How hosts control worms

M.J. Stear; K. Bairden; J.L. Duncan; P.H. Holmes; Q.A. McKellar; M. Park; S. Strain; G. Gettinby

doi:10.1038/37895

How hosts control worms

M.J. Stear, K. Bairden, J.L. Duncan, P.H. Holmes, Q.A. McKellar, M. Park, S. Strain, G. Gettinby

Mathematics And Statistics

Research output: Contribution to journal › Article › peer-review

95 Citations (Scopus)

Abstract

Nematodes are a major cause of disease and death in humans, domestic animals and wildlife. Understanding why some individuals suffer severely whereas others exposed to the same infection remain healthy may assist in the development of rational and sustainable strategies to control infection. Here, using a quantitative genetic analysis of the parasitic nematode population that had accumulated naturally in lambs, we find no apparent influence of host genetics on nematode numbers but an extremely strong influence on average worm length and fecundity. Our results indicate that in growing lambs the main manifestation of genetic resistance is the control of worm fecundity.

Original language	English
Pages (from-to)	27-27
Number of pages	0
Journal	Nature
Volume	389
Issue number	6646
DOIs	https://doi.org/10.1038/37895
Publication status	Published - 4 Sept 1997

Keywords

nematodes
worm fecundity
genetic resistance
lamb

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10.1038/37895

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title = "How hosts control worms",

abstract = "Nematodes are a major cause of disease and death in humans, domestic animals and wildlife. Understanding why some individuals suffer severely whereas others exposed to the same infection remain healthy may assist in the development of rational and sustainable strategies to control infection. Here, using a quantitative genetic analysis of the parasitic nematode population that had accumulated naturally in lambs, we find no apparent influence of host genetics on nematode numbers but an extremely strong influence on average worm length and fecundity. Our results indicate that in growing lambs the main manifestation of genetic resistance is the control of worm fecundity.",

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AU - Stear, M.J.

AU - Bairden, K.

AU - Duncan, J.L.

AU - Holmes, P.H.

AU - McKellar, Q.A.

AU - Park, M.

AU - Strain, S.

AU - Gettinby, G.

N1 - Strathprints' policy is to record up to 8 authors per publication, plus any additional authors based at the University of Strathclyde. More authors may be listed on the official publication than appear in the Strathprints' record.

PY - 1997/9/4

Y1 - 1997/9/4

N2 - Nematodes are a major cause of disease and death in humans, domestic animals and wildlife. Understanding why some individuals suffer severely whereas others exposed to the same infection remain healthy may assist in the development of rational and sustainable strategies to control infection. Here, using a quantitative genetic analysis of the parasitic nematode population that had accumulated naturally in lambs, we find no apparent influence of host genetics on nematode numbers but an extremely strong influence on average worm length and fecundity. Our results indicate that in growing lambs the main manifestation of genetic resistance is the control of worm fecundity.

AB - Nematodes are a major cause of disease and death in humans, domestic animals and wildlife. Understanding why some individuals suffer severely whereas others exposed to the same infection remain healthy may assist in the development of rational and sustainable strategies to control infection. Here, using a quantitative genetic analysis of the parasitic nematode population that had accumulated naturally in lambs, we find no apparent influence of host genetics on nematode numbers but an extremely strong influence on average worm length and fecundity. Our results indicate that in growing lambs the main manifestation of genetic resistance is the control of worm fecundity.

KW - nematodes

KW - worm fecundity

KW - genetic resistance

KW - lamb

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U2 - 10.1038/37895

DO - 10.1038/37895

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SN - 0028-0836

VL - 389

SP - 27

EP - 27

JO - Nature

JF - Nature

IS - 6646

ER -

How hosts control worms

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Keywords

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