How direct competition shapes coexistence and vaccine effects in multi-strain pathogen systems

Erida Gjini, Carina Valente, Raquel Sá-Leão, M. Gabriela M. Gomes

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


We describe an integrated modeling framework for understanding strain coexistence in polymorphic pathogen systems. Previous studies have debated the utility of neutral formulations and focused on cross-immunity between strains as a major stabilizing mechanism. Here we convey that direct competition for colonization mediates stable coexistence only when competitive abilities amongst pathogen clones satisfy certain pairwise asymmetries. We illustrate our ideas with nested SIS models of single and dual colonization, applied to polymorphic pneumococcal bacteria. By fitting the models to cross-sectional prevalence data from Portugal (before and after the introduction of a seven-valent pneumococcal conjugate vaccine), we are able to not only statistically compare neutral and non-neutral epidemiological formulations, but also estimate vaccine efficacy, transmission and competition parameters simultaneously. Our study highlights that the response of polymorphic pathogen populations to interventions holds crucial information about strain interactions, which can be extracted by suitable nested modeling.

Original languageEnglish
Pages (from-to)50-60
Number of pages11
JournalJournal of Theoretical Biology
Publication statusPublished - 7 Jan 2016


  • Bayesian inference
  • co-infection
  • ecology
  • neutral model
  • PCV7
  • pneumococcus


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