Immunomic discovery of adjuvants and candidate subunit vaccines

Darren R. Flower, Yvonne Perrie

Research output: Book/ReportBook

2 Citations (Scopus)

Abstract

This volume will address an important emergent area within the field of immunomics: the discovery of antigens and adjuvants within the context of reverse vaccinology. Conventional approaches to vaccine design and development requires pathogens to be cultivated in the laboratory and the immunogenic molecules within them to be identifiable. Conventional vaccinology is no longer universally successful, particularly for recalcitrant pathogens. By using genomic information we can study vaccine development in silico: 'reverse vaccinology', can identify candidate subunits vaccines by identifying antigenic proteins and by using equally rational approaches to identify novel immune response-enhancing adjuvants.

Original languageEnglish
Place of PublicationNew York
Number of pages314
Volume5
ISBN (Electronic)9781461450702
DOIs
Publication statusPublished - 1 Jan 2013

Publication series

NameImmunomics Reviews
PublisherSpringer
Volume5

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Keywords

  • vaccines
  • adjuvants

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