Hydrochlorothiazide N-methyl-2-pyrrolidone disolvate

Andrea Johnston; Alastair J. Florence; Alan R. Kennedy

doi:10.1107/S1600536806042838

Hydrochlorothiazide N-methyl-2-pyrrolidone disolvate

Andrea Johnston, Alastair J. Florence, Alan R. Kennedy

Research output: Contribution to journal › Article

6 Citations (Scopus)

Abstract

Hydrochlorothiazide forms a 1: 2 solvate with N-methylpyrrolidone (systematic name: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide N-methyl-2pyrrolidone disolvate), C7H8ClN3O4S2 center dot 2C(5)H(9)NO. The compound crystallizes with one hydrochlorothiazide and two solvent molecules, one of which is disordered, in the asymmetric unit. The crystal structure is isostructural with the previously reported hydrochlorothiazide N, N-dimethylacetamide disolvate.

Original language	English
Pages (from-to)	O5169-O5171
Number of pages	3
Journal	Acta Crystallographica Section E: Structure Reports
Volume	62
DOIs	https://doi.org/10.1107/S1600536806042838
Publication status	Published - Nov 2006

Keywords

hydrochlorothiazide
disolvates
crystallization

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Johnston, A., Florence, A. J., & Kennedy, A. R. (2006). Hydrochlorothiazide N-methyl-2-pyrrolidone disolvate. Acta Crystallographica Section E: Structure Reports, 62, O5169-O5171. https://doi.org/10.1107/S1600536806042838

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title = "Hydrochlorothiazide N-methyl-2-pyrrolidone disolvate",

abstract = "Hydrochlorothiazide forms a 1: 2 solvate with N-methylpyrrolidone (systematic name: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide N-methyl-2pyrrolidone disolvate), C7H8ClN3O4S2 center dot 2C(5)H(9)NO. The compound crystallizes with one hydrochlorothiazide and two solvent molecules, one of which is disordered, in the asymmetric unit. The crystal structure is isostructural with the previously reported hydrochlorothiazide N, N-dimethylacetamide disolvate.",

keywords = "hydrochlorothiazide , disolvates, crystallization",

author = "Andrea Johnston and Florence, {Alastair J.} and Kennedy, {Alan R.}",

year = "2006",

month = "11",

doi = "10.1107/S1600536806042838",

language = "English",

volume = "62",

pages = "O5169--O5171",

journal = "Acta Crystallographica Section E: Structure Reports",

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TY - JOUR

T1 - Hydrochlorothiazide N-methyl-2-pyrrolidone disolvate

AU - Johnston, Andrea

AU - Florence, Alastair J.

AU - Kennedy, Alan R.

PY - 2006/11

Y1 - 2006/11

N2 - Hydrochlorothiazide forms a 1: 2 solvate with N-methylpyrrolidone (systematic name: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide N-methyl-2pyrrolidone disolvate), C7H8ClN3O4S2 center dot 2C(5)H(9)NO. The compound crystallizes with one hydrochlorothiazide and two solvent molecules, one of which is disordered, in the asymmetric unit. The crystal structure is isostructural with the previously reported hydrochlorothiazide N, N-dimethylacetamide disolvate.

AB - Hydrochlorothiazide forms a 1: 2 solvate with N-methylpyrrolidone (systematic name: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide N-methyl-2pyrrolidone disolvate), C7H8ClN3O4S2 center dot 2C(5)H(9)NO. The compound crystallizes with one hydrochlorothiazide and two solvent molecules, one of which is disordered, in the asymmetric unit. The crystal structure is isostructural with the previously reported hydrochlorothiazide N, N-dimethylacetamide disolvate.

KW - hydrochlorothiazide

KW - disolvates

KW - crystallization

U2 - 10.1107/S1600536806042838

DO - 10.1107/S1600536806042838

M3 - Article

VL - 62

SP - O5169-O5171

JO - Acta Crystallographica Section E: Structure Reports

JF - Acta Crystallographica Section E: Structure Reports

SN - 1600-5368

ER -