Impact of cigarette smoking on cancer risk in the European prospective investigation into cancer and nutrition study

Antonio Agudo, Catalina Bonet, Noémie Travier, Carlos A González, Paolo Vineis, H Bas Bueno-de-Mesquita, Dimitrios Trichopoulos, Paolo Boffetta, Françoise Clavel-Chapelon, Marie-Christine Boutron-Ruault, Rudolf Kaaks, Annekatrin Lukanova, Madlen Schütze, Heiner Boeing, Anne Tjonneland, Jytte Halkjaer, Kim Overvad, Christina C Dahm, J Ramon Quirós, María-José Sánchez & 25 others Nerea Larrañaga, Carmen Navarro, Eva Ardanaz, Kay-Tee Khaw, Nicholas J Wareham, Timothy J Key, Naomi E Allen, Antonia Trichopoulou, Pagona Lagiou, Domenico Palli, Sabina Sieri, Rosario Tumino, Salvatore Panico, Hendriek Boshuizen, Frederike L Büchner, Petra H M Peeters, Signe Borgquist, Martin Almquist, Göran Hallmans, Ingegerd Johansson, Inger T Gram, Eiliv Lund, Elisabete Weiderpass, Isabelle Romieu, Elio Riboli

Research output: Contribution to journalArticle

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Abstract

Purpose: Our aim was to assess the impact of cigarette smoking on the risk of the tumors classified by the International Agency for Research on Cancer as causally associated with smoking, referred to as tobacco-related cancers (TRC).
Methods: The study population included 441,211 participants (133,018 men and 308,193 women) from the European Prospective Investigation Into Cancer and Nutrition. We investigated 14,563 participants who developed a TRC during an average follow-up of 11 years. The impact of smoking cigarettes on cancer risk was assessed by the population attributable fraction (AFp), calculated using the adjusted hazard ratios and 95% CI for current and former smokers, plus either the prevalence of smoking among cancer cases or estimates from surveys in representative samples of the population in each country.
Results: The proportion of all TRC attributable to cigarette smoking was 34.9% (95% CI, 32.5 to 37.4) using the smoking prevalence among cases and 36.2% (95% CI, 33.7 to 38.6) using the smoking prevalence from the population. The AFp were above 80% for cancers of the lung and larynx, between 20% and 50% for most respiratory and digestive cancers and tumors from the lower urinary tract, and below 20% for the remaining TRC.
Conclusion: Using data on cancer incidence for 2008 and our AFp estimates, about 270,000 new cancer diagnoses per year can be considered attributable to cigarette smoking in the eight European countries with available data for both men and women (Italy, Spain, United Kingdom, the Netherlands, Greece, Germany, Sweden, Denmark).
LanguageEnglish
Pages4550-4557
Number of pages8
JournalJournal of Clinical Oncology
Volume30
Issue number36
Early online date19 Nov 2012
DOIs
Publication statusPublished - 20 Dec 2012

Fingerprint

Smoking
Neoplasms
Tobacco
Population
International Agencies
Laryngeal Neoplasms
Greece
Denmark
Urinary Tract
Sweden
Netherlands
Spain
Italy
Germany
Lung Neoplasms
Incidence

Keywords

  • young adult
  • smoking
  • neoplasms
  • questionnaires
  • prospective studies
  • risk factors
  • humans
  • adult
  • europe
  • adolescent
  • male
  • female

Cite this

Agudo, A., Bonet, C., Travier, N., González, C. A., Vineis, P., Bueno-de-Mesquita, H. B., ... Riboli, E. (2012). Impact of cigarette smoking on cancer risk in the European prospective investigation into cancer and nutrition study. Journal of Clinical Oncology, 30(36), 4550-4557. https://doi.org/10.1200/JCO.2011.41.0183
Agudo, Antonio ; Bonet, Catalina ; Travier, Noémie ; González, Carlos A ; Vineis, Paolo ; Bueno-de-Mesquita, H Bas ; Trichopoulos, Dimitrios ; Boffetta, Paolo ; Clavel-Chapelon, Françoise ; Boutron-Ruault, Marie-Christine ; Kaaks, Rudolf ; Lukanova, Annekatrin ; Schütze, Madlen ; Boeing, Heiner ; Tjonneland, Anne ; Halkjaer, Jytte ; Overvad, Kim ; Dahm, Christina C ; Quirós, J Ramon ; Sánchez, María-José ; Larrañaga, Nerea ; Navarro, Carmen ; Ardanaz, Eva ; Khaw, Kay-Tee ; Wareham, Nicholas J ; Key, Timothy J ; Allen, Naomi E ; Trichopoulou, Antonia ; Lagiou, Pagona ; Palli, Domenico ; Sieri, Sabina ; Tumino, Rosario ; Panico, Salvatore ; Boshuizen, Hendriek ; Büchner, Frederike L ; Peeters, Petra H M ; Borgquist, Signe ; Almquist, Martin ; Hallmans, Göran ; Johansson, Ingegerd ; Gram, Inger T ; Lund, Eiliv ; Weiderpass, Elisabete ; Romieu, Isabelle ; Riboli, Elio. / Impact of cigarette smoking on cancer risk in the European prospective investigation into cancer and nutrition study. In: Journal of Clinical Oncology. 2012 ; Vol. 30, No. 36. pp. 4550-4557.
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abstract = "Purpose: Our aim was to assess the impact of cigarette smoking on the risk of the tumors classified by the International Agency for Research on Cancer as causally associated with smoking, referred to as tobacco-related cancers (TRC).Methods: The study population included 441,211 participants (133,018 men and 308,193 women) from the European Prospective Investigation Into Cancer and Nutrition. We investigated 14,563 participants who developed a TRC during an average follow-up of 11 years. The impact of smoking cigarettes on cancer risk was assessed by the population attributable fraction (AFp), calculated using the adjusted hazard ratios and 95{\%} CI for current and former smokers, plus either the prevalence of smoking among cancer cases or estimates from surveys in representative samples of the population in each country.Results: The proportion of all TRC attributable to cigarette smoking was 34.9{\%} (95{\%} CI, 32.5 to 37.4) using the smoking prevalence among cases and 36.2{\%} (95{\%} CI, 33.7 to 38.6) using the smoking prevalence from the population. The AFp were above 80{\%} for cancers of the lung and larynx, between 20{\%} and 50{\%} for most respiratory and digestive cancers and tumors from the lower urinary tract, and below 20{\%} for the remaining TRC.Conclusion: Using data on cancer incidence for 2008 and our AFp estimates, about 270,000 new cancer diagnoses per year can be considered attributable to cigarette smoking in the eight European countries with available data for both men and women (Italy, Spain, United Kingdom, the Netherlands, Greece, Germany, Sweden, Denmark).",
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Agudo, A, Bonet, C, Travier, N, González, CA, Vineis, P, Bueno-de-Mesquita, HB, Trichopoulos, D, Boffetta, P, Clavel-Chapelon, F, Boutron-Ruault, M-C, Kaaks, R, Lukanova, A, Schütze, M, Boeing, H, Tjonneland, A, Halkjaer, J, Overvad, K, Dahm, CC, Quirós, JR, Sánchez, M-J, Larrañaga, N, Navarro, C, Ardanaz, E, Khaw, K-T, Wareham, NJ, Key, TJ, Allen, NE, Trichopoulou, A, Lagiou, P, Palli, D, Sieri, S, Tumino, R, Panico, S, Boshuizen, H, Büchner, FL, Peeters, PHM, Borgquist, S, Almquist, M, Hallmans, G, Johansson, I, Gram, IT, Lund, E, Weiderpass, E, Romieu, I & Riboli, E 2012, 'Impact of cigarette smoking on cancer risk in the European prospective investigation into cancer and nutrition study' Journal of Clinical Oncology, vol. 30, no. 36, pp. 4550-4557. https://doi.org/10.1200/JCO.2011.41.0183

Impact of cigarette smoking on cancer risk in the European prospective investigation into cancer and nutrition study. / Agudo, Antonio; Bonet, Catalina; Travier, Noémie; González, Carlos A; Vineis, Paolo; Bueno-de-Mesquita, H Bas; Trichopoulos, Dimitrios; Boffetta, Paolo; Clavel-Chapelon, Françoise; Boutron-Ruault, Marie-Christine; Kaaks, Rudolf; Lukanova, Annekatrin; Schütze, Madlen; Boeing, Heiner; Tjonneland, Anne; Halkjaer, Jytte; Overvad, Kim; Dahm, Christina C; Quirós, J Ramon; Sánchez, María-José; Larrañaga, Nerea; Navarro, Carmen; Ardanaz, Eva; Khaw, Kay-Tee; Wareham, Nicholas J; Key, Timothy J; Allen, Naomi E; Trichopoulou, Antonia; Lagiou, Pagona; Palli, Domenico; Sieri, Sabina; Tumino, Rosario; Panico, Salvatore; Boshuizen, Hendriek; Büchner, Frederike L; Peeters, Petra H M; Borgquist, Signe; Almquist, Martin; Hallmans, Göran; Johansson, Ingegerd; Gram, Inger T; Lund, Eiliv; Weiderpass, Elisabete; Romieu, Isabelle; Riboli, Elio.

In: Journal of Clinical Oncology, Vol. 30, No. 36, 20.12.2012, p. 4550-4557.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Impact of cigarette smoking on cancer risk in the European prospective investigation into cancer and nutrition study

AU - Agudo, Antonio

AU - Bonet, Catalina

AU - Travier, Noémie

AU - González, Carlos A

AU - Vineis, Paolo

AU - Bueno-de-Mesquita, H Bas

AU - Trichopoulos, Dimitrios

AU - Boffetta, Paolo

AU - Clavel-Chapelon, Françoise

AU - Boutron-Ruault, Marie-Christine

AU - Kaaks, Rudolf

AU - Lukanova, Annekatrin

AU - Schütze, Madlen

AU - Boeing, Heiner

AU - Tjonneland, Anne

AU - Halkjaer, Jytte

AU - Overvad, Kim

AU - Dahm, Christina C

AU - Quirós, J Ramon

AU - Sánchez, María-José

AU - Larrañaga, Nerea

AU - Navarro, Carmen

AU - Ardanaz, Eva

AU - Khaw, Kay-Tee

AU - Wareham, Nicholas J

AU - Key, Timothy J

AU - Allen, Naomi E

AU - Trichopoulou, Antonia

AU - Lagiou, Pagona

AU - Palli, Domenico

AU - Sieri, Sabina

AU - Tumino, Rosario

AU - Panico, Salvatore

AU - Boshuizen, Hendriek

AU - Büchner, Frederike L

AU - Peeters, Petra H M

AU - Borgquist, Signe

AU - Almquist, Martin

AU - Hallmans, Göran

AU - Johansson, Ingegerd

AU - Gram, Inger T

AU - Lund, Eiliv

AU - Weiderpass, Elisabete

AU - Romieu, Isabelle

AU - Riboli, Elio

PY - 2012/12/20

Y1 - 2012/12/20

N2 - Purpose: Our aim was to assess the impact of cigarette smoking on the risk of the tumors classified by the International Agency for Research on Cancer as causally associated with smoking, referred to as tobacco-related cancers (TRC).Methods: The study population included 441,211 participants (133,018 men and 308,193 women) from the European Prospective Investigation Into Cancer and Nutrition. We investigated 14,563 participants who developed a TRC during an average follow-up of 11 years. The impact of smoking cigarettes on cancer risk was assessed by the population attributable fraction (AFp), calculated using the adjusted hazard ratios and 95% CI for current and former smokers, plus either the prevalence of smoking among cancer cases or estimates from surveys in representative samples of the population in each country.Results: The proportion of all TRC attributable to cigarette smoking was 34.9% (95% CI, 32.5 to 37.4) using the smoking prevalence among cases and 36.2% (95% CI, 33.7 to 38.6) using the smoking prevalence from the population. The AFp were above 80% for cancers of the lung and larynx, between 20% and 50% for most respiratory and digestive cancers and tumors from the lower urinary tract, and below 20% for the remaining TRC.Conclusion: Using data on cancer incidence for 2008 and our AFp estimates, about 270,000 new cancer diagnoses per year can be considered attributable to cigarette smoking in the eight European countries with available data for both men and women (Italy, Spain, United Kingdom, the Netherlands, Greece, Germany, Sweden, Denmark).

AB - Purpose: Our aim was to assess the impact of cigarette smoking on the risk of the tumors classified by the International Agency for Research on Cancer as causally associated with smoking, referred to as tobacco-related cancers (TRC).Methods: The study population included 441,211 participants (133,018 men and 308,193 women) from the European Prospective Investigation Into Cancer and Nutrition. We investigated 14,563 participants who developed a TRC during an average follow-up of 11 years. The impact of smoking cigarettes on cancer risk was assessed by the population attributable fraction (AFp), calculated using the adjusted hazard ratios and 95% CI for current and former smokers, plus either the prevalence of smoking among cancer cases or estimates from surveys in representative samples of the population in each country.Results: The proportion of all TRC attributable to cigarette smoking was 34.9% (95% CI, 32.5 to 37.4) using the smoking prevalence among cases and 36.2% (95% CI, 33.7 to 38.6) using the smoking prevalence from the population. The AFp were above 80% for cancers of the lung and larynx, between 20% and 50% for most respiratory and digestive cancers and tumors from the lower urinary tract, and below 20% for the remaining TRC.Conclusion: Using data on cancer incidence for 2008 and our AFp estimates, about 270,000 new cancer diagnoses per year can be considered attributable to cigarette smoking in the eight European countries with available data for both men and women (Italy, Spain, United Kingdom, the Netherlands, Greece, Germany, Sweden, Denmark).

KW - young adult

KW - smoking

KW - neoplasms

KW - questionnaires

KW - prospective studies

KW - risk factors

KW - humans

KW - adult

KW - europe

KW - adolescent

KW - male

KW - female

UR - http://jco.ascopubs.org/

U2 - 10.1200/JCO.2011.41.0183

DO - 10.1200/JCO.2011.41.0183

M3 - Article

VL - 30

SP - 4550

EP - 4557

JO - Journal of Clinical Oncology

T2 - Journal of Clinical Oncology

JF - Journal of Clinical Oncology

SN - 0732-183X

IS - 36

ER -