Abstract
Hydrochlorothiazide forms a 1:1 solvate with 1,4-dioxane, C(7)H(8)ClN(3)O(4)S(2)center dot C4H8O2 [systematic name: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide-1,4-dioxane (1/1)]. The asymmetric unit comprises one molecule of hydrochlorothiazide and halves of two solvent molecules arranged around inversion centres. The structure contains a hydrogen-bonding network comprising three N-H center dot center dot center dot O and one N-H center dot center dot center dot N hydrogen bonds.
| Language | English |
|---|---|
| Pages | O2573-O2575 |
| Number of pages | 3 |
| Journal | Acta Crystallographica Section E: Structure Reports |
| Volume | 61 |
| DOIs | |
| Publication status | Published - Aug 2005 |
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Keywords
- crystal structures
- hydrochlorothiazide
- solvent molecules
Cite this
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Hydrochlorothiazide-1,4-dioxane(1/1). / Johnston, A ; Florence, A J ; Kennedy, A R .
In: Acta Crystallographica Section E: Structure Reports, Vol. 61, 08.2005, p. O2573-O2575.Research output: Contribution to journal › Article
TY - JOUR
T1 - Hydrochlorothiazide-1,4-dioxane(1/1)
AU - Johnston, A
AU - Florence, A J
AU - Kennedy, A R
PY - 2005/8
Y1 - 2005/8
N2 - Hydrochlorothiazide forms a 1:1 solvate with 1,4-dioxane, C(7)H(8)ClN(3)O(4)S(2)center dot C4H8O2 [systematic name: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide-1,4-dioxane (1/1)]. The asymmetric unit comprises one molecule of hydrochlorothiazide and halves of two solvent molecules arranged around inversion centres. The structure contains a hydrogen-bonding network comprising three N-H center dot center dot center dot O and one N-H center dot center dot center dot N hydrogen bonds.
AB - Hydrochlorothiazide forms a 1:1 solvate with 1,4-dioxane, C(7)H(8)ClN(3)O(4)S(2)center dot C4H8O2 [systematic name: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide-1,4-dioxane (1/1)]. The asymmetric unit comprises one molecule of hydrochlorothiazide and halves of two solvent molecules arranged around inversion centres. The structure contains a hydrogen-bonding network comprising three N-H center dot center dot center dot O and one N-H center dot center dot center dot N hydrogen bonds.
KW - crystal structures
KW - hydrochlorothiazide
KW - solvent molecules
U2 - 10.1107/S1600536805022464
DO - 10.1107/S1600536805022464
M3 - Article
VL - 61
SP - O2573-O2575
JO - Acta Crystallographica Section E: Structure Reports
T2 - Acta Crystallographica Section E: Structure Reports
JF - Acta Crystallographica Section E: Structure Reports
SN - 1600-5368
ER -