Abstract
Sleep is an essential ubiquitous biological process, a periodical state of quiescence in which there is minimal processing of sensory information and no interaction with conspecifics or the environment. Despite relevant research on sleep structure and testing of numerous endogenous sleep-affecting chemicals, questions as to the precise mechanisms and functions of sleep remain without satisfactory responses. The purpose of this review is to report on current evidence as regards the effect of several endogenous and exogenous hormones, hormonal agents, and neuropeptides on sleep onset or wake process, when administered in humans in specific doses and via different routes. The actions of several peptides are presented in detail. Some of them (growth hormone releasing hormone, ghrelin, galanin, neuropeptide Y) seem to promote sleep, whereas others (corticotropin, somatostatin) impair its continuity.
| Language | English |
|---|---|
| Pages | 232-248 |
| Number of pages | 17 |
| Journal | Hormones |
| Volume | 8 |
| Issue number | 4 |
| Publication status | Published - 31 Oct 2009 |
| Externally published | Yes |
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Keywords
- Ghrelin
- GHRH
- hormones
- melatonin
- neuroendocrine regulation
- neuropeptides
- NPY
- sleep
- sleep disorders
- wakefulness
Cite this
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Hormones, hormonal agents, and neuropeptides involved in the neuroendocrine regulation of sleep in humans. / Kotronoulas, Grigorios; Stamatakis, Antonios; Stylianopoulou, Fotini.
In: Hormones, Vol. 8, No. 4, 31.10.2009, p. 232-248.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Hormones, hormonal agents, and neuropeptides involved in the neuroendocrine regulation of sleep in humans
AU - Kotronoulas, Grigorios
AU - Stamatakis, Antonios
AU - Stylianopoulou, Fotini
PY - 2009/10/31
Y1 - 2009/10/31
N2 - Sleep is an essential ubiquitous biological process, a periodical state of quiescence in which there is minimal processing of sensory information and no interaction with conspecifics or the environment. Despite relevant research on sleep structure and testing of numerous endogenous sleep-affecting chemicals, questions as to the precise mechanisms and functions of sleep remain without satisfactory responses. The purpose of this review is to report on current evidence as regards the effect of several endogenous and exogenous hormones, hormonal agents, and neuropeptides on sleep onset or wake process, when administered in humans in specific doses and via different routes. The actions of several peptides are presented in detail. Some of them (growth hormone releasing hormone, ghrelin, galanin, neuropeptide Y) seem to promote sleep, whereas others (corticotropin, somatostatin) impair its continuity.
AB - Sleep is an essential ubiquitous biological process, a periodical state of quiescence in which there is minimal processing of sensory information and no interaction with conspecifics or the environment. Despite relevant research on sleep structure and testing of numerous endogenous sleep-affecting chemicals, questions as to the precise mechanisms and functions of sleep remain without satisfactory responses. The purpose of this review is to report on current evidence as regards the effect of several endogenous and exogenous hormones, hormonal agents, and neuropeptides on sleep onset or wake process, when administered in humans in specific doses and via different routes. The actions of several peptides are presented in detail. Some of them (growth hormone releasing hormone, ghrelin, galanin, neuropeptide Y) seem to promote sleep, whereas others (corticotropin, somatostatin) impair its continuity.
KW - Ghrelin
KW - GHRH
KW - hormones
KW - melatonin
KW - neuroendocrine regulation
KW - neuropeptides
KW - NPY
KW - sleep
KW - sleep disorders
KW - wakefulness
UR - http://www.scopus.com/inward/record.url?scp=74849086579&partnerID=8YFLogxK
M3 - Review article
VL - 8
SP - 232
EP - 248
JO - Hormones
T2 - Hormones
JF - Hormones
SN - 1109-3099
IS - 4
ER -