Hybrid gold-iron oxide nanoparticles as a multifunctional platform for biomedical application

Clare Hoskins; Yue Min; Mariana Gueorguieva; Craig MacDougall; Alexander Volvick; Paul Prentice; Zhigang Wang; Andreas Melzer; Alfred Cuschieri; Lijun Wang

doi:10.1186/1477-3155-10-27

Hybrid gold-iron oxide nanoparticles as a multifunctional platform for biomedical application

Clare Hoskins, Yue Min, Mariana Gueorguieva, Craig MacDougall, Alexander Volvick, Paul Prentice, Zhigang Wang, Andreas Melzer, Alfred Cuschieri, Lijun Wang

Pure And Applied Chemistry

Research output: Contribution to journal › Article › peer-review

112 Citations (Scopus)

Abstract

Background: Iron oxide nanoparticles (IONPs) have increasing applications in biomedicine, however fears over long
term stability of polymer coated particles have arisen. Gold coating IONPs results in particles of increased stability
and robustness. The unique properties of both the iron oxide (magnetic) and gold (surface plasmon resonance)
result in a multimodal platform for use as MRI contrast agents and as a nano-heater.
Results: Here we synthesize IONPs of core diameter 30 nm and gold coat using the seeding method with a poly
(ethylenimine) intermediate layer. The final particles were coated in poly(ethylene glycol) to ensure biocompatibility
and increase retention times in vivo. The particle coating was monitored using FTIR, PCS, UV–vis absorption, TEM,
and EDX. The particles appeared to have little cytotoxic effect when incubated with A375M cells. The resultant
hybrid nanoparticles (HNPs) possessed a maximal absorbance at 600 nm. After laser irradiation in agar phantom a
ΔT of 32°C was achieved after only 90 s exposure (50 μgmL-1). The HNPs appeared to decrease T2 values in line
with previously clinically used MRI contrast agent FeridexW.
Conclusions: The data highlights the potential of these HNPs as dual function MRI contrast agents and nanoheaters for therapies such as cellular hyperthermia or thermo-responsive drug delivery

Original language	English
Article number	27
Number of pages	12
Journal	Journal of Nanobiotechnology
Volume	10
DOIs	https://doi.org/10.1186/1477-3155-10-27
Publication status	E-pub ahead of print - 25 Jun 2012

Keywords

magnetic nanoparticles
gold nano-shells
magnetic resonance imaging
, surface plasmon resonance
multifunctional nanoparticles

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title = "Hybrid gold-iron oxide nanoparticles as a multifunctional platform for biomedical application",

abstract = "Background: Iron oxide nanoparticles (IONPs) have increasing applications in biomedicine, however fears over longterm stability of polymer coated particles have arisen. Gold coating IONPs results in particles of increased stabilityand robustness. The unique properties of both the iron oxide (magnetic) and gold (surface plasmon resonance)result in a multimodal platform for use as MRI contrast agents and as a nano-heater.Results: Here we synthesize IONPs of core diameter 30 nm and gold coat using the seeding method with a poly(ethylenimine) intermediate layer. The final particles were coated in poly(ethylene glycol) to ensure biocompatibilityand increase retention times in vivo. The particle coating was monitored using FTIR, PCS, UV–vis absorption, TEM,and EDX. The particles appeared to have little cytotoxic effect when incubated with A375M cells. The resultanthybrid nanoparticles (HNPs) possessed a maximal absorbance at 600 nm. After laser irradiation in agar phantom aΔT of 32°C was achieved after only 90 s exposure (50 μgmL-1). The HNPs appeared to decrease T2 values in linewith previously clinically used MRI contrast agent FeridexW.Conclusions: The data highlights the potential of these HNPs as dual function MRI contrast agents and nanoheaters for therapies such as cellular hyperthermia or thermo-responsive drug delivery",

keywords = "magnetic nanoparticles, gold nano-shells, magnetic resonance imaging, , surface plasmon resonance, multifunctional nanoparticles",

author = "Clare Hoskins and Yue Min and Mariana Gueorguieva and Craig MacDougall and Alexander Volvick and Paul Prentice and Zhigang Wang and Andreas Melzer and Alfred Cuschieri and Lijun Wang",

year = "2012",

month = jun,

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doi = "10.1186/1477-3155-10-27",

language = "English",

volume = "10",

journal = "Journal of Nanobiotechnology",

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T1 - Hybrid gold-iron oxide nanoparticles as a multifunctional platform for biomedical application

AU - Hoskins, Clare

AU - Min, Yue

AU - Gueorguieva, Mariana

AU - MacDougall, Craig

AU - Volvick, Alexander

AU - Prentice, Paul

AU - Wang, Zhigang

AU - Melzer, Andreas

AU - Cuschieri, Alfred

AU - Wang, Lijun

PY - 2012/6/25

Y1 - 2012/6/25

N2 - Background: Iron oxide nanoparticles (IONPs) have increasing applications in biomedicine, however fears over longterm stability of polymer coated particles have arisen. Gold coating IONPs results in particles of increased stabilityand robustness. The unique properties of both the iron oxide (magnetic) and gold (surface plasmon resonance)result in a multimodal platform for use as MRI contrast agents and as a nano-heater.Results: Here we synthesize IONPs of core diameter 30 nm and gold coat using the seeding method with a poly(ethylenimine) intermediate layer. The final particles were coated in poly(ethylene glycol) to ensure biocompatibilityand increase retention times in vivo. The particle coating was monitored using FTIR, PCS, UV–vis absorption, TEM,and EDX. The particles appeared to have little cytotoxic effect when incubated with A375M cells. The resultanthybrid nanoparticles (HNPs) possessed a maximal absorbance at 600 nm. After laser irradiation in agar phantom aΔT of 32°C was achieved after only 90 s exposure (50 μgmL-1). The HNPs appeared to decrease T2 values in linewith previously clinically used MRI contrast agent FeridexW.Conclusions: The data highlights the potential of these HNPs as dual function MRI contrast agents and nanoheaters for therapies such as cellular hyperthermia or thermo-responsive drug delivery

AB - Background: Iron oxide nanoparticles (IONPs) have increasing applications in biomedicine, however fears over longterm stability of polymer coated particles have arisen. Gold coating IONPs results in particles of increased stabilityand robustness. The unique properties of both the iron oxide (magnetic) and gold (surface plasmon resonance)result in a multimodal platform for use as MRI contrast agents and as a nano-heater.Results: Here we synthesize IONPs of core diameter 30 nm and gold coat using the seeding method with a poly(ethylenimine) intermediate layer. The final particles were coated in poly(ethylene glycol) to ensure biocompatibilityand increase retention times in vivo. The particle coating was monitored using FTIR, PCS, UV–vis absorption, TEM,and EDX. The particles appeared to have little cytotoxic effect when incubated with A375M cells. The resultanthybrid nanoparticles (HNPs) possessed a maximal absorbance at 600 nm. After laser irradiation in agar phantom aΔT of 32°C was achieved after only 90 s exposure (50 μgmL-1). The HNPs appeared to decrease T2 values in linewith previously clinically used MRI contrast agent FeridexW.Conclusions: The data highlights the potential of these HNPs as dual function MRI contrast agents and nanoheaters for therapies such as cellular hyperthermia or thermo-responsive drug delivery

KW - magnetic nanoparticles

KW - gold nano-shells

KW - magnetic resonance imaging

KW - , surface plasmon resonance

KW - multifunctional nanoparticles

U2 - 10.1186/1477-3155-10-27

DO - 10.1186/1477-3155-10-27

M3 - Article

SN - 1477-3155

VL - 10

JO - Journal of Nanobiotechnology

JF - Journal of Nanobiotechnology

M1 - 27

ER -

Hybrid gold-iron oxide nanoparticles as a multifunctional platform for biomedical application

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Keywords

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