Hypertension linked to PDE3A activation

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13 Citations (Scopus)


A new study identifies PDE3A mutations as the cause of brachydactyly type E with hypertension. These mutations alter PDE3A activity by uncovering cryptic sites for phosphorylation by PKA and PKC, leading to enzyme hyperactivation that abnormally lowers cAMP levels.

Original languageEnglish
Pages (from-to)562-563
Number of pages2
JournalNature Genetics
Issue number6
Early online date27 May 2015
Publication statusPublished - Jun 2015


  • cyclic nucleotide phosphodiesterases, type 3
  • genetic association studies
  • genetic predisposition to disease
  • humans
  • hypertension


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