Identification of nucleic acid sequences

Karen Faulds (Inventor), Duncan Graham (Inventor), William Smith (Inventor), Alastair Ricketts (Inventor)

Research output: Patent


The invention provides a method for use in the detection of a target nucleic acid comprising the steps of: (i) contacting a single-stranded probe nucleic acid with a sample of interest under conditions effective to generate a probe/target nucleic acid duplex by specific hybridisation of said probe nucleic acid to a target nucleic acid, if said nucleic acid is present; (ii) contacting any probe/target nucleic acid duplex with an exonuclease to effect digestion of the duplex and release of a label molecule from the duplex: and (ii) detecting the label by Raman spectroscopy.
Original languageEnglish
Patent numberWO 2009/022125 A1
IPCC12Q 1/68 (2006.1)
Publication statusPublished - 19 Feb 2009


  • Raman spectroscopy
  • nucleic acid sequences
  • spectroscopy


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