Human resting eHsp72 concentration decreases during the initial adaptation to exercise in a hot humid environment

H.C. Marshall, R.A. Ferguson, M.A. Nimmo

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Heat shock protein (Hsp) 72 is a cytosolic protein that also is present in the circulation. Extracellular Hsp72 (eHsp72) is inducible by exercise and is suggested to act as a danger signal to the immune system. The adaptive response of eHsp72 to repeated exercise-heat exposures in humans remains to be determined. An intracellular animal study found a reduced Hsp72 response, with no change in resting levels, during heat stress after a single day of passive heat acclimation. The current study therefore tested whether adaptations in human eHsp72 levels would similarly occur 24 hours after a single exercise-heat exposure. Seven males completed cycle exercise (42.5% O2peak for 2 hours) in a hot, humid environment (38°C, 60% relative humidity) on each of 2 consecutive days. Blood samples were obtained from an antecubital vein before exercise and 0 hours and 22 hours postexercise for the analysis of eHsp72. Exercise-heat stress resulted in enhanced eHsp72, with a similar absolute increase found on both days (day 1: 1.26 ng/mL [0.80 ng/mL]; day 2: 1.29 ng/mL [1.60 ng/mL]). Resting eHsp72 decreased from rest on day 1 to day 2's 22-hour postexercise sample (P < 0.05). It is suggested that the reduction in resting eHsp72 after 2 consecutive exercise-heat exposures is possibly due to an enhanced removal from the circulation, for either immunoregulatory functions, or for improved cellular stress tolerance in this initial, most stressful period of acclimation.
LanguageEnglish
Pages129-134
Number of pages5
JournalCell Stress and Chaperones
Volume11
Issue number2
DOIs
Publication statusPublished - 2006

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Hot Temperature
Acclimatization
HSP72 Heat-Shock Proteins
Immune system
Humidity
Veins
Immune System
Atmospheric humidity
Animals
Blood
Proteins

Keywords

  • cells
  • pharmacological science
  • biomedicine
  • physiology

Cite this

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abstract = "Heat shock protein (Hsp) 72 is a cytosolic protein that also is present in the circulation. Extracellular Hsp72 (eHsp72) is inducible by exercise and is suggested to act as a danger signal to the immune system. The adaptive response of eHsp72 to repeated exercise-heat exposures in humans remains to be determined. An intracellular animal study found a reduced Hsp72 response, with no change in resting levels, during heat stress after a single day of passive heat acclimation. The current study therefore tested whether adaptations in human eHsp72 levels would similarly occur 24 hours after a single exercise-heat exposure. Seven males completed cycle exercise (42.5{\%} O2peak for 2 hours) in a hot, humid environment (38°C, 60{\%} relative humidity) on each of 2 consecutive days. Blood samples were obtained from an antecubital vein before exercise and 0 hours and 22 hours postexercise for the analysis of eHsp72. Exercise-heat stress resulted in enhanced eHsp72, with a similar absolute increase found on both days (day 1: 1.26 ng/mL [0.80 ng/mL]; day 2: 1.29 ng/mL [1.60 ng/mL]). Resting eHsp72 decreased from rest on day 1 to day 2's 22-hour postexercise sample (P < 0.05). It is suggested that the reduction in resting eHsp72 after 2 consecutive exercise-heat exposures is possibly due to an enhanced removal from the circulation, for either immunoregulatory functions, or for improved cellular stress tolerance in this initial, most stressful period of acclimation.",
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Human resting eHsp72 concentration decreases during the initial adaptation to exercise in a hot humid environment. / Marshall, H.C.; Ferguson, R.A.; Nimmo, M.A.

In: Cell Stress and Chaperones, Vol. 11, No. 2, 2006, p. 129-134.

Research output: Contribution to journalArticle

TY - JOUR

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AU - Nimmo, M.A.

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