Hydrochlorothiazide-1,4-dioxane(1/1)

A  Johnston; A J  Florence; A R  Kennedy

doi:10.1107/S1600536805022464

Hydrochlorothiazide-1,4-dioxane(1/1)

A Johnston, A J Florence, A R Kennedy

Research output: Contribution to journal › Article

4 Citations (Scopus)

Abstract

Hydrochlorothiazide forms a 1:1 solvate with 1,4-dioxane, C(7)H(8)ClN(3)O(4)S(2)center dot C4H8O2 [systematic name: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide-1,4-dioxane (1/1)]. The asymmetric unit comprises one molecule of hydrochlorothiazide and halves of two solvent molecules arranged around inversion centres. The structure contains a hydrogen-bonding network comprising three N-H center dot center dot center dot O and one N-H center dot center dot center dot N hydrogen bonds.

Original language	English
Pages (from-to)	O2573-O2575
Number of pages	3
Journal	Acta Crystallographica Section E: Structure Reports
Volume	61
DOIs	https://doi.org/10.1107/S1600536805022464
Publication status	Published - Aug 2005

Keywords

crystal structures
hydrochlorothiazide
solvent molecules

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10.1107/S1600536805022464

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Equipment

x-ray diffractometer

Alan Kennedy (Manager)

Pure And Applied Chemistry

Facility/equipment: Equipment

Cite this

Johnston, A., Florence, A. J., & Kennedy, A. R. (2005). Hydrochlorothiazide-1,4-dioxane(1/1). Acta Crystallographica Section E: Structure Reports, 61, O2573-O2575. https://doi.org/10.1107/S1600536805022464

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title = "Hydrochlorothiazide-1,4-dioxane(1/1)",

abstract = "Hydrochlorothiazide forms a 1:1 solvate with 1,4-dioxane, C(7)H(8)ClN(3)O(4)S(2)center dot C4H8O2 [systematic name: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide-1,4-dioxane (1/1)]. The asymmetric unit comprises one molecule of hydrochlorothiazide and halves of two solvent molecules arranged around inversion centres. The structure contains a hydrogen-bonding network comprising three N-H center dot center dot center dot O and one N-H center dot center dot center dot N hydrogen bonds.",

keywords = "crystal structures, hydrochlorothiazide, solvent molecules",

author = "A Johnston and Florence, {A J} and Kennedy, {A R}",

year = "2005",

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doi = "10.1107/S1600536805022464",

language = "English",

volume = "61",

pages = "O2573--O2575",

journal = "Acta Crystallographica Section E: Structure Reports",

issn = "1600-5368",

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TY - JOUR

T1 - Hydrochlorothiazide-1,4-dioxane(1/1)

AU - Johnston, A

AU - Florence, A J

AU - Kennedy, A R

PY - 2005/8

Y1 - 2005/8

N2 - Hydrochlorothiazide forms a 1:1 solvate with 1,4-dioxane, C(7)H(8)ClN(3)O(4)S(2)center dot C4H8O2 [systematic name: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide-1,4-dioxane (1/1)]. The asymmetric unit comprises one molecule of hydrochlorothiazide and halves of two solvent molecules arranged around inversion centres. The structure contains a hydrogen-bonding network comprising three N-H center dot center dot center dot O and one N-H center dot center dot center dot N hydrogen bonds.

AB - Hydrochlorothiazide forms a 1:1 solvate with 1,4-dioxane, C(7)H(8)ClN(3)O(4)S(2)center dot C4H8O2 [systematic name: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide-1,4-dioxane (1/1)]. The asymmetric unit comprises one molecule of hydrochlorothiazide and halves of two solvent molecules arranged around inversion centres. The structure contains a hydrogen-bonding network comprising three N-H center dot center dot center dot O and one N-H center dot center dot center dot N hydrogen bonds.

KW - crystal structures

KW - hydrochlorothiazide

KW - solvent molecules

U2 - 10.1107/S1600536805022464

DO - 10.1107/S1600536805022464

M3 - Article

VL - 61

SP - O2573-O2575

JO - Acta Crystallographica Section E: Structure Reports

JF - Acta Crystallographica Section E: Structure Reports

SN - 1600-5368

ER -