Hydrochlorothiazide-1,4-dioxane(1/1)

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Hydrochlorothiazide forms a 1:1 solvate with 1,4-dioxane, C(7)H(8)ClN(3)O(4)S(2)center dot C4H8O2 [systematic name: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide-1,4-dioxane (1/1)]. The asymmetric unit comprises one molecule of hydrochlorothiazide and halves of two solvent molecules arranged around inversion centres. The structure contains a hydrogen-bonding network comprising three N-H center dot center dot center dot O and one N-H center dot center dot center dot N hydrogen bonds.

LanguageEnglish
PagesO2573-O2575
Number of pages3
JournalActa Crystallographica Section E: Structure Reports
Volume61
DOIs
Publication statusPublished - Aug 2005

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Hydrochlorothiazide
Hydrogen bonds
Molecules
1,4-dioxane
dioxides
molecules
inversions
hydrogen bonds
Sulfonamides
hydrogen

Keywords

  • crystal structures
  • hydrochlorothiazide
  • solvent molecules

Cite this

@article{87f883f048c040e7accffbbf12260bbf,
title = "Hydrochlorothiazide-1,4-dioxane(1/1)",
abstract = "Hydrochlorothiazide forms a 1:1 solvate with 1,4-dioxane, C(7)H(8)ClN(3)O(4)S(2)center dot C4H8O2 [systematic name: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide-1,4-dioxane (1/1)]. The asymmetric unit comprises one molecule of hydrochlorothiazide and halves of two solvent molecules arranged around inversion centres. The structure contains a hydrogen-bonding network comprising three N-H center dot center dot center dot O and one N-H center dot center dot center dot N hydrogen bonds.",
keywords = "crystal structures, hydrochlorothiazide, solvent molecules",
author = "A Johnston and Florence, {A J} and Kennedy, {A R}",
year = "2005",
month = "8",
doi = "10.1107/S1600536805022464",
language = "English",
volume = "61",
pages = "O2573--O2575",
journal = "Acta Crystallographica Section E: Structure Reports",
issn = "1600-5368",

}

Hydrochlorothiazide-1,4-dioxane(1/1). / Johnston, A ; Florence, A J ; Kennedy, A R .

In: Acta Crystallographica Section E: Structure Reports, Vol. 61, 08.2005, p. O2573-O2575.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Hydrochlorothiazide-1,4-dioxane(1/1)

AU - Johnston, A

AU - Florence, A J

AU - Kennedy, A R

PY - 2005/8

Y1 - 2005/8

N2 - Hydrochlorothiazide forms a 1:1 solvate with 1,4-dioxane, C(7)H(8)ClN(3)O(4)S(2)center dot C4H8O2 [systematic name: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide-1,4-dioxane (1/1)]. The asymmetric unit comprises one molecule of hydrochlorothiazide and halves of two solvent molecules arranged around inversion centres. The structure contains a hydrogen-bonding network comprising three N-H center dot center dot center dot O and one N-H center dot center dot center dot N hydrogen bonds.

AB - Hydrochlorothiazide forms a 1:1 solvate with 1,4-dioxane, C(7)H(8)ClN(3)O(4)S(2)center dot C4H8O2 [systematic name: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide-1,4-dioxane (1/1)]. The asymmetric unit comprises one molecule of hydrochlorothiazide and halves of two solvent molecules arranged around inversion centres. The structure contains a hydrogen-bonding network comprising three N-H center dot center dot center dot O and one N-H center dot center dot center dot N hydrogen bonds.

KW - crystal structures

KW - hydrochlorothiazide

KW - solvent molecules

U2 - 10.1107/S1600536805022464

DO - 10.1107/S1600536805022464

M3 - Article

VL - 61

SP - O2573-O2575

JO - Acta Crystallographica Section E: Structure Reports

T2 - Acta Crystallographica Section E: Structure Reports

JF - Acta Crystallographica Section E: Structure Reports

SN - 1600-5368

ER -