IL‐6 knockout significantly attenuates angII hypertension, but not its salt sensitivity

Dexter L Lee, Katherine Lane, Hicham Labazi, Cassandra Fleming, Michael W Brands

Research output: Contribution to journalMeeting abstractpeer-review

Abstract

Previous results from our laboratory indicate that Interleukin-6 knockout (IL-6 KO) mice have a significantly lower mean arterial pressure (MAP) than wild-type (WT) mice during a high salt (HS) diet and AngII infusion, suggesting that IL-6 plays an important role in mediating the rightward shift in the renal pressure-natriuresis relationship caused by AngII. The goal of this study was to determine the salt-sensitivity of that effect. Male WT and IL-6 KO mice were implanted with biotelemetry devices and placed in metabolic cages to monitor MAP, water, food intake and urinary sodium excretion. Baseline MAP during a LS (.49% NaCl) diet was 112 ± 2.0 and 110 ± 2.6 mmHg, urinary sodium excretion was 0.35 ± 0.03 and 0.38 ± 0.05 mEq/2 days for WT and IL-6 KO mice, respectively. Baseline MAP during a HS (4% NaCl) diet was 114 ± 2.36 and 108 ± 3.0 mmHg, urinary sodium excretion was 2.8 ± 1.0 and 3.96 ± 0.3 mEq/2 days for WT and IL-6 KO mice, respectively. On day 5 of AngII (90 ng/min, s.c) and a LS diet, MAP reached 152 ± 7.0 and 134 ± 10 mmHg, urinary sodium excretion was not different during this period in WT and IL-6 KO mice, averaging 0.58± 0.12 and 0.69 ± 0.08 mEq/2 days, respectively. On day 5 of AngII and a HS diet, MAP reached 164 ± 2.0 (WT) and 146 ± 8.0 mmHg (IL-6 KO), urinary sodium excretion was 3.75 ± 0.8 and 4.39 ± 0.40 mEq/2 days for WT and IL-6 KO mice, respectively. These data confirm our previous report that knockout of IL-6 significantly attenuates AngII hypertension, and the parallel shift in the pressure-natriuresis relationship suggests, in addition, that this effect of IL-6 is not salt-sensitive.(HL7416, HL56259, HL75625, T32-HL66993)
Original languageEnglish
Pages (from-to) A310-A310
Number of pages1
JournalFASEB Journal
Volume20
Issue number4
DOIs
Publication statusPublished - 6 Mar 2006

Keywords

  • mean arterial pressure (MAP)
  • renal pressure-natriuresis relationship
  • salt-sensitivity
  • hypertension

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