Hot-melt extrusion (HME) formulations of Albendazole for increasing dissolution properties

Laura Martinez-Marcos; Dimitrios Lamprou; Gavin Halbert

Hot-melt extrusion (HME) formulations of Albendazole for increasing dissolution properties

Laura Martinez-Marcos, Dimitrios Lamprou, Gavin Halbert

Research output: Contribution to conference › Poster › peer-review

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Abstract

Hot-Melt-Extrusion (HME) is a flexible process that uses high temperature and pressure conditions to pump raw materials such as an Active Pharmaceutical Ingredient (API) and a pharmaceutical grade polymer through a barrel. The material is conveyed and mixed using intermeshing co-rotating twin-screws and then pushed through a die to form a well-shaped strand. Due to the high mixing degree provided by the twin-screws, the drug is transformed from crystalline to amorphous form. The use of twin-screw extruders is currently being implemented within continuous manufacturing platforms (Crowley, 2007).

Original language	English
Number of pages	2
Publication status	Published - 7 Apr 2016
Event	PBP 10th World Meeting in Pharmaceutics, Biopharmeceutics and Pharmaceutical Technology - SECC, Glasgow, United Kingdom Duration: 4 Apr 2016 → 7 Apr 2016

Conference

Conference	PBP 10th World Meeting in Pharmaceutics, Biopharmeceutics and Pharmaceutical Technology
Country/Territory	United Kingdom
City	Glasgow
Period	4/04/16 → 7/04/16

Keywords

hot-melt extrusion
Albendazole
pharmacurtical manufactures
drug delivery

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Martinez-Marcos-etal-WMPBPT-2016-Hot-melt-extrusion-HME-formulations-of-albendazole-for-increasingAccepted author manuscript, 197 KB

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title = "Hot-melt extrusion (HME) formulations of Albendazole for increasing dissolution properties",

abstract = "Hot-Melt-Extrusion (HME) is a flexible process that uses high temperature and pressure conditions to pump raw materials such as an Active Pharmaceutical Ingredient (API) and a pharmaceutical grade polymer through a barrel. The material is conveyed and mixed using intermeshing co-rotating twin-screws and then pushed through a die to form a well-shaped strand. Due to the high mixing degree provided by the twin-screws, the drug is transformed from crystalline to amorphous form. The use of twin-screw extruders is currently being implemented within continuous manufacturing platforms (Crowley, 2007).",

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Hot-melt extrusion (HME) formulations of Albendazole for increasing dissolution properties. / Martinez-Marcos, Laura; Lamprou, Dimitrios; Halbert, Gavin.
2016. Poster session presented at PBP 10th World Meeting in Pharmaceutics, Biopharmeceutics and Pharmaceutical Technology, Glasgow, United Kingdom.

Research output: Contribution to conference › Poster › peer-review

TY - CONF

T1 - Hot-melt extrusion (HME) formulations of Albendazole for increasing dissolution properties

AU - Martinez-Marcos, Laura

AU - Lamprou, Dimitrios

AU - Halbert, Gavin

PY - 2016/4/7

Y1 - 2016/4/7

N2 - Hot-Melt-Extrusion (HME) is a flexible process that uses high temperature and pressure conditions to pump raw materials such as an Active Pharmaceutical Ingredient (API) and a pharmaceutical grade polymer through a barrel. The material is conveyed and mixed using intermeshing co-rotating twin-screws and then pushed through a die to form a well-shaped strand. Due to the high mixing degree provided by the twin-screws, the drug is transformed from crystalline to amorphous form. The use of twin-screw extruders is currently being implemented within continuous manufacturing platforms (Crowley, 2007).

AB - Hot-Melt-Extrusion (HME) is a flexible process that uses high temperature and pressure conditions to pump raw materials such as an Active Pharmaceutical Ingredient (API) and a pharmaceutical grade polymer through a barrel. The material is conveyed and mixed using intermeshing co-rotating twin-screws and then pushed through a die to form a well-shaped strand. Due to the high mixing degree provided by the twin-screws, the drug is transformed from crystalline to amorphous form. The use of twin-screw extruders is currently being implemented within continuous manufacturing platforms (Crowley, 2007).

KW - hot-melt extrusion

KW - Albendazole

KW - pharmacurtical manufactures

KW - drug delivery

UR - https://www.apgi.org/10th-world-meeting-on-pharmaceutics-biopharmaceutics-and-pharmaceutical-technology/

M3 - Poster

T2 - PBP 10th World Meeting in Pharmaceutics, Biopharmeceutics and Pharmaceutical Technology

Y2 - 4 April 2016 through 7 April 2016

ER -

Hot-melt extrusion (HME) formulations of Albendazole for increasing dissolution properties

Abstract

Conference

Keywords

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