ES-62 is a protein that is actively secreted by filarial nematodes during parasitism of the vertebrate host. The molecule is able to directly interact with a number of cells of the immune system including B-lymphocytes, dendritic cells, macrophages and mast cells. Interaction appears to be dependent on complexing with TLR4 and results in modulation of the activity of a number of signal transduction molecules including MAP kinases, PI-3 kinase and NF-kappaB. Immunomodulatory activity of ES-62 appears to be largely due to the presence of phosphorylcholine (PC) moieties covalently attached to N-type glycans. The net effect of ES-62's interaction with the immune system is the generation of an anti-inflammatory immunological phenotype. As a consequence of this, ES-62 demonstrates striking drug-like activity in models of disease associated with aberrant inflammation, in particular those associated with autoimmunity and allergy.
|Title of host publication||Pathogen-Derived Immunomodulatory Molecules|
|Number of pages||6|
|Publication status||Published - 2009|
|Name||Advances in Experimental Medicine and Biology|
- immunomodulatory activity
- therapeutic potential
Harnett, W., Harnett, M. M., & Fallon, P. (Ed.) (2009). Immunomodulatory activity and therapeutic potential of the filarial nematode secreted product, ES-62. In Pathogen-Derived Immunomodulatory Molecules (Vol. 666, pp. 88-94). (Advances in Experimental Medicine and Biology).