Immunogenetics of toxoplasma gondii informs vaccine design

Fiona L. Henriquez, Stuart Woods, Hua Cong, Rima McLeod, Craig Roberts

Research output: Contribution to journalReview article

33 Citations (Scopus)

Abstract

A series of studies over 20 years mapped resistance to toxoplasmic encephalitis in mice to major histocompatibility complex class I (MHC I) and ultimately, more precisely the Ld region This is consistent with contemporary functional studies that demonstrated a protective role for CD8(+) T cells Recent studies have demonstrated that the Ld gene product presents a number of immunodominant Toxoplasma gondii-derived peptides in the murine models, providing a paradigm for vaccine design The almost complete sequencing of the genomes of the predominant strains of T gondii in conjunction with the development of predictive binding algorithms for MHC I peptides in humans now offers a new opportunity for vaccine development against this medically important pathogen

LanguageEnglish
Pages550-555
Number of pages6
JournalTrends in Parasitology
Volume26
Issue number11
Early online date30 Jun 2010
DOIs
Publication statusPublished - Nov 2010

Fingerprint

Immunogenetics
Toxoplasma
Major Histocompatibility Complex
Vaccines
Genes
Peptides
T-cells
Pathogens
Encephalitis
Genome
T-Lymphocytes

Keywords

  • CD8+ t-cells
  • TNF-ALPHA
  • peroral infection
  • immune-response
  • small intestine
  • IFN-GAMMA
  • congenital toxoplasmosis
  • ocular toxoplasmosis
  • genetic-regulation
  • early survival

Cite this

Henriquez, Fiona L. ; Woods, Stuart ; Cong, Hua ; McLeod, Rima ; Roberts, Craig. / Immunogenetics of toxoplasma gondii informs vaccine design. In: Trends in Parasitology. 2010 ; Vol. 26, No. 11. pp. 550-555.
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Immunogenetics of toxoplasma gondii informs vaccine design. / Henriquez, Fiona L.; Woods, Stuart; Cong, Hua; McLeod, Rima; Roberts, Craig.

In: Trends in Parasitology, Vol. 26, No. 11, 11.2010, p. 550-555.

Research output: Contribution to journalReview article

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