Impact of cigarette smoking on cancer risk in the European prospective investigation into cancer and nutrition study

Antonio Agudo; Catalina Bonet; Noémie Travier; Carlos A González; Paolo Vineis; H Bas Bueno-de-Mesquita; Dimitrios Trichopoulos; Paolo Boffetta; Françoise Clavel-Chapelon; Marie-Christine Boutron-Ruault; Rudolf Kaaks; Annekatrin Lukanova; Madlen Schütze; Heiner Boeing; Anne Tjonneland; Jytte Halkjaer; Kim Overvad; Christina C Dahm; J Ramon Quirós; María-José Sánchez; Nerea Larrañaga; Carmen Navarro; Eva Ardanaz; Kay-Tee Khaw; Nicholas J Wareham; Timothy J Key; Naomi E Allen; Antonia Trichopoulou; Pagona Lagiou; Domenico Palli; Sabina Sieri; Rosario Tumino; Salvatore Panico; Hendriek Boshuizen; Frederike L Büchner; Petra H M Peeters; Signe Borgquist; Martin Almquist; Göran Hallmans; Ingegerd Johansson; Inger T Gram; Eiliv Lund; Elisabete Weiderpass; Isabelle Romieu; Elio Riboli

doi:10.1200/JCO.2011.41.0183

Impact of cigarette smoking on cancer risk in the European prospective investigation into cancer and nutrition study

Antonio Agudo, Catalina Bonet, Noémie Travier, Carlos A González, Paolo Vineis, H Bas Bueno-de-Mesquita, Dimitrios Trichopoulos, Paolo Boffetta, Françoise Clavel-Chapelon, Marie-Christine Boutron-Ruault, Rudolf Kaaks, Annekatrin Lukanova, Madlen Schütze, Heiner Boeing, Anne Tjonneland, Jytte Halkjaer, Kim Overvad, Christina C Dahm, J Ramon Quirós, María-José SánchezNerea Larrañaga, Carmen Navarro, Eva Ardanaz, Kay-Tee Khaw, Nicholas J Wareham, Timothy J Key, Naomi E Allen, Antonia Trichopoulou, Pagona Lagiou, Domenico Palli, Sabina Sieri, Rosario Tumino, Salvatore Panico, Hendriek Boshuizen, Frederike L Büchner, Petra H M Peeters, Signe Borgquist, Martin Almquist, Göran Hallmans, Ingegerd Johansson, Inger T Gram, Eiliv Lund, Elisabete Weiderpass, Isabelle Romieu, Elio Riboli

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

130 Citations (Scopus)

Abstract

Purpose: Our aim was to assess the impact of cigarette smoking on the risk of the tumors classified by the International Agency for Research on Cancer as causally associated with smoking, referred to as tobacco-related cancers (TRC).
Methods: The study population included 441,211 participants (133,018 men and 308,193 women) from the European Prospective Investigation Into Cancer and Nutrition. We investigated 14,563 participants who developed a TRC during an average follow-up of 11 years. The impact of smoking cigarettes on cancer risk was assessed by the population attributable fraction (AFp), calculated using the adjusted hazard ratios and 95% CI for current and former smokers, plus either the prevalence of smoking among cancer cases or estimates from surveys in representative samples of the population in each country.
Results: The proportion of all TRC attributable to cigarette smoking was 34.9% (95% CI, 32.5 to 37.4) using the smoking prevalence among cases and 36.2% (95% CI, 33.7 to 38.6) using the smoking prevalence from the population. The AFp were above 80% for cancers of the lung and larynx, between 20% and 50% for most respiratory and digestive cancers and tumors from the lower urinary tract, and below 20% for the remaining TRC.
Conclusion: Using data on cancer incidence for 2008 and our AFp estimates, about 270,000 new cancer diagnoses per year can be considered attributable to cigarette smoking in the eight European countries with available data for both men and women (Italy, Spain, United Kingdom, the Netherlands, Greece, Germany, Sweden, Denmark).

Original language	English
Pages (from-to)	4550-4557
Number of pages	8
Journal	Journal of Clinical Oncology
Volume	30
Issue number	36
Early online date	19 Nov 2012
DOIs	https://doi.org/10.1200/JCO.2011.41.0183
Publication status	Published - 20 Dec 2012

Keywords

young adult
smoking
neoplasms
questionnaires
prospective studies
risk factors
humans
adult
europe
adolescent
male
female

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1200/JCO.2011.41.0183

Cite this

Agudo, A., Bonet, C., Travier, N., González, C. A., Vineis, P., Bueno-de-Mesquita, H. B., Trichopoulos, D., Boffetta, P., Clavel-Chapelon, F., Boutron-Ruault, M.-C., Kaaks, R., Lukanova, A., Schütze, M., Boeing, H., Tjonneland, A., Halkjaer, J., Overvad, K., Dahm, C. C., Quirós, J. R., ... Riboli, E. (2012). Impact of cigarette smoking on cancer risk in the European prospective investigation into cancer and nutrition study. Journal of Clinical Oncology, 30(36), 4550-4557. https://doi.org/10.1200/JCO.2011.41.0183

@article{c229a34ef0dd42b4baca34faccf04e7b,

title = "Impact of cigarette smoking on cancer risk in the European prospective investigation into cancer and nutrition study",

abstract = "Purpose: Our aim was to assess the impact of cigarette smoking on the risk of the tumors classified by the International Agency for Research on Cancer as causally associated with smoking, referred to as tobacco-related cancers (TRC).Methods: The study population included 441,211 participants (133,018 men and 308,193 women) from the European Prospective Investigation Into Cancer and Nutrition. We investigated 14,563 participants who developed a TRC during an average follow-up of 11 years. The impact of smoking cigarettes on cancer risk was assessed by the population attributable fraction (AFp), calculated using the adjusted hazard ratios and 95% CI for current and former smokers, plus either the prevalence of smoking among cancer cases or estimates from surveys in representative samples of the population in each country.Results: The proportion of all TRC attributable to cigarette smoking was 34.9% (95% CI, 32.5 to 37.4) using the smoking prevalence among cases and 36.2% (95% CI, 33.7 to 38.6) using the smoking prevalence from the population. The AFp were above 80% for cancers of the lung and larynx, between 20% and 50% for most respiratory and digestive cancers and tumors from the lower urinary tract, and below 20% for the remaining TRC.Conclusion: Using data on cancer incidence for 2008 and our AFp estimates, about 270,000 new cancer diagnoses per year can be considered attributable to cigarette smoking in the eight European countries with available data for both men and women (Italy, Spain, United Kingdom, the Netherlands, Greece, Germany, Sweden, Denmark).",

keywords = "young adult, smoking, neoplasms, questionnaires, prospective studies, risk factors, humans, adult, europe, adolescent, male, female",

author = "Antonio Agudo and Catalina Bonet and No{\'e}mie Travier and Gonz{\'a}lez, {Carlos A} and Paolo Vineis and Bueno-de-Mesquita, {H Bas} and Dimitrios Trichopoulos and Paolo Boffetta and Fran{\c c}oise Clavel-Chapelon and Marie-Christine Boutron-Ruault and Rudolf Kaaks and Annekatrin Lukanova and Madlen Sch{\"u}tze and Heiner Boeing and Anne Tjonneland and Jytte Halkjaer and Kim Overvad and Dahm, {Christina C} and Quir{\'o}s, {J Ramon} and Mar{\'i}a-Jos{\'e} S{\'a}nchez and Nerea Larra{\~n}aga and Carmen Navarro and Eva Ardanaz and Kay-Tee Khaw and Wareham, {Nicholas J} and Key, {Timothy J} and Allen, {Naomi E} and Antonia Trichopoulou and Pagona Lagiou and Domenico Palli and Sabina Sieri and Rosario Tumino and Salvatore Panico and Hendriek Boshuizen and B{\"u}chner, {Frederike L} and Peeters, {Petra H M} and Signe Borgquist and Martin Almquist and G{\"o}ran Hallmans and Ingegerd Johansson and Gram, {Inger T} and Eiliv Lund and Elisabete Weiderpass and Isabelle Romieu and Elio Riboli",

year = "2012",

month = dec,

day = "20",

doi = "10.1200/JCO.2011.41.0183",

language = "English",

volume = "30",

pages = "4550--4557",

journal = "Journal of Clinical Oncology",

publisher = "Lippincott Williams and Wilkins",

number = "36",

}

Agudo, A, Bonet, C, Travier, N, González, CA, Vineis, P, Bueno-de-Mesquita, HB, Trichopoulos, D, Boffetta, P, Clavel-Chapelon, F, Boutron-Ruault, M-C, Kaaks, R, Lukanova, A, Schütze, M, Boeing, H, Tjonneland, A, Halkjaer, J, Overvad, K, Dahm, CC, Quirós, JR, Sánchez, M-J, Larrañaga, N, Navarro, C, Ardanaz, E, Khaw, K-T, Wareham, NJ, Key, TJ, Allen, NE, Trichopoulou, A, Lagiou, P, Palli, D, Sieri, S, Tumino, R, Panico, S, Boshuizen, H, Büchner, FL, Peeters, PHM, Borgquist, S, Almquist, M, Hallmans, G, Johansson, I, Gram, IT, Lund, E, Weiderpass, E, Romieu, I & Riboli, E 2012, 'Impact of cigarette smoking on cancer risk in the European prospective investigation into cancer and nutrition study', Journal of Clinical Oncology, vol. 30, no. 36, pp. 4550-4557. https://doi.org/10.1200/JCO.2011.41.0183

TY - JOUR

T1 - Impact of cigarette smoking on cancer risk in the European prospective investigation into cancer and nutrition study

AU - Agudo, Antonio

AU - Bonet, Catalina

AU - Travier, Noémie

AU - González, Carlos A

AU - Vineis, Paolo

AU - Bueno-de-Mesquita, H Bas

AU - Trichopoulos, Dimitrios

AU - Boffetta, Paolo

AU - Clavel-Chapelon, Françoise

AU - Boutron-Ruault, Marie-Christine

AU - Kaaks, Rudolf

AU - Lukanova, Annekatrin

AU - Schütze, Madlen

AU - Boeing, Heiner

AU - Tjonneland, Anne

AU - Halkjaer, Jytte

AU - Overvad, Kim

AU - Dahm, Christina C

AU - Quirós, J Ramon

AU - Sánchez, María-José

AU - Larrañaga, Nerea

AU - Navarro, Carmen

AU - Ardanaz, Eva

AU - Khaw, Kay-Tee

AU - Wareham, Nicholas J

AU - Key, Timothy J

AU - Allen, Naomi E

AU - Trichopoulou, Antonia

AU - Lagiou, Pagona

AU - Palli, Domenico

AU - Sieri, Sabina

AU - Tumino, Rosario

AU - Panico, Salvatore

AU - Boshuizen, Hendriek

AU - Büchner, Frederike L

AU - Peeters, Petra H M

AU - Borgquist, Signe

AU - Almquist, Martin

AU - Hallmans, Göran

AU - Johansson, Ingegerd

AU - Gram, Inger T

AU - Lund, Eiliv

AU - Weiderpass, Elisabete

AU - Romieu, Isabelle

AU - Riboli, Elio

PY - 2012/12/20

Y1 - 2012/12/20

N2 - Purpose: Our aim was to assess the impact of cigarette smoking on the risk of the tumors classified by the International Agency for Research on Cancer as causally associated with smoking, referred to as tobacco-related cancers (TRC).Methods: The study population included 441,211 participants (133,018 men and 308,193 women) from the European Prospective Investigation Into Cancer and Nutrition. We investigated 14,563 participants who developed a TRC during an average follow-up of 11 years. The impact of smoking cigarettes on cancer risk was assessed by the population attributable fraction (AFp), calculated using the adjusted hazard ratios and 95% CI for current and former smokers, plus either the prevalence of smoking among cancer cases or estimates from surveys in representative samples of the population in each country.Results: The proportion of all TRC attributable to cigarette smoking was 34.9% (95% CI, 32.5 to 37.4) using the smoking prevalence among cases and 36.2% (95% CI, 33.7 to 38.6) using the smoking prevalence from the population. The AFp were above 80% for cancers of the lung and larynx, between 20% and 50% for most respiratory and digestive cancers and tumors from the lower urinary tract, and below 20% for the remaining TRC.Conclusion: Using data on cancer incidence for 2008 and our AFp estimates, about 270,000 new cancer diagnoses per year can be considered attributable to cigarette smoking in the eight European countries with available data for both men and women (Italy, Spain, United Kingdom, the Netherlands, Greece, Germany, Sweden, Denmark).

AB - Purpose: Our aim was to assess the impact of cigarette smoking on the risk of the tumors classified by the International Agency for Research on Cancer as causally associated with smoking, referred to as tobacco-related cancers (TRC).Methods: The study population included 441,211 participants (133,018 men and 308,193 women) from the European Prospective Investigation Into Cancer and Nutrition. We investigated 14,563 participants who developed a TRC during an average follow-up of 11 years. The impact of smoking cigarettes on cancer risk was assessed by the population attributable fraction (AFp), calculated using the adjusted hazard ratios and 95% CI for current and former smokers, plus either the prevalence of smoking among cancer cases or estimates from surveys in representative samples of the population in each country.Results: The proportion of all TRC attributable to cigarette smoking was 34.9% (95% CI, 32.5 to 37.4) using the smoking prevalence among cases and 36.2% (95% CI, 33.7 to 38.6) using the smoking prevalence from the population. The AFp were above 80% for cancers of the lung and larynx, between 20% and 50% for most respiratory and digestive cancers and tumors from the lower urinary tract, and below 20% for the remaining TRC.Conclusion: Using data on cancer incidence for 2008 and our AFp estimates, about 270,000 new cancer diagnoses per year can be considered attributable to cigarette smoking in the eight European countries with available data for both men and women (Italy, Spain, United Kingdom, the Netherlands, Greece, Germany, Sweden, Denmark).

KW - young adult

KW - smoking

KW - neoplasms

KW - questionnaires

KW - prospective studies

KW - risk factors

KW - humans

KW - adult

KW - europe

KW - adolescent

KW - male

KW - female

UR - http://jco.ascopubs.org/

U2 - 10.1200/JCO.2011.41.0183

DO - 10.1200/JCO.2011.41.0183

M3 - Article

C2 - 23169508

VL - 30

SP - 4550

EP - 4557

JO - Journal of Clinical Oncology

JF - Journal of Clinical Oncology

IS - 36

ER -

Impact of cigarette smoking on cancer risk in the European prospective investigation into cancer and nutrition study

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this