Immune responses to a GnRH-based anti-fertility immunogen, induced by different adjuvants and subsequent effect on vaccine efficacy

V.A. Ferro; R. Costa; K.C. Carter; M.J. Harvey; M.M. Waterston; A. Mullen; C. Matschke; J.F.S. Mann; A. Colston; W.H. Stimson

doi:10.1016/j.vaccine.2003.08.043

Immune responses to a GnRH-based anti-fertility immunogen, induced by different adjuvants and subsequent effect on vaccine efficacy

V.A. Ferro, R. Costa, K.C. Carter, M.J. Harvey, M.M. Waterston, A. Mullen, C. Matschke, J.F.S. Mann, A. Colston, W.H. Stimson

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

A modified GnRH peptide (CHWSYGLRPG-NH2) was conjugated to tetanus toxoid and formulated with different adjuvants (non-ionic surfactant vesicles, aluminium hydroxide, Quil A, PLGA (poly(lactide-co-glycolide)/triacetin), and Quil A/PLGA). A comparison of the anti-fertility efficacy of the formulations was made by examining specific antibody levels, antibody subclasses, endocrine ablation and gonadal atrophy. The production of IgG2b antibody provided the best correlation for castration. PLGA was considered the most effective adjuvant as it produced a consistent anti-fertility response in all the treated animals.

Original language	English
Pages (from-to)	1024-31
Number of pages	8
Journal	Vaccine
Volume	22
Issue number	8
DOIs	https://doi.org/10.1016/j.vaccine.2003.08.043
Publication status	Published - 25 Feb 2004

Keywords

GnRH
anti-fertility
vaccine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.vaccine.2003.08.043

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title = "Immune responses to a GnRH-based anti-fertility immunogen, induced by different adjuvants and subsequent effect on vaccine efficacy",

abstract = "A modified GnRH peptide (CHWSYGLRPG-NH2) was conjugated to tetanus toxoid and formulated with different adjuvants (non-ionic surfactant vesicles, aluminium hydroxide, Quil A, PLGA (poly(lactide-co-glycolide)/triacetin), and Quil A/PLGA). A comparison of the anti-fertility efficacy of the formulations was made by examining specific antibody levels, antibody subclasses, endocrine ablation and gonadal atrophy. The production of IgG2b antibody provided the best correlation for castration. PLGA was considered the most effective adjuvant as it produced a consistent anti-fertility response in all the treated animals.",

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T1 - Immune responses to a GnRH-based anti-fertility immunogen, induced by different adjuvants and subsequent effect on vaccine efficacy

AU - Ferro, V.A.

AU - Costa, R.

AU - Carter, K.C.

AU - Harvey, M.J.

AU - Waterston, M.M.

AU - Mullen, A.

AU - Matschke, C.

AU - Mann, J.F.S.

AU - Colston, A.

AU - Stimson, W.H.

PY - 2004/2/25

Y1 - 2004/2/25

N2 - A modified GnRH peptide (CHWSYGLRPG-NH2) was conjugated to tetanus toxoid and formulated with different adjuvants (non-ionic surfactant vesicles, aluminium hydroxide, Quil A, PLGA (poly(lactide-co-glycolide)/triacetin), and Quil A/PLGA). A comparison of the anti-fertility efficacy of the formulations was made by examining specific antibody levels, antibody subclasses, endocrine ablation and gonadal atrophy. The production of IgG2b antibody provided the best correlation for castration. PLGA was considered the most effective adjuvant as it produced a consistent anti-fertility response in all the treated animals.

AB - A modified GnRH peptide (CHWSYGLRPG-NH2) was conjugated to tetanus toxoid and formulated with different adjuvants (non-ionic surfactant vesicles, aluminium hydroxide, Quil A, PLGA (poly(lactide-co-glycolide)/triacetin), and Quil A/PLGA). A comparison of the anti-fertility efficacy of the formulations was made by examining specific antibody levels, antibody subclasses, endocrine ablation and gonadal atrophy. The production of IgG2b antibody provided the best correlation for castration. PLGA was considered the most effective adjuvant as it produced a consistent anti-fertility response in all the treated animals.

KW - GnRH

KW - anti-fertility

KW - vaccine

U2 - 10.1016/j.vaccine.2003.08.043

DO - 10.1016/j.vaccine.2003.08.043

M3 - Article

SN - 0264-410X

VL - 22

SP - 1024

EP - 1031

JO - Vaccine

JF - Vaccine

IS - 8

ER -

Immune responses to a GnRH-based anti-fertility immunogen, induced by different adjuvants and subsequent effect on vaccine efficacy

Abstract

Keywords

UN SDGs

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