Immunization with LHRH for the treatment of hormone-dependent tumours

V. A. Ferro, W. A. Horton, W. H. Stimson

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

1 Citation (Scopus)

Abstract

In this paper, hormone-dependent mammary tumours were induced in female Sprague-Dawley rats. One group of rats was immunized with an analogue of LHRH conjugated to PPD (LHRH-glycys-PPD) concurrently with tumour induction, while another group was immunized following established tumour development. High levels of antibody were induced in response to the LHRH-glycys. This resulted in a decrease in serum levels of oestrogen, which was demonstrated physiologically by disruption of gonadal function. The results show that tumour development was also hindered and thus the anti-tumour potential of LHRH-glycys is realized.

Original languageEnglish
Title of host publicationInstitution of Chemical Engineers Symposium Series
Place of PublicationRugby, UK
Pages40-42
Number of pages3
Publication statusPublished - 1 Jan 1994
EventProceedings of the 2nd Conference on Industrial Immunology - Brighton, UK
Duration: 4 Jul 19945 Jul 1994

Conference

ConferenceProceedings of the 2nd Conference on Industrial Immunology
CityBrighton, UK
Period4/07/945/07/94

Keywords

  • oncology
  • immunization

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  • Cite this

    Ferro, V. A., Horton, W. A., & Stimson, W. H. (1994). Immunization with LHRH for the treatment of hormone-dependent tumours. In Institution of Chemical Engineers Symposium Series (pp. 40-42).