Images in cardiovascular medicine: multiphoton microscopy for three-dimensional imaging of lymphocyte recruitment into apolipoprotein-E-deficient mouse carotid artery

P. Maffia, B.H. Zinselmeyer, A. Ialenti, S. Kennedy, A.H. Baker, I.B. McInnes, J.M. Brewer, P. Garside

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Two recent elegant studies have shown that in apolipoprotein-E– deficient mice, the lamina adventitia is a major site of arterial wall inflammation associated with lymphocyte infiltration into atherosclerotic arteries and with formation of adventitial lymphoid-like tissues.1,2 These results suggest that lymphocyte responses in the
lamina adventitia may play a crucial role in atherosclerosis development.1,2
Original languageEnglish
Pages (from-to)E326-E328
Number of pages3
Publication statusPublished - 2007


  • circulation
  • cardiovascular
  • multiphoton microscopy

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