Hypertension linked to PDE3A activation

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A new study identifies PDE3A mutations as the cause of brachydactyly type E with hypertension. These mutations alter PDE3A activity by uncovering cryptic sites for phosphorylation by PKA and PKC, leading to enzyme hyperactivation that abnormally lowers cAMP levels.

Original languageEnglish
Pages (from-to)562-563
Number of pages2
JournalNature Genetics
Volume47
Issue number6
Early online date27 May 2015
DOIs
Publication statusPublished - Jun 2015

Fingerprint

Hypertension
Mutation
Phosphorylation
Enzymes
Brachydactyly with hypertension

Keywords

  • cyclic nucleotide phosphodiesterases, type 3
  • genetic association studies
  • genetic predisposition to disease
  • humans
  • hypertension

Cite this

Houslay, Miles. / Hypertension linked to PDE3A activation. In: Nature Genetics. 2015 ; Vol. 47, No. 6. pp. 562-563.
@article{b44726aba027455fa13870070c19b499,
title = "Hypertension linked to PDE3A activation",
abstract = "A new study identifies PDE3A mutations as the cause of brachydactyly type E with hypertension. These mutations alter PDE3A activity by uncovering cryptic sites for phosphorylation by PKA and PKC, leading to enzyme hyperactivation that abnormally lowers cAMP levels.",
keywords = "cyclic nucleotide phosphodiesterases, type 3, genetic association studies, genetic predisposition to disease, humans, hypertension",
author = "Miles Houslay",
year = "2015",
month = "6",
doi = "10.1038/ng.3316",
language = "English",
volume = "47",
pages = "562--563",
journal = "Nature Genetics",
issn = "1061-4036",
number = "6",

}

Hypertension linked to PDE3A activation. / Houslay, Miles.

In: Nature Genetics, Vol. 47, No. 6, 06.2015, p. 562-563.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Hypertension linked to PDE3A activation

AU - Houslay, Miles

PY - 2015/6

Y1 - 2015/6

N2 - A new study identifies PDE3A mutations as the cause of brachydactyly type E with hypertension. These mutations alter PDE3A activity by uncovering cryptic sites for phosphorylation by PKA and PKC, leading to enzyme hyperactivation that abnormally lowers cAMP levels.

AB - A new study identifies PDE3A mutations as the cause of brachydactyly type E with hypertension. These mutations alter PDE3A activity by uncovering cryptic sites for phosphorylation by PKA and PKC, leading to enzyme hyperactivation that abnormally lowers cAMP levels.

KW - cyclic nucleotide phosphodiesterases, type 3

KW - genetic association studies

KW - genetic predisposition to disease

KW - humans

KW - hypertension

U2 - 10.1038/ng.3316

DO - 10.1038/ng.3316

M3 - Article

VL - 47

SP - 562

EP - 563

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 6

ER -