Imaging T-cell movement in the brain during experimental cerebral malaria

F. Ortolano, Pasquale Maffia, G. Dever, S. Hutchison, R. Benson, O.R. Millington, M.G. De Simoni, T. Bushell, P. Garside, H.V. Carswell, J.M. Brewer

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

T-cells are known to play a role in the pathology associated with experimental cerebral malaria, although it has not previously been possible to examine their behaviour in brain. Using multiphoton laser scanning microscopy, we have examined the migration and movement of these cells in brain tissue. We believe that this approach will help define host-parasite interactions and examine how intervening in these relationships affects the development of cerebral pathology.
LanguageEnglish
Pages147-150
Number of pages4
JournalParasite Immunology
Volume31
Issue number3
Early online date3 Dec 2008
DOIs
Publication statusPublished - Mar 2009

Fingerprint

Cerebral Malaria
Cell Movement
Pathology
T-Lymphocytes
Host-Parasite Interactions
Brain
Confocal Microscopy

Keywords

  • brain
  • ECM
  • imaging
  • in vivo
  • microscopy
  • plasmodium
  • T lymphocytes
  • pharmacology

Cite this

Ortolano, F., Maffia, P., Dever, G., Hutchison, S., Benson, R., Millington, O. R., ... Brewer, J. M. (2009). Imaging T-cell movement in the brain during experimental cerebral malaria. Parasite Immunology, 31(3), 147-150. https://doi.org/10.1111/j.1365-3024.2008.01090.x
Ortolano, F. ; Maffia, Pasquale ; Dever, G. ; Hutchison, S. ; Benson, R. ; Millington, O.R. ; De Simoni, M.G. ; Bushell, T. ; Garside, P. ; Carswell, H.V. ; Brewer, J.M. / Imaging T-cell movement in the brain during experimental cerebral malaria. In: Parasite Immunology. 2009 ; Vol. 31, No. 3. pp. 147-150.
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Ortolano, F, Maffia, P, Dever, G, Hutchison, S, Benson, R, Millington, OR, De Simoni, MG, Bushell, T, Garside, P, Carswell, HV & Brewer, JM 2009, 'Imaging T-cell movement in the brain during experimental cerebral malaria' Parasite Immunology, vol. 31, no. 3, pp. 147-150. https://doi.org/10.1111/j.1365-3024.2008.01090.x

Imaging T-cell movement in the brain during experimental cerebral malaria. / Ortolano, F.; Maffia, Pasquale; Dever, G.; Hutchison, S.; Benson, R.; Millington, O.R.; De Simoni, M.G.; Bushell, T.; Garside, P.; Carswell, H.V.; Brewer, J.M.

In: Parasite Immunology, Vol. 31, No. 3, 03.2009, p. 147-150.

Research output: Contribution to journalArticle

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T1 - Imaging T-cell movement in the brain during experimental cerebral malaria

AU - Ortolano, F.

AU - Maffia, Pasquale

AU - Dever, G.

AU - Hutchison, S.

AU - Benson, R.

AU - Millington, O.R.

AU - De Simoni, M.G.

AU - Bushell, T.

AU - Garside, P.

AU - Carswell, H.V.

AU - Brewer, J.M.

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AB - T-cells are known to play a role in the pathology associated with experimental cerebral malaria, although it has not previously been possible to examine their behaviour in brain. Using multiphoton laser scanning microscopy, we have examined the migration and movement of these cells in brain tissue. We believe that this approach will help define host-parasite interactions and examine how intervening in these relationships affects the development of cerebral pathology.

KW - brain

KW - ECM

KW - imaging

KW - in vivo

KW - microscopy

KW - plasmodium

KW - T lymphocytes

KW - pharmacology

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DO - 10.1111/j.1365-3024.2008.01090.x

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Ortolano F, Maffia P, Dever G, Hutchison S, Benson R, Millington OR et al. Imaging T-cell movement in the brain during experimental cerebral malaria. Parasite Immunology. 2009 Mar;31(3):147-150. https://doi.org/10.1111/j.1365-3024.2008.01090.x