Abstract
Hydrochlorothiazide forms a 1: 2 solvate with N-methylpyrrolidone (systematic name: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide N-methyl-2pyrrolidone disolvate), C7H8ClN3O4S2 center dot 2C(5)H(9)NO. The compound crystallizes with one hydrochlorothiazide and two solvent molecules, one of which is disordered, in the asymmetric unit. The crystal structure is isostructural with the previously reported hydrochlorothiazide N, N-dimethylacetamide disolvate.
| Language | English |
|---|---|
| Pages | O5169-O5171 |
| Number of pages | 3 |
| Journal | Acta Crystallographica Section E: Structure Reports |
| Volume | 62 |
| DOIs | |
| Publication status | Published - Nov 2006 |
Fingerprint
Keywords
- hydrochlorothiazide
- disolvates
- crystallization
Cite this
}
Hydrochlorothiazide N-methyl-2-pyrrolidone disolvate. / Johnston, Andrea; Florence, Alastair J.; Kennedy, Alan R.
In: Acta Crystallographica Section E: Structure Reports, Vol. 62, 11.2006, p. O5169-O5171.Research output: Contribution to journal › Article
TY - JOUR
T1 - Hydrochlorothiazide N-methyl-2-pyrrolidone disolvate
AU - Johnston, Andrea
AU - Florence, Alastair J.
AU - Kennedy, Alan R.
PY - 2006/11
Y1 - 2006/11
N2 - Hydrochlorothiazide forms a 1: 2 solvate with N-methylpyrrolidone (systematic name: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide N-methyl-2pyrrolidone disolvate), C7H8ClN3O4S2 center dot 2C(5)H(9)NO. The compound crystallizes with one hydrochlorothiazide and two solvent molecules, one of which is disordered, in the asymmetric unit. The crystal structure is isostructural with the previously reported hydrochlorothiazide N, N-dimethylacetamide disolvate.
AB - Hydrochlorothiazide forms a 1: 2 solvate with N-methylpyrrolidone (systematic name: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide N-methyl-2pyrrolidone disolvate), C7H8ClN3O4S2 center dot 2C(5)H(9)NO. The compound crystallizes with one hydrochlorothiazide and two solvent molecules, one of which is disordered, in the asymmetric unit. The crystal structure is isostructural with the previously reported hydrochlorothiazide N, N-dimethylacetamide disolvate.
KW - hydrochlorothiazide
KW - disolvates
KW - crystallization
U2 - 10.1107/S1600536806042838
DO - 10.1107/S1600536806042838
M3 - Article
VL - 62
SP - O5169-O5171
JO - Acta Crystallographica Section E: Structure Reports
T2 - Acta Crystallographica Section E: Structure Reports
JF - Acta Crystallographica Section E: Structure Reports
SN - 1600-5368
ER -