Imidazole catalyzed silica synthesis: Progress toward understanding the role of histidine in (bio)silicification

Siddharth V Patwardhan

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Histidine is an amino acid present in proteins involved in biosilica formation and often found in peptides identified during phage display studies but its role(s) and the extent of its involvement in the silica precipitation process is not fully understood. In this contribution we describe results from an in vitro silicification study conducted using poly-histidine (P-His) and a series of different molecular weight synthetic polymers containing the imidazole functionality (polyvinyl imidazole, PVI) for comparison. We show that the presence of imidazole from PVI or P-His is able to catalyze silicic acid condensation; the effect being greater for P-His. The catalytic mechanism is proposed to involve the dual features of the imidazole group-its ability to form hydrogen bonds with silicic acid and electrostatic attraction toward oligomeric silicic acid species.
LanguageEnglish
Pages1700-1708
Number of pages8
JournalJournal of Materials Research
Volume24
Issue number4
DOIs
Publication statusPublished - 2009

Fingerprint

histidine
imidazoles
Histidine
Silicon Dioxide
Silicic Acid
Silica
silicon dioxide
Acids
Polyvinyls
synthesis
Bacteriophages
acids
Peptides
Amino acids
Condensation
Electrostatics
Hydrogen bonds
Molecular weight
Display devices
Proteins

Keywords

  • imidazole catalyzed silica synthesis
  • histidine
  • (bio)silicification

Cite this

@article{36df6b40d19944df991aedb1362a3637,
title = "Imidazole catalyzed silica synthesis: Progress toward understanding the role of histidine in (bio)silicification",
abstract = "Histidine is an amino acid present in proteins involved in biosilica formation and often found in peptides identified during phage display studies but its role(s) and the extent of its involvement in the silica precipitation process is not fully understood. In this contribution we describe results from an in vitro silicification study conducted using poly-histidine (P-His) and a series of different molecular weight synthetic polymers containing the imidazole functionality (polyvinyl imidazole, PVI) for comparison. We show that the presence of imidazole from PVI or P-His is able to catalyze silicic acid condensation; the effect being greater for P-His. The catalytic mechanism is proposed to involve the dual features of the imidazole group-its ability to form hydrogen bonds with silicic acid and electrostatic attraction toward oligomeric silicic acid species.",
keywords = "imidazole catalyzed silica synthesis, histidine, (bio)silicification",
author = "Patwardhan, {Siddharth V}",
year = "2009",
doi = "10.1557/JMR.2009.0223",
language = "English",
volume = "24",
pages = "1700--1708",
journal = "Journal of Materials Research",
issn = "0884-2914",
number = "4",

}

Imidazole catalyzed silica synthesis: Progress toward understanding the role of histidine in (bio)silicification. / Patwardhan, Siddharth V.

In: Journal of Materials Research, Vol. 24, No. 4, 2009, p. 1700-1708.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Imidazole catalyzed silica synthesis: Progress toward understanding the role of histidine in (bio)silicification

AU - Patwardhan, Siddharth V

PY - 2009

Y1 - 2009

N2 - Histidine is an amino acid present in proteins involved in biosilica formation and often found in peptides identified during phage display studies but its role(s) and the extent of its involvement in the silica precipitation process is not fully understood. In this contribution we describe results from an in vitro silicification study conducted using poly-histidine (P-His) and a series of different molecular weight synthetic polymers containing the imidazole functionality (polyvinyl imidazole, PVI) for comparison. We show that the presence of imidazole from PVI or P-His is able to catalyze silicic acid condensation; the effect being greater for P-His. The catalytic mechanism is proposed to involve the dual features of the imidazole group-its ability to form hydrogen bonds with silicic acid and electrostatic attraction toward oligomeric silicic acid species.

AB - Histidine is an amino acid present in proteins involved in biosilica formation and often found in peptides identified during phage display studies but its role(s) and the extent of its involvement in the silica precipitation process is not fully understood. In this contribution we describe results from an in vitro silicification study conducted using poly-histidine (P-His) and a series of different molecular weight synthetic polymers containing the imidazole functionality (polyvinyl imidazole, PVI) for comparison. We show that the presence of imidazole from PVI or P-His is able to catalyze silicic acid condensation; the effect being greater for P-His. The catalytic mechanism is proposed to involve the dual features of the imidazole group-its ability to form hydrogen bonds with silicic acid and electrostatic attraction toward oligomeric silicic acid species.

KW - imidazole catalyzed silica synthesis

KW - histidine

KW - (bio)silicification

UR - http://dx.doi.org/10.1557/JMR.2009.0223

U2 - 10.1557/JMR.2009.0223

DO - 10.1557/JMR.2009.0223

M3 - Article

VL - 24

SP - 1700

EP - 1708

JO - Journal of Materials Research

T2 - Journal of Materials Research

JF - Journal of Materials Research

SN - 0884-2914

IS - 4

ER -