Hydrogen atom transfer‐mediated cyclisations of nitriles

Oliver J. Turner, John A. Murphy, David J. Hirst, Eric P. A. Talbot

Research output: Contribution to journalArticle

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Abstract

Hydrogen atom transfer‐mediated intramolecular C−C coupling reactions between alkenes and nitriles, using PhSiH3 and catalytic Fe(acac)3, are described. This introduces a new strategic bond disconnection for ring‐closing reactions, forming ketones via imine intermediates. Of note is the scope of the reaction, including formation of sterically hindered ketones, spirocycles and fused cyclic systems.
Original languageEnglish
Pages (from-to)18658–18662
Number of pages5
JournalChemistry - A European Journal
Volume24
Issue number70
Early online date20 Oct 2018
DOIs
Publication statusPublished - 12 Dec 2018

Keywords

  • alkenes
  • nitriles
  • PhSiH3
  • catalytic Fe(acac)3
  • ring‐closing reactions
  • iron‐mediated HAT reactions

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