@inbook{a3a87037cc6647108228c92044a9ae38,
title = "Immunomodulatory activity and therapeutic potential of the filarial nematode secreted product, ES-62",
abstract = "ES-62 is a protein that is actively secreted by filarial nematodes during parasitism of the vertebrate host. The molecule is able to directly interact with a number of cells of the immune system including B-lymphocytes, dendritic cells, macrophages and mast cells. Interaction appears to be dependent on complexing with TLR4 and results in modulation of the activity of a number of signal transduction molecules including MAP kinases, PI-3 kinase and NF-kappaB. Immunomodulatory activity of ES-62 appears to be largely due to the presence of phosphorylcholine (PC) moieties covalently attached to N-type glycans. The net effect of ES-62's interaction with the immune system is the generation of an anti-inflammatory immunological phenotype. As a consequence of this, ES-62 demonstrates striking drug-like activity in models of disease associated with aberrant inflammation, in particular those associated with autoimmunity and allergy.",
keywords = "immunomodulatory activity, therapeutic potential, ES-62",
author = "W. Harnett and M.M. Harnett and Padraic Fallon",
year = "2009",
language = "English",
isbn = "978-1-4419-1600-6",
volume = "666",
series = "Advances in Experimental Medicine and Biology",
publisher = "Landes Bioscience",
pages = "88--94",
booktitle = "Pathogen-Derived Immunomodulatory Molecules",
}