Projects per year
Abstract
The detection of subclinical early inflammation in autoimmune diseases is an important but currently technically demanding approach to direct initial diagnosis and subsequent choice of therapy. Recent advances in imaging using NP provides the potential to detect cellular recruitment, vascular activation or leakage at a subclinically stage of disease and may provide predictive 'biomarkers' of future pathogenesis. The NP used are either untargeted and taken up by phagocytic cells, or are linked to a ligand, targeting localisation to the site of inflammation. Techniques, varying from MRI and fluorescence to Raman spectroscopy are being employed. In this short review, we summarise many of the recent developments in the field of NP imaging related to inflammation.
Original language | English |
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Pages (from-to) | 368-372 |
Number of pages | 4 |
Journal | Autoimmunity |
Volume | 42 |
Issue number | 4 |
DOIs | |
Publication status | Published - Apr 2009 |
Keywords
- nanoparticles
- NP
- inflammation
- in vivo imaging
- autoimmune disease
Projects
- 2 Finished
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The Molecular Nose
EPSRC (Engineering and Physical Sciences Research Council)
1/10/07 → 8/04/12
Project: Research
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OPTICAL SPECTROSCOPIES FOR IMMUNO-BIOMEDICAL APPLICATIONS
Graham, D., Alexander, J., Birch, D., Faulds, K., Garside, P. & Smith, W.
EPSRC (Engineering and Physical Sciences Research Council)
1/08/06 → 31/01/12
Project: Research