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Hydrochlorothiazide forms a 1:1 solvate with 1,4-dioxane, C(7)H(8)ClN(3)O(4)S(2)center dot C4H8O2 [systematic name: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide-1,4-dioxane (1/1)]. The asymmetric unit comprises one molecule of hydrochlorothiazide and halves of two solvent molecules arranged around inversion centres. The structure contains a hydrogen-bonding network comprising three N-H center dot center dot center dot O and one N-H center dot center dot center dot N hydrogen bonds.

Original languageEnglish
Pages (from-to)O2573-O2575
Number of pages3
JournalActa Crystallographica Section E: Structure Reports
Publication statusPublished - Aug 2005


  • crystal structures
  • hydrochlorothiazide
  • solvent molecules

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