Electron-transfer reductions of unactivated aryl and alkyl iodides with a neutral ground-state organic molecule are reported. The reducing agent 1 is formed in two steps from N-methylbenzimidazole using very simple chemistry, and subsequent treatment of the iodoalkane or -arene with 1 affords cyclized products (see scheme).
- synthetic methods
- radical reactions
- electron transfer
Murphy, J. A., Khan, T. A., Zhou, S., Mohan, M., & Thomson, D. W. (2005). Highly efficient reduction of unactivated aryl and alkyl iodides by a ground-state neutral organic electron donor. Angewandte Chemie, 44(9), 1356-1360. https://doi.org/10.1002/anie.200462038