Abstract
In this paper, hormone-dependent mammary tumours were induced in female Sprague-Dawley rats. One group of rats was immunized with an analogue of LHRH conjugated to PPD (LHRH-glycys-PPD) concurrently with tumour induction, while another group was immunized following established tumour development. High levels of antibody were induced in response to the LHRH-glycys. This resulted in a decrease in serum levels of oestrogen, which was demonstrated physiologically by disruption of gonadal function. The results show that tumour development was also hindered and thus the anti-tumour potential of LHRH-glycys is realized.
| Original language | English |
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| Title of host publication | Institution of Chemical Engineers Symposium Series |
| Place of Publication | Rugby, UK |
| Pages | 40-42 |
| Number of pages | 3 |
| Publication status | Published - 1 Jan 1994 |
| Event | Proceedings of the 2nd Conference on Industrial Immunology - Brighton, UK Duration: 4 Jul 1994 → 5 Jul 1994 |
Conference
| Conference | Proceedings of the 2nd Conference on Industrial Immunology |
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| City | Brighton, UK |
| Period | 4/07/94 → 5/07/94 |
Keywords
- oncology
- immunization