Hot-melt extrusion (HME) formulations of Albendazole for increasing dissolution properties

Laura Martinez-Marcos, Dimitrios Lamprou, Gavin Halbert

Research output: Contribution to conferencePoster

47 Downloads (Pure)

Abstract

Hot-Melt-Extrusion (HME) is a flexible process that uses high temperature and pressure conditions to pump raw materials such as an Active Pharmaceutical Ingredient (API) and a pharmaceutical grade polymer through a barrel. The material is conveyed and mixed using intermeshing co-rotating twin-screws and then pushed through a die to form a well-shaped strand. Due to the high mixing degree provided by the twin-screws, the drug is transformed from crystalline to amorphous form. The use of twin-screw extruders is currently being implemented within continuous manufacturing platforms (Crowley, 2007).
Original languageEnglish
Number of pages2
Publication statusPublished - 7 Apr 2016
EventPBP 10th World Meeting in Pharmaceutics, Biopharmeceutics and Pharmaceutical Technology - SECC, Glasgow, United Kingdom
Duration: 4 Apr 20167 Apr 2016

Conference

ConferencePBP 10th World Meeting in Pharmaceutics, Biopharmeceutics and Pharmaceutical Technology
CountryUnited Kingdom
CityGlasgow
Period4/04/167/04/16

Keywords

  • hot-melt extrusion
  • Albendazole
  • pharmacurtical manufactures
  • drug delivery

Cite this

Martinez-Marcos, L., Lamprou, D., & Halbert, G. (2016). Hot-melt extrusion (HME) formulations of Albendazole for increasing dissolution properties. Poster session presented at PBP 10th World Meeting in Pharmaceutics, Biopharmeceutics and Pharmaceutical Technology, Glasgow, United Kingdom.