Herein we present a range of substrates that undergo hydrogen isotope exchange with an iridium(I) NHC/phosphine complex bearing the less coordinating tetrakis[3,5-bis(trifluoromethyl)phenyl]borate counterion, and compare these with labelling using the equivalent, more established hexafluorophosphate complex. The changes in reactivity and selectivity of these complexes in a series of solvents are examined.
|Number of pages||4|
|Journal||Journal of Labelled Compounds and Radiopharmaceuticals|
|Early online date||27 Jul 2016|
|Publication status||Published - 31 Dec 2016|
- ortho-hydrogen isotope exchange
- N-heterocyclic carbene
Kerr, W. J., Mudd, R. J., Owens, P. K., Reid, M., Brown, J. A., & Campos, S. (2016). Hydrogen isotope exchange with highly active iridium(I) NHC/phosphine complexes: a comparative counter-ion study. Journal of Labelled Compounds and Radiopharmaceuticals, 59(14), 601-603. https://doi.org/10.1002/jlcr.3427