Hot-Melt-Extrusion (HME) is a flexible process that uses high temperature and pressure conditions to pump raw materials such as an Active Pharmaceutical Ingredient (API) and a pharmaceutical grade polymer through a barrel. The material is conveyed and mixed using intermeshing co-rotating twin-screws and then pushed through a die to form a well-shaped strand. Due to the high mixing degree provided by the twin-screws, the drug is transformed from crystalline to amorphous form. The use of twin-screw extruders is currently being implemented within continuous manufacturing platforms (Crowley, 2007).
|Number of pages||2|
|Publication status||Published - 7 Apr 2016|
|Event||PBP 10th World Meeting in Pharmaceutics, Biopharmeceutics and Pharmaceutical Technology - SECC, Glasgow, United Kingdom|
Duration: 4 Apr 2016 → 7 Apr 2016
|Conference||PBP 10th World Meeting in Pharmaceutics, Biopharmeceutics and Pharmaceutical Technology|
|Period||4/04/16 → 7/04/16|
- hot-melt extrusion
- pharmacurtical manufactures
- drug delivery
Martinez-Marcos, L., Lamprou, D., & Halbert, G. (2016). Hot-melt extrusion (HME) formulations of Albendazole for increasing dissolution properties. Poster session presented at PBP 10th World Meeting in Pharmaceutics, Biopharmeceutics and Pharmaceutical Technology, Glasgow, United Kingdom.