Highly efficient reduction of unactivated aryl and alkyl iodides by a ground-state neutral organic electron donor

J.A. Murphy; T.A. Khan; S. Zhou; M. Mohan; D.W. Thomson

doi:10.1002/anie.200462038

Highly efficient reduction of unactivated aryl and alkyl iodides by a ground-state neutral organic electron donor

J.A. Murphy, T.A. Khan, S. Zhou, M. Mohan, D.W. Thomson

Pure And Applied Chemistry

Research output: Contribution to journal › Article › peer-review

137 Citations (Scopus)

Abstract

Electron-transfer reductions of unactivated aryl and alkyl iodides with a neutral ground-state organic molecule are reported. The reducing agent 1 is formed in two steps from N-methylbenzimidazole using very simple chemistry, and subsequent treatment of the iodoalkane or -arene with 1 affords cyclized products (see scheme).

Original language	English
Pages (from-to)	1356-1360
Number of pages	5
Journal	Angewandte Chemie
Volume	44
Issue number	9
DOIs	https://doi.org/10.1002/anie.200462038
Publication status	Published - 2005

Keywords

cyclization
synthetic methods
reduction
radical reactions
electron transfer

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10.1002/anie.200462038

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abstract = "Electron-transfer reductions of unactivated aryl and alkyl iodides with a neutral ground-state organic molecule are reported. The reducing agent 1 is formed in two steps from N-methylbenzimidazole using very simple chemistry, and subsequent treatment of the iodoalkane or -arene with 1 affords cyclized products (see scheme). ",

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author = "J.A. Murphy and T.A. Khan and S. Zhou and M. Mohan and D.W. Thomson",

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AU - Murphy, J.A.

AU - Khan, T.A.

AU - Zhou, S.

AU - Mohan, M.

AU - Thomson, D.W.

N1 - PV: 21365

PY - 2005

Y1 - 2005

N2 - Electron-transfer reductions of unactivated aryl and alkyl iodides with a neutral ground-state organic molecule are reported. The reducing agent 1 is formed in two steps from N-methylbenzimidazole using very simple chemistry, and subsequent treatment of the iodoalkane or -arene with 1 affords cyclized products (see scheme).

AB - Electron-transfer reductions of unactivated aryl and alkyl iodides with a neutral ground-state organic molecule are reported. The reducing agent 1 is formed in two steps from N-methylbenzimidazole using very simple chemistry, and subsequent treatment of the iodoalkane or -arene with 1 affords cyclized products (see scheme).

KW - cyclization

KW - synthetic methods

KW - reduction

KW - radical reactions

KW - electron transfer

UR - http://dx.doi.org/10.1002/anie.200462038

U2 - 10.1002/anie.200462038

DO - 10.1002/anie.200462038

M3 - Article

SN - 1521-3773

VL - 44

SP - 1356

EP - 1360

JO - Angewandte Chemie

JF - Angewandte Chemie

IS - 9

ER -

Highly efficient reduction of unactivated aryl and alkyl iodides by a ground-state neutral organic electron donor

Abstract

Keywords

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