Highly efficient reduction of unactivated aryl and alkyl iodides by a ground-state neutral organic electron donor

J.A. Murphy, T.A. Khan, S. Zhou, M. Mohan, D.W. Thomson

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Electron-transfer reductions of unactivated aryl and alkyl iodides with a neutral ground-state organic molecule are reported. The reducing agent 1 is formed in two steps from N-methylbenzimidazole using very simple chemistry, and subsequent treatment of the iodoalkane or -arene with 1 affords cyclized products (see scheme).

LanguageEnglish
Pages1356-1360
Number of pages5
JournalAngewandte Chemie
Volume44
Issue number9
DOIs
Publication statusPublished - 2005

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Reducing Agents
Iodides
Reducing agents
Ground state
Electrons
Molecules

Keywords

  • cyclization
  • synthetic methods
  • reduction
  • radical reactions
  • electron transfer

Cite this

Murphy, J.A. ; Khan, T.A. ; Zhou, S. ; Mohan, M. ; Thomson, D.W. / Highly efficient reduction of unactivated aryl and alkyl iodides by a ground-state neutral organic electron donor. In: Angewandte Chemie. 2005 ; Vol. 44, No. 9. pp. 1356-1360.
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Highly efficient reduction of unactivated aryl and alkyl iodides by a ground-state neutral organic electron donor. / Murphy, J.A.; Khan, T.A.; Zhou, S.; Mohan, M.; Thomson, D.W.

In: Angewandte Chemie, Vol. 44, No. 9, 2005, p. 1356-1360.

Research output: Contribution to journalArticle

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AU - Khan, T.A.

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AU - Mohan, M.

AU - Thomson, D.W.

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AB - Electron-transfer reductions of unactivated aryl and alkyl iodides with a neutral ground-state organic molecule are reported. The reducing agent 1 is formed in two steps from N-methylbenzimidazole using very simple chemistry, and subsequent treatment of the iodoalkane or -arene with 1 affords cyclized products (see scheme).

KW - cyclization

KW - synthetic methods

KW - reduction

KW - radical reactions

KW - electron transfer

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