Immunostimulatory lipid nanoparticles from herbal medicine

Tal H. Hasson, Anna Takaoka, Roberto De La Rica, Hiroshi Matsui, Gabriela Smeureanu, Charles Michael Drain, Akira Kawamura

Research output: Contribution to journalLetter

Abstract

Reproducibility is an important issue in biological characterization of drug candidates and natural products. It is not uncommon to encounter cases in which supposedly the same sample exhibits very different biological activities. During our characterization of macrophage-stimulatory lipids from herbal medicine, it was found that the potency of these lipids could vary substantially from experiment to experiment. Further analysis of this reproducibility issue led to the discovery of solvent-dependent nanoparticle formation by these lipids. While larger nanoparticles (approximately 100 nm) of these lipids showed modest macrophage-stimulatory activity, smaller nanoparticles (<10 nm) of the same lipids exhibited substantially higher potency. Thus, the study revealed an unexpected link between nanoparticle formation and macrophage-stimulatory activity of plant lipids. Although nanoparticles have been extensively studied in the context of vehicles for drug delivery, our finding indicates that drugs themselves can form nanoassemblies, and their biological properties may be altered by the way they assemble.
Original languageEnglish
Pages (from-to)493–497
Number of pages5
JournalChemical Biology and Drug Design
Volume83
Issue number4
Early online date5 Feb 2014
DOIs
Publication statusPublished - Apr 2014

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Herbal Medicine
Nanoparticles
Lipids
Macrophages
Pharmaceutical Preparations
Bioactivity
Biological Products
Drug delivery
Experiments

Keywords

  • atomic force microscopy
  • dynamic light scattering
  • Juzen-taiho-to
  • macrophages
  • nanoparticles
  • β-sitosteryl β-d-glucoside

Cite this

Hasson, T. H., Takaoka, A., De La Rica, R., Matsui, H., Smeureanu, G., Drain, C. M., & Kawamura, A. (2014). Immunostimulatory lipid nanoparticles from herbal medicine. Chemical Biology and Drug Design, 83(4), 493–497. https://doi.org/10.1111/cbdd.12250
Hasson, Tal H. ; Takaoka, Anna ; De La Rica, Roberto ; Matsui, Hiroshi ; Smeureanu, Gabriela ; Drain, Charles Michael ; Kawamura, Akira. / Immunostimulatory lipid nanoparticles from herbal medicine. In: Chemical Biology and Drug Design. 2014 ; Vol. 83, No. 4. pp. 493–497.
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Hasson, TH, Takaoka, A, De La Rica, R, Matsui, H, Smeureanu, G, Drain, CM & Kawamura, A 2014, 'Immunostimulatory lipid nanoparticles from herbal medicine', Chemical Biology and Drug Design, vol. 83, no. 4, pp. 493–497. https://doi.org/10.1111/cbdd.12250

Immunostimulatory lipid nanoparticles from herbal medicine. / Hasson, Tal H.; Takaoka, Anna; De La Rica, Roberto; Matsui, Hiroshi; Smeureanu, Gabriela; Drain, Charles Michael; Kawamura, Akira.

In: Chemical Biology and Drug Design, Vol. 83, No. 4, 04.2014, p. 493–497.

Research output: Contribution to journalLetter

TY - JOUR

T1 - Immunostimulatory lipid nanoparticles from herbal medicine

AU - Hasson, Tal H.

AU - Takaoka, Anna

AU - De La Rica, Roberto

AU - Matsui, Hiroshi

AU - Smeureanu, Gabriela

AU - Drain, Charles Michael

AU - Kawamura, Akira

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AB - Reproducibility is an important issue in biological characterization of drug candidates and natural products. It is not uncommon to encounter cases in which supposedly the same sample exhibits very different biological activities. During our characterization of macrophage-stimulatory lipids from herbal medicine, it was found that the potency of these lipids could vary substantially from experiment to experiment. Further analysis of this reproducibility issue led to the discovery of solvent-dependent nanoparticle formation by these lipids. While larger nanoparticles (approximately 100 nm) of these lipids showed modest macrophage-stimulatory activity, smaller nanoparticles (<10 nm) of the same lipids exhibited substantially higher potency. Thus, the study revealed an unexpected link between nanoparticle formation and macrophage-stimulatory activity of plant lipids. Although nanoparticles have been extensively studied in the context of vehicles for drug delivery, our finding indicates that drugs themselves can form nanoassemblies, and their biological properties may be altered by the way they assemble.

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Hasson TH, Takaoka A, De La Rica R, Matsui H, Smeureanu G, Drain CM et al. Immunostimulatory lipid nanoparticles from herbal medicine. Chemical Biology and Drug Design. 2014 Apr;83(4):493–497. https://doi.org/10.1111/cbdd.12250