Imaging T-cell movement in the brain during experimental cerebral malaria

F. Ortolano; Pasquale Maffia; G. Dever; S. Hutchison; R. Benson; O.R. Millington; M.G. De Simoni; T. Bushell; P. Garside; H.V. Carswell; J.M. Brewer

doi:10.1111/j.1365-3024.2008.01090.x

Imaging T-cell movement in the brain during experimental cerebral malaria

F. Ortolano, Pasquale Maffia, G. Dever, S. Hutchison, R. Benson, O.R. Millington, M.G. De Simoni, T. Bushell, P. Garside, H.V. Carswell, J.M. Brewer

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

T-cells are known to play a role in the pathology associated with experimental cerebral malaria, although it has not previously been possible to examine their behaviour in brain. Using multiphoton laser scanning microscopy, we have examined the migration and movement of these cells in brain tissue. We believe that this approach will help define host-parasite interactions and examine how intervening in these relationships affects the development of cerebral pathology.

Original language	English
Pages (from-to)	147-150
Number of pages	4
Journal	Parasite Immunology
Volume	31
Issue number	3
Early online date	3 Dec 2008
DOIs	https://doi.org/10.1111/j.1365-3024.2008.01090.x
Publication status	Published - Mar 2009

Keywords

brain
ECM
imaging
in vivo
microscopy
plasmodium
T lymphocytes
pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1365-3024.2008.01090.x

Cite this

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title = "Imaging T-cell movement in the brain during experimental cerebral malaria",

abstract = "T-cells are known to play a role in the pathology associated with experimental cerebral malaria, although it has not previously been possible to examine their behaviour in brain. Using multiphoton laser scanning microscopy, we have examined the migration and movement of these cells in brain tissue. We believe that this approach will help define host-parasite interactions and examine how intervening in these relationships affects the development of cerebral pathology.",

keywords = "brain, ECM, imaging, in vivo, microscopy, plasmodium, T lymphocytes, pharmacology",

author = "F. Ortolano and Pasquale Maffia and G. Dever and S. Hutchison and R. Benson and O.R. Millington and {De Simoni}, M.G. and T. Bushell and P. Garside and H.V. Carswell and J.M. Brewer",

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doi = "10.1111/j.1365-3024.2008.01090.x",

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TY - JOUR

T1 - Imaging T-cell movement in the brain during experimental cerebral malaria

AU - Ortolano, F.

AU - Maffia, Pasquale

AU - Dever, G.

AU - Hutchison, S.

AU - Benson, R.

AU - Millington, O.R.

AU - De Simoni, M.G.

AU - Bushell, T.

AU - Garside, P.

AU - Carswell, H.V.

AU - Brewer, J.M.

PY - 2009/3

Y1 - 2009/3

N2 - T-cells are known to play a role in the pathology associated with experimental cerebral malaria, although it has not previously been possible to examine their behaviour in brain. Using multiphoton laser scanning microscopy, we have examined the migration and movement of these cells in brain tissue. We believe that this approach will help define host-parasite interactions and examine how intervening in these relationships affects the development of cerebral pathology.

AB - T-cells are known to play a role in the pathology associated with experimental cerebral malaria, although it has not previously been possible to examine their behaviour in brain. Using multiphoton laser scanning microscopy, we have examined the migration and movement of these cells in brain tissue. We believe that this approach will help define host-parasite interactions and examine how intervening in these relationships affects the development of cerebral pathology.

KW - brain

KW - ECM

KW - imaging

KW - in vivo

KW - microscopy

KW - plasmodium

KW - T lymphocytes

KW - pharmacology

U2 - 10.1111/j.1365-3024.2008.01090.x

DO - 10.1111/j.1365-3024.2008.01090.x

M3 - Article

SN - 0141-9838

VL - 31

SP - 147

EP - 150

JO - Parasite Immunology

JF - Parasite Immunology

IS - 3

ER -

Imaging T-cell movement in the brain during experimental cerebral malaria

Abstract

Keywords

UN SDGs

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