Hormones, hormonal agents, and neuropeptides involved in the neuroendocrine regulation of sleep in humans

Grigorios Kotronoulas, Antonios Stamatakis, Fotini Stylianopoulou

Research output: Contribution to journalReview article

26 Citations (Scopus)

Abstract

Sleep is an essential ubiquitous biological process, a periodical state of quiescence in which there is minimal processing of sensory information and no interaction with conspecifics or the environment. Despite relevant research on sleep structure and testing of numerous endogenous sleep-affecting chemicals, questions as to the precise mechanisms and functions of sleep remain without satisfactory responses. The purpose of this review is to report on current evidence as regards the effect of several endogenous and exogenous hormones, hormonal agents, and neuropeptides on sleep onset or wake process, when administered in humans in specific doses and via different routes. The actions of several peptides are presented in detail. Some of them (growth hormone releasing hormone, ghrelin, galanin, neuropeptide Y) seem to promote sleep, whereas others (corticotropin, somatostatin) impair its continuity.

LanguageEnglish
Pages232-248
Number of pages17
JournalHormones
Volume8
Issue number4
Publication statusPublished - 31 Oct 2009
Externally publishedYes

Fingerprint

Neuropeptides
Sleep
Hormones
Biological Phenomena
Galanin
Growth Hormone-Releasing Hormone
Ghrelin
Neuropeptide Y
Somatostatin
Automatic Data Processing
Adrenocorticotropic Hormone
Peptides
Research

Keywords

  • Ghrelin
  • GHRH
  • hormones
  • melatonin
  • neuroendocrine regulation
  • neuropeptides
  • NPY
  • sleep
  • sleep disorders
  • wakefulness

Cite this

Kotronoulas, G., Stamatakis, A., & Stylianopoulou, F. (2009). Hormones, hormonal agents, and neuropeptides involved in the neuroendocrine regulation of sleep in humans. Hormones, 8(4), 232-248.
Kotronoulas, Grigorios ; Stamatakis, Antonios ; Stylianopoulou, Fotini. / Hormones, hormonal agents, and neuropeptides involved in the neuroendocrine regulation of sleep in humans. In: Hormones. 2009 ; Vol. 8, No. 4. pp. 232-248.
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Kotronoulas, G, Stamatakis, A & Stylianopoulou, F 2009, 'Hormones, hormonal agents, and neuropeptides involved in the neuroendocrine regulation of sleep in humans' Hormones, vol. 8, no. 4, pp. 232-248.

Hormones, hormonal agents, and neuropeptides involved in the neuroendocrine regulation of sleep in humans. / Kotronoulas, Grigorios; Stamatakis, Antonios; Stylianopoulou, Fotini.

In: Hormones, Vol. 8, No. 4, 31.10.2009, p. 232-248.

Research output: Contribution to journalReview article

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Kotronoulas G, Stamatakis A, Stylianopoulou F. Hormones, hormonal agents, and neuropeptides involved in the neuroendocrine regulation of sleep in humans. Hormones. 2009 Oct 31;8(4):232-248.