Immunization with LHRH for the treatment of hormone-dependent tumours

V. A. Ferro, W. A. Horton, W. H. Stimson

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

1 Citation (Scopus)

Abstract

In this paper, hormone-dependent mammary tumours were induced in female Sprague-Dawley rats. One group of rats was immunized with an analogue of LHRH conjugated to PPD (LHRH-glycys-PPD) concurrently with tumour induction, while another group was immunized following established tumour development. High levels of antibody were induced in response to the LHRH-glycys. This resulted in a decrease in serum levels of oestrogen, which was demonstrated physiologically by disruption of gonadal function. The results show that tumour development was also hindered and thus the anti-tumour potential of LHRH-glycys is realized.

LanguageEnglish
Title of host publicationInstitution of Chemical Engineers Symposium Series
Place of PublicationRugby, UK
Pages40-42
Number of pages3
Publication statusPublished - 1 Jan 1994
EventProceedings of the 2nd Conference on Industrial Immunology - Brighton, UK
Duration: 4 Jul 19945 Jul 1994

Conference

ConferenceProceedings of the 2nd Conference on Industrial Immunology
CityBrighton, UK
Period4/07/945/07/94

Fingerprint

Immunization
Hormones
Gonadotropin-Releasing Hormone
Tumors
Tuberculin
Rats
Antibodies
Estrogens

Keywords

  • oncology
  • immunization

Cite this

Ferro, V. A., Horton, W. A., & Stimson, W. H. (1994). Immunization with LHRH for the treatment of hormone-dependent tumours. In Institution of Chemical Engineers Symposium Series (pp. 40-42). Rugby, UK.
Ferro, V. A. ; Horton, W. A. ; Stimson, W. H. / Immunization with LHRH for the treatment of hormone-dependent tumours. Institution of Chemical Engineers Symposium Series. Rugby, UK, 1994. pp. 40-42
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Ferro, VA, Horton, WA & Stimson, WH 1994, Immunization with LHRH for the treatment of hormone-dependent tumours. in Institution of Chemical Engineers Symposium Series. Rugby, UK, pp. 40-42, Proceedings of the 2nd Conference on Industrial Immunology, Brighton, UK, 4/07/94.

Immunization with LHRH for the treatment of hormone-dependent tumours. / Ferro, V. A.; Horton, W. A.; Stimson, W. H.

Institution of Chemical Engineers Symposium Series. Rugby, UK, 1994. p. 40-42.

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

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Ferro VA, Horton WA, Stimson WH. Immunization with LHRH for the treatment of hormone-dependent tumours. In Institution of Chemical Engineers Symposium Series. Rugby, UK. 1994. p. 40-42