How does toxoplasmosis affect the maternal-foetal immune interface and pregnancy?

Margarida Borges, Tânia Magalhães Silva, Carina Brito, Natércia Teixeira, Craig W. Roberts

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4 Citations (Scopus)
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Abstract

Toxoplasma gondii is a zoonotic parasite which, depending on the geographical location, can infect between 10 to 90% of humans. Infection during pregnancy mayresult in congenital toxoplasmosis. The effects on the fetus vary depending on the stage of gestation in which primary maternal infection arises. A large body of research has focused on understanding immune response to toxoplasmosis, although few studies have addressed how it is affected by pregnancy or the pathological consequences of infection at the maternal-fetal interface. There isa lack of knowledge about how maternal immune cells, specifically macrophages are modulated during infection and the resulting consequences for parasite control and pathology. Herein, we discuss the potential of T. gondii infection to affect the maternal-fetal interface and the potential of pregnancy to disrupt maternal immunity to T. gondii infection.
Original languageEnglish
Article numbere12606
Number of pages24
JournalParasite Immunology
Early online date24 Nov 2018
DOIs
Publication statusE-pub ahead of print - 24 Nov 2018

Keywords

  • zoonosis
  • congenital toxoplasmosis
  • immunopathogenesis
  • maternal-feal interface
  • activated-marcophage
  • pregnancy

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