Hydrochlorothiazide N-methyl-2-pyrrolidone disolvate

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Hydrochlorothiazide forms a 1: 2 solvate with N-methylpyrrolidone (systematic name: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide N-methyl-2pyrrolidone disolvate), C7H8ClN3O4S2 center dot 2C(5)H(9)NO. The compound crystallizes with one hydrochlorothiazide and two solvent molecules, one of which is disordered, in the asymmetric unit. The crystal structure is isostructural with the previously reported hydrochlorothiazide N, N-dimethylacetamide disolvate.

LanguageEnglish
PagesO5169-O5171
Number of pages3
JournalActa Crystallographica Section E: Structure Reports
Volume62
DOIs
Publication statusPublished - Nov 2006

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Hydrochlorothiazide
dioxides
Crystal structure
crystal structure
Molecules
molecules
N-methylpyrrolidone
Sulfonamides

Keywords

  • hydrochlorothiazide
  • disolvates
  • crystallization

Cite this

@article{68ccc937f46f4365a85015de7b13b1ea,
title = "Hydrochlorothiazide N-methyl-2-pyrrolidone disolvate",
abstract = "Hydrochlorothiazide forms a 1: 2 solvate with N-methylpyrrolidone (systematic name: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide N-methyl-2pyrrolidone disolvate), C7H8ClN3O4S2 center dot 2C(5)H(9)NO. The compound crystallizes with one hydrochlorothiazide and two solvent molecules, one of which is disordered, in the asymmetric unit. The crystal structure is isostructural with the previously reported hydrochlorothiazide N, N-dimethylacetamide disolvate.",
keywords = "hydrochlorothiazide , disolvates, crystallization",
author = "Andrea Johnston and Florence, {Alastair J.} and Kennedy, {Alan R.}",
year = "2006",
month = "11",
doi = "10.1107/S1600536806042838",
language = "English",
volume = "62",
pages = "O5169--O5171",
journal = "Acta Crystallographica Section E: Structure Reports",
issn = "1600-5368",

}

Hydrochlorothiazide N-methyl-2-pyrrolidone disolvate. / Johnston, Andrea; Florence, Alastair J.; Kennedy, Alan R.

In: Acta Crystallographica Section E: Structure Reports, Vol. 62, 11.2006, p. O5169-O5171.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Hydrochlorothiazide N-methyl-2-pyrrolidone disolvate

AU - Johnston, Andrea

AU - Florence, Alastair J.

AU - Kennedy, Alan R.

PY - 2006/11

Y1 - 2006/11

N2 - Hydrochlorothiazide forms a 1: 2 solvate with N-methylpyrrolidone (systematic name: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide N-methyl-2pyrrolidone disolvate), C7H8ClN3O4S2 center dot 2C(5)H(9)NO. The compound crystallizes with one hydrochlorothiazide and two solvent molecules, one of which is disordered, in the asymmetric unit. The crystal structure is isostructural with the previously reported hydrochlorothiazide N, N-dimethylacetamide disolvate.

AB - Hydrochlorothiazide forms a 1: 2 solvate with N-methylpyrrolidone (systematic name: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide N-methyl-2pyrrolidone disolvate), C7H8ClN3O4S2 center dot 2C(5)H(9)NO. The compound crystallizes with one hydrochlorothiazide and two solvent molecules, one of which is disordered, in the asymmetric unit. The crystal structure is isostructural with the previously reported hydrochlorothiazide N, N-dimethylacetamide disolvate.

KW - hydrochlorothiazide

KW - disolvates

KW - crystallization

U2 - 10.1107/S1600536806042838

DO - 10.1107/S1600536806042838

M3 - Article

VL - 62

SP - O5169-O5171

JO - Acta Crystallographica Section E: Structure Reports

T2 - Acta Crystallographica Section E: Structure Reports

JF - Acta Crystallographica Section E: Structure Reports

SN - 1600-5368

ER -