019-04261-z
Publication status	Published - 31 Jan 2020

Funding

This work was supported by School of Psychological Sciences and Health, University of Strathclyde, UK; PAL technologies Ltd (Glasgow, UK) and School of Health and Life-Sciences, Glasgow Caledonian University, UK. The funding agencies did not play any role in preparing and writing up manuscript and making a decision to submit manuscript. The authors would like to thank KAM who put significant efforts on recruitment of participants. The authors also thank participants who volunteered and devoted their time to the study.

Keywords

breaks in sedentary time
glucose targets
glycaemic control
physical activity
sedentary behaviour
type 2 diabetes

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Paing-etal-EJAP2019-Impact-of-free-living-pattern-of-sedentary-behaviour-on-intra-day-glucoseFinal published version, 406 KBLicence: CC BY 4.0

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@article{80760da8d6e14fdeac4b4884d08a145d,

title = "Impact of free-living pattern of sedentary behaviour on intra-day glucose regulation in type 2 diabetes",

abstract = "Purpose: To investigate how the pattern of sedentary behaviour affects intra-day glucose regulation in type 2 diabetes. Methods: This intensive longitudinal study was conducted in 37 participants with type 2 diabetes (age, 62.8 ± 10.5 years). Glucose and sedentary behaviour/physical activity were assessed with a continuous glucose monitoring (Abbott FreeStyle Libre) and an activity monitor (activPAL3) for 14 days. Multiple regression models with generalised estimating equations (GEEs) approach were used to assess the associations of sedentary time and breaks in sedentary time with pre-breakfast glucose, pre-lunch glucose, pre-dinner glucose, post-breakfast glucose, post-lunch glucose, post-dinner glucose, bedtime glucose, the dawn phenomenon, time in target glucose range (TIR, glucose 3.9–10 mmol/L) and time above target glucose range (TAR, glucose > 10 mmol/L). Results: Sedentary time was associated with higher pre-breakfast glucose (p = 0.001), pre-dinner glucose (p < 0.001), post-lunch glucose (p = 0.005), post-dinner glucose (p = 0.013) and the dawn phenomenon (p < 0.001). Breaks in sedentary time were associated with lower pre-breakfast glucose (p = 0.023), pre-dinner glucose (p = 0.023), post-breakfast glucose (p < 0.001) and the dawn phenomenon (p = 0.004). The association between sedentary time and less TIR (p = 0.022) and the association between breaks in sedentary time and more TIR (p = 0.001) were also observed. Conclusions: Reducing sedentary time and promoting breaks in sedentary time could be clinically relevant to improve intra-day glucose regulation in type 2 diabetes.",

keywords = "breaks in sedentary time, glucose targets, glycaemic control, physical activity, sedentary behaviour, type 2 diabetes",

author = "Paing, {Aye C.} and McMillan, {Kathryn A.} and Kirk, {Alison F.} and Andrew Collier and Allan Hewitt and Chastin, {Sebastien F.M.}",

year = "2020",

month = jan,

day = "31",

doi = "10.1007/s00421-019-04261-z",

language = "English",

volume = "120",

pages = "171--179",

journal = "European Journal of Applied Physiology",

issn = "1439-6319",

publisher = "Springer Science and Business Media Deutschland GmbH",

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T1 - Impact of free-living pattern of sedentary behaviour on intra-day glucose regulation in type 2 diabetes

AU - Paing, Aye C.

AU - McMillan, Kathryn A.

AU - Kirk, Alison F.

AU - Collier, Andrew

AU - Hewitt, Allan

AU - Chastin, Sebastien F.M.

PY - 2020/1/31

Y1 - 2020/1/31

N2 - Purpose: To investigate how the pattern of sedentary behaviour affects intra-day glucose regulation in type 2 diabetes. Methods: This intensive longitudinal study was conducted in 37 participants with type 2 diabetes (age, 62.8 ± 10.5 years). Glucose and sedentary behaviour/physical activity were assessed with a continuous glucose monitoring (Abbott FreeStyle Libre) and an activity monitor (activPAL3) for 14 days. Multiple regression models with generalised estimating equations (GEEs) approach were used to assess the associations of sedentary time and breaks in sedentary time with pre-breakfast glucose, pre-lunch glucose, pre-dinner glucose, post-breakfast glucose, post-lunch glucose, post-dinner glucose, bedtime glucose, the dawn phenomenon, time in target glucose range (TIR, glucose 3.9–10 mmol/L) and time above target glucose range (TAR, glucose > 10 mmol/L). Results: Sedentary time was associated with higher pre-breakfast glucose (p = 0.001), pre-dinner glucose (p < 0.001), post-lunch glucose (p = 0.005), post-dinner glucose (p = 0.013) and the dawn phenomenon (p < 0.001). Breaks in sedentary time were associated with lower pre-breakfast glucose (p = 0.023), pre-dinner glucose (p = 0.023), post-breakfast glucose (p < 0.001) and the dawn phenomenon (p = 0.004). The association between sedentary time and less TIR (p = 0.022) and the association between breaks in sedentary time and more TIR (p = 0.001) were also observed. Conclusions: Reducing sedentary time and promoting breaks in sedentary time could be clinically relevant to improve intra-day glucose regulation in type 2 diabetes.

AB - Purpose: To investigate how the pattern of sedentary behaviour affects intra-day glucose regulation in type 2 diabetes. Methods: This intensive longitudinal study was conducted in 37 participants with type 2 diabetes (age, 62.8 ± 10.5 years). Glucose and sedentary behaviour/physical activity were assessed with a continuous glucose monitoring (Abbott FreeStyle Libre) and an activity monitor (activPAL3) for 14 days. Multiple regression models with generalised estimating equations (GEEs) approach were used to assess the associations of sedentary time and breaks in sedentary time with pre-breakfast glucose, pre-lunch glucose, pre-dinner glucose, post-breakfast glucose, post-lunch glucose, post-dinner glucose, bedtime glucose, the dawn phenomenon, time in target glucose range (TIR, glucose 3.9–10 mmol/L) and time above target glucose range (TAR, glucose > 10 mmol/L). Results: Sedentary time was associated with higher pre-breakfast glucose (p = 0.001), pre-dinner glucose (p < 0.001), post-lunch glucose (p = 0.005), post-dinner glucose (p = 0.013) and the dawn phenomenon (p < 0.001). Breaks in sedentary time were associated with lower pre-breakfast glucose (p = 0.023), pre-dinner glucose (p = 0.023), post-breakfast glucose (p < 0.001) and the dawn phenomenon (p = 0.004). The association between sedentary time and less TIR (p = 0.022) and the association between breaks in sedentary time and more TIR (p = 0.001) were also observed. Conclusions: Reducing sedentary time and promoting breaks in sedentary time could be clinically relevant to improve intra-day glucose regulation in type 2 diabetes.

KW - breaks in sedentary time

KW - glucose targets

KW - glycaemic control

KW - physical activity

KW - sedentary behaviour

KW - type 2 diabetes

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U2 - 10.1007/s00421-019-04261-z

DO - 10.1007/s00421-019-04261-z

M3 - Article

AN - SCOPUS:85075060554

SN - 1439-6319

VL - 120

SP - 171

EP - 179

JO - European Journal of Applied Physiology

JF - European Journal of Applied Physiology

ER -

Impact of free-living pattern of sedentary behaviour on intra-day glucose regulation in type 2 diabetes

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