Abstract
A series of studies over 20 years mapped resistance to toxoplasmic encephalitis in mice to major histocompatibility complex class I (MHC I) and ultimately, more precisely the Ld region This is consistent with contemporary functional studies that demonstrated a protective role for CD8(+) T cells Recent studies have demonstrated that the Ld gene product presents a number of immunodominant Toxoplasma gondii-derived peptides in the murine models, providing a paradigm for vaccine design The almost complete sequencing of the genomes of the predominant strains of T gondii in conjunction with the development of predictive binding algorithms for MHC I peptides in humans now offers a new opportunity for vaccine development against this medically important pathogen
Original language | English |
---|---|
Pages (from-to) | 550-555 |
Number of pages | 6 |
Journal | Trends in Parasitology |
Volume | 26 |
Issue number | 11 |
Early online date | 30 Jun 2010 |
DOIs | |
Publication status | Published - Nov 2010 |
Keywords
- CD8+ t-cells
- TNF-ALPHA
- peroral infection
- immune-response
- small intestine
- IFN-GAMMA
- congenital toxoplasmosis
- ocular toxoplasmosis
- genetic-regulation
- early survival