Imaging T-cell movement in the brain during experimental cerebral malaria

F. Ortolano, Pasquale Maffia, G. Dever, S. Hutchison, R. Benson, O.R. Millington, M.G. De Simoni, T. Bushell, P. Garside, H.V. Carswell, J.M. Brewer

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Abstract

T-cells are known to play a role in the pathology associated with experimental cerebral malaria, although it has not previously been possible to examine their behaviour in brain. Using multiphoton laser scanning microscopy, we have examined the migration and movement of these cells in brain tissue. We believe that this approach will help define host-parasite interactions and examine how intervening in these relationships affects the development of cerebral pathology.
Original languageEnglish
Pages (from-to)147-150
Number of pages4
JournalParasite Immunology
Volume31
Issue number3
Early online date3 Dec 2008
DOIs
Publication statusPublished - Mar 2009

Keywords

  • brain
  • ECM
  • imaging
  • in vivo
  • microscopy
  • plasmodium
  • T lymphocytes
  • pharmacology

Cite this

Ortolano, F., Maffia, P., Dever, G., Hutchison, S., Benson, R., Millington, O. R., De Simoni, M. G., Bushell, T., Garside, P., Carswell, H. V., & Brewer, J. M. (2009). Imaging T-cell movement in the brain during experimental cerebral malaria. Parasite Immunology, 31(3), 147-150. https://doi.org/10.1111/j.1365-3024.2008.01090.x