Immunogenetics of toxoplasma gondii informs vaccine design

Fiona L. Henriquez, Stuart Woods, Hua Cong, Rima McLeod, Craig Roberts

Research output: Contribution to journalReview article

33 Citations (Scopus)

Abstract

A series of studies over 20 years mapped resistance to toxoplasmic encephalitis in mice to major histocompatibility complex class I (MHC I) and ultimately, more precisely the Ld region This is consistent with contemporary functional studies that demonstrated a protective role for CD8(+) T cells Recent studies have demonstrated that the Ld gene product presents a number of immunodominant Toxoplasma gondii-derived peptides in the murine models, providing a paradigm for vaccine design The almost complete sequencing of the genomes of the predominant strains of T gondii in conjunction with the development of predictive binding algorithms for MHC I peptides in humans now offers a new opportunity for vaccine development against this medically important pathogen

Original languageEnglish
Pages (from-to)550-555
Number of pages6
JournalTrends in Parasitology
Volume26
Issue number11
Early online date30 Jun 2010
DOIs
Publication statusPublished - Nov 2010

    Fingerprint

Keywords

  • CD8+ t-cells
  • TNF-ALPHA
  • peroral infection
  • immune-response
  • small intestine
  • IFN-GAMMA
  • congenital toxoplasmosis
  • ocular toxoplasmosis
  • genetic-regulation
  • early survival

Cite this