Abstract
A series of studies over 20 years mapped resistance to toxoplasmic encephalitis in mice to major histocompatibility complex class I (MHC I) and ultimately, more precisely the Ld region This is consistent with contemporary functional studies that demonstrated a protective role for CD8(+) T cells Recent studies have demonstrated that the Ld gene product presents a number of immunodominant Toxoplasma gondii-derived peptides in the murine models, providing a paradigm for vaccine design The almost complete sequencing of the genomes of the predominant strains of T gondii in conjunction with the development of predictive binding algorithms for MHC I peptides in humans now offers a new opportunity for vaccine development against this medically important pathogen
| Language | English |
|---|---|
| Pages | 550-555 |
| Number of pages | 6 |
| Journal | Trends in Parasitology |
| Volume | 26 |
| Issue number | 11 |
| Early online date | 30 Jun 2010 |
| DOIs | |
| Publication status | Published - Nov 2010 |
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Keywords
- CD8+ t-cells
- TNF-ALPHA
- peroral infection
- immune-response
- small intestine
- IFN-GAMMA
- congenital toxoplasmosis
- ocular toxoplasmosis
- genetic-regulation
- early survival
Cite this
}
Immunogenetics of toxoplasma gondii informs vaccine design. / Henriquez, Fiona L.; Woods, Stuart; Cong, Hua; McLeod, Rima; Roberts, Craig.
In: Trends in Parasitology, Vol. 26, No. 11, 11.2010, p. 550-555.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Immunogenetics of toxoplasma gondii informs vaccine design
AU - Henriquez, Fiona L.
AU - Woods, Stuart
AU - Cong, Hua
AU - McLeod, Rima
AU - Roberts, Craig
PY - 2010/11
Y1 - 2010/11
N2 - A series of studies over 20 years mapped resistance to toxoplasmic encephalitis in mice to major histocompatibility complex class I (MHC I) and ultimately, more precisely the Ld region This is consistent with contemporary functional studies that demonstrated a protective role for CD8(+) T cells Recent studies have demonstrated that the Ld gene product presents a number of immunodominant Toxoplasma gondii-derived peptides in the murine models, providing a paradigm for vaccine design The almost complete sequencing of the genomes of the predominant strains of T gondii in conjunction with the development of predictive binding algorithms for MHC I peptides in humans now offers a new opportunity for vaccine development against this medically important pathogen
AB - A series of studies over 20 years mapped resistance to toxoplasmic encephalitis in mice to major histocompatibility complex class I (MHC I) and ultimately, more precisely the Ld region This is consistent with contemporary functional studies that demonstrated a protective role for CD8(+) T cells Recent studies have demonstrated that the Ld gene product presents a number of immunodominant Toxoplasma gondii-derived peptides in the murine models, providing a paradigm for vaccine design The almost complete sequencing of the genomes of the predominant strains of T gondii in conjunction with the development of predictive binding algorithms for MHC I peptides in humans now offers a new opportunity for vaccine development against this medically important pathogen
KW - CD8+ t-cells
KW - TNF-ALPHA
KW - peroral infection
KW - immune-response
KW - small intestine
KW - IFN-GAMMA
KW - congenital toxoplasmosis
KW - ocular toxoplasmosis
KW - genetic-regulation
KW - early survival
UR - http://www.scopus.com/inward/record.url?scp=77957926717&partnerID=8YFLogxK
U2 - 10.1016/j.pt.2010.06.004
DO - 10.1016/j.pt.2010.06.004
M3 - Review article
VL - 26
SP - 550
EP - 555
JO - Trends in Parasitology
T2 - Trends in Parasitology
JF - Trends in Parasitology
SN - 1471-4922
IS - 11
ER -