Imidazole catalyzed silica synthesis: Progress toward understanding the role of histidine in (bio)silicification

Siddharth V Patwardhan

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Histidine is an amino acid present in proteins involved in biosilica formation and often found in peptides identified during phage display studies but its role(s) and the extent of its involvement in the silica precipitation process is not fully understood. In this contribution we describe results from an in vitro silicification study conducted using poly-histidine (P-His) and a series of different molecular weight synthetic polymers containing the imidazole functionality (polyvinyl imidazole, PVI) for comparison. We show that the presence of imidazole from PVI or P-His is able to catalyze silicic acid condensation; the effect being greater for P-His. The catalytic mechanism is proposed to involve the dual features of the imidazole group-its ability to form hydrogen bonds with silicic acid and electrostatic attraction toward oligomeric silicic acid species.
Original languageEnglish
Pages (from-to)1700-1708
Number of pages8
JournalJournal of Materials Research
Volume24
Issue number4
DOIs
Publication statusPublished - 2009

Keywords

  • imidazole catalyzed silica synthesis
  • histidine
  • (bio)silicification

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