Human serum albumin-flavonoid interactions monitored by means of tryptophan kinetics

O.J. Rolinski; A. Martin; D.J.S. Birch

Human serum albumin-flavonoid interactions monitored by means of tryptophan kinetics

O.J. Rolinski
, A. Martin
, D.J.S. Birch

Research output: Contribution to journal › Article › peer-review

Abstract

A nonextensive model of decay kinetics has been used to describe fluorescence behavior of tryptophan in human serum albumin on binding two flavonoids, quercetin and morin. We demonstrate that this approach, alternative to multiexponential representation of usually complex decays of tryptophan, is more adequate and can be beneficial in noninvasive lifetime sensing based on intrinsic fluorescence. (Abstract from WOK)

Original language	English
Pages (from-to)	314-319
Number of pages	5
Journal	Annals of the New York Academy of Sciences
Volume	1130
Publication status	Published - 2008

Keywords

HSA
tryptophan
fluorescence decays
nonextensive kinetics
lifetime distribution
flavonoids

NMS: EPSRC Science and Innovation Nanometrology for Molecular Science, Medicine and Manufacture
Birch, D. (Principal Investigator), Dawson, M. (Co-investigator), Faulds, K. (Co-investigator), Girkin, J. (Co-investigator), Graham, D. (Co-investigator), Martin, R. (Co-investigator), O'Donnell, K. (Co-investigator), Rolinski, O. (Co-investigator), Smith, W. (Co-investigator) & Wynne, K. (Co-investigator)
Scottish Funding Council SFC, EPSRC (Engineering and Physical Sciences Research Council)
1/08/08 → 31/01/12
Project: Research

Cite this

@article{78334463ed4547f792eed97ce1863cc0,

title = "Human serum albumin-flavonoid interactions monitored by means of tryptophan kinetics",

abstract = "A nonextensive model of decay kinetics has been used to describe fluorescence behavior of tryptophan in human serum albumin on binding two flavonoids, quercetin and morin. We demonstrate that this approach, alternative to multiexponential representation of usually complex decays of tryptophan, is more adequate and can be beneficial in noninvasive lifetime sensing based on intrinsic fluorescence. (Abstract from WOK)",

keywords = "HSA, tryptophan, fluorescence decays, nonextensive kinetics, lifetime distribution, flavonoids",

author = "O.J. Rolinski and A. Martin and D.J.S. Birch",

year = "2008",

language = "English",

volume = "1130",

pages = "314--319",

journal = "Annals of the New York Academy of Sciences",

issn = "0077-8923",

publisher = "John Wiley and Sons Inc.",

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TY - JOUR

T1 - Human serum albumin-flavonoid interactions monitored by means of tryptophan kinetics

AU - Rolinski, O.J.

AU - Martin, A.

AU - Birch, D.J.S.

PY - 2008

Y1 - 2008

N2 - A nonextensive model of decay kinetics has been used to describe fluorescence behavior of tryptophan in human serum albumin on binding two flavonoids, quercetin and morin. We demonstrate that this approach, alternative to multiexponential representation of usually complex decays of tryptophan, is more adequate and can be beneficial in noninvasive lifetime sensing based on intrinsic fluorescence. (Abstract from WOK)

AB - A nonextensive model of decay kinetics has been used to describe fluorescence behavior of tryptophan in human serum albumin on binding two flavonoids, quercetin and morin. We demonstrate that this approach, alternative to multiexponential representation of usually complex decays of tryptophan, is more adequate and can be beneficial in noninvasive lifetime sensing based on intrinsic fluorescence. (Abstract from WOK)

KW - HSA

KW - tryptophan

KW - fluorescence decays

KW - nonextensive kinetics

KW - lifetime distribution

KW - flavonoids

M3 - Article

SN - 0077-8923

VL - 1130

SP - 314

EP - 319

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

Human serum albumin-flavonoid interactions monitored by means of tryptophan kinetics

Abstract

Keywords

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Projects

NMS: EPSRC Science and Innovation Nanometrology for Molecular Science, Medicine and Manufacture

Cite this