Abstract
Hydrogen atom transfer‐mediated intramolecular C−C coupling reactions between alkenes and nitriles, using PhSiH3 and catalytic Fe(acac)3, are described. This introduces a new strategic bond disconnection for ring‐closing reactions, forming ketones via imine intermediates. Of note is the scope of the reaction, including formation of sterically hindered ketones, spirocycles and fused cyclic systems.
Original language | English |
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Pages (from-to) | 18658–18662 |
Number of pages | 5 |
Journal | Chemistry - A European Journal |
Volume | 24 |
Issue number | 70 |
Early online date | 20 Oct 2018 |
DOIs | |
Publication status | Published - 12 Dec 2018 |
Keywords
- alkenes
- nitriles
- PhSiH3
- catalytic Fe(acac)3
- ring‐closing reactions
- iron‐mediated HAT reactions