How can LVAD support influence ventricular energetics parameters in advanced heart failure patients? A retrospective study

Claudio De Lazzari, Massimo Capoccia, Silvia Marconi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background and objective: Here we present a retrospective analysis of six heart failure patients previously discussed at a multidisciplinary team meeting. Only three out of six patients underwent LVAD insertion as the most appropriate management option. Methods: We sought to reproduce the baseline conditions of these patients on hospital admission using our cardiovascular software simulator (CARDIOSIM ©). Subsequently, we simulated the effects of LVAD support and drug administration on left and right ventricular energetics parameters. LVAD assistance was delivered by CARDIOSIM ©based on the module reproducing the behaviour of the Berlin Heart INCOR pump. Results: The results of our simulations were in agreement with the multidisciplinary team meeting out- come. The analysis of ventricular energetics parameters based on external work and pressure volume area confirmed LVAD support as a beneficial therapeutic option for the three patients considered eligible for this type of treatment. The effects induced by LVAD support and drugs administration showed specific patterns between the two groups of patients. Conclusion: A quantitative approach with the ability to predict outcome during patient’s assessment may well be an aid and not a substitute for clinical decision-making.
Original languageEnglish
Pages (from-to)117-126
Number of pages10
JournalComputer Methods and Programs in Biomedicine
Volume172
Early online date23 Feb 2019
DOIs
Publication statusPublished - 30 Apr 2019

Fingerprint

Heart Failure
Retrospective Studies
Simulators
Software
Patient Outcome Assessment
Decision making
Pumps
Berlin
Pharmaceutical Preparations
Pressure
Therapeutics

Keywords

  • heart failure
  • external work
  • pressure volume are
  • software simulation
  • LVAD
  • milrinone

Cite this

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abstract = "Background and objective: Here we present a retrospective analysis of six heart failure patients previously discussed at a multidisciplinary team meeting. Only three out of six patients underwent LVAD insertion as the most appropriate management option. Methods: We sought to reproduce the baseline conditions of these patients on hospital admission using our cardiovascular software simulator (CARDIOSIM {\circledC}). Subsequently, we simulated the effects of LVAD support and drug administration on left and right ventricular energetics parameters. LVAD assistance was delivered by CARDIOSIM {\circledC}based on the module reproducing the behaviour of the Berlin Heart INCOR pump. Results: The results of our simulations were in agreement with the multidisciplinary team meeting out- come. The analysis of ventricular energetics parameters based on external work and pressure volume area confirmed LVAD support as a beneficial therapeutic option for the three patients considered eligible for this type of treatment. The effects induced by LVAD support and drugs administration showed specific patterns between the two groups of patients. Conclusion: A quantitative approach with the ability to predict outcome during patient’s assessment may well be an aid and not a substitute for clinical decision-making.",
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How can LVAD support influence ventricular energetics parameters in advanced heart failure patients? A retrospective study. / De Lazzari, Claudio; Capoccia, Massimo; Marconi, Silvia.

In: Computer Methods and Programs in Biomedicine, Vol. 172, 30.04.2019, p. 117-126.

Research output: Contribution to journalArticle

TY - JOUR

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