Highly active iridium(I) complexes for novel beta-selective hydrogen isotope exchange processes

William Kerr, Richard J. Mudd

Research output: Contribution to journalMeeting abstract

Abstract

In recent years, research within the Kerr group has lead to the development of a series of highly active cationic iridium(I) complexes bearing a combination of bulky phosphine/NHC ligands 1. These complexes can facilitate mild and selective ortho-hydrogen isotope exchange (HIE)with a wide variety of functional handles. Additionally, they perform excellently in olefin hydrogenation processes, furnishing excellent yields under mild reaction conditions. Ongoing research continues to further explain and optimise the efficacy of these complexes, with the aim of developing a series of catalysts that can meet the escalating demands of any HIE or hydrogenation process.Through this research, we have discovered that it is possible to use an unsaturated species, such as 2, bearing a suitable functional handle, and incorporate selectively a hydrogen isotope at the β-position with high levels of incorporation 3 (Scheme 1). The full details of our research in this novel area of hydrogen isotope exchange will be discussed as part of this poster presentation.

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Iridium
Isotopes
Hydrogen
Bearings (structural)
phosphine
Hydrogenation
Research
Posters
Alkenes
Ligands
Catalysts

Keywords

  • cationic iridium(I) complexes
  • isotope exchange
  • olefin hydrogenation

Cite this

@article{789d4363fa854dcd989c9b5845b34015,
title = "Highly active iridium(I) complexes for novel beta-selective hydrogen isotope exchange processes",
abstract = "In recent years, research within the Kerr group has lead to the development of a series of highly active cationic iridium(I) complexes bearing a combination of bulky phosphine/NHC ligands 1. These complexes can facilitate mild and selective ortho-hydrogen isotope exchange (HIE)with a wide variety of functional handles. Additionally, they perform excellently in olefin hydrogenation processes, furnishing excellent yields under mild reaction conditions. Ongoing research continues to further explain and optimise the efficacy of these complexes, with the aim of developing a series of catalysts that can meet the escalating demands of any HIE or hydrogenation process.Through this research, we have discovered that it is possible to use an unsaturated species, such as 2, bearing a suitable functional handle, and incorporate selectively a hydrogen isotope at the β-position with high levels of incorporation 3 (Scheme 1). The full details of our research in this novel area of hydrogen isotope exchange will be discussed as part of this poster presentation.",
keywords = "cationic iridium(I) complexes, isotope exchange, olefin hydrogenation",
author = "William Kerr and Mudd, {Richard J.}",
year = "2014",
month = "3",
day = "1",
doi = "10.1002/jlcr.3173",
language = "English",
volume = "57",
pages = "185--186",
journal = "Journal of Labelled Compounds and Radiopharmaceuticals",
issn = "0362-4803",
number = "3",

}

Highly active iridium(I) complexes for novel beta-selective hydrogen isotope exchange processes. / Kerr, William; Mudd, Richard J.

In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 57, No. 3, 01.03.2014, p. 185-186.

Research output: Contribution to journalMeeting abstract

TY - JOUR

T1 - Highly active iridium(I) complexes for novel beta-selective hydrogen isotope exchange processes

AU - Kerr, William

AU - Mudd, Richard J.

PY - 2014/3/1

Y1 - 2014/3/1

N2 - In recent years, research within the Kerr group has lead to the development of a series of highly active cationic iridium(I) complexes bearing a combination of bulky phosphine/NHC ligands 1. These complexes can facilitate mild and selective ortho-hydrogen isotope exchange (HIE)with a wide variety of functional handles. Additionally, they perform excellently in olefin hydrogenation processes, furnishing excellent yields under mild reaction conditions. Ongoing research continues to further explain and optimise the efficacy of these complexes, with the aim of developing a series of catalysts that can meet the escalating demands of any HIE or hydrogenation process.Through this research, we have discovered that it is possible to use an unsaturated species, such as 2, bearing a suitable functional handle, and incorporate selectively a hydrogen isotope at the β-position with high levels of incorporation 3 (Scheme 1). The full details of our research in this novel area of hydrogen isotope exchange will be discussed as part of this poster presentation.

AB - In recent years, research within the Kerr group has lead to the development of a series of highly active cationic iridium(I) complexes bearing a combination of bulky phosphine/NHC ligands 1. These complexes can facilitate mild and selective ortho-hydrogen isotope exchange (HIE)with a wide variety of functional handles. Additionally, they perform excellently in olefin hydrogenation processes, furnishing excellent yields under mild reaction conditions. Ongoing research continues to further explain and optimise the efficacy of these complexes, with the aim of developing a series of catalysts that can meet the escalating demands of any HIE or hydrogenation process.Through this research, we have discovered that it is possible to use an unsaturated species, such as 2, bearing a suitable functional handle, and incorporate selectively a hydrogen isotope at the β-position with high levels of incorporation 3 (Scheme 1). The full details of our research in this novel area of hydrogen isotope exchange will be discussed as part of this poster presentation.

KW - cationic iridium(I) complexes

KW - isotope exchange

KW - olefin hydrogenation

UR - http://onlinelibrary.wiley.com/doi/10.1002/jlcr.3173/abstract

U2 - 10.1002/jlcr.3173

DO - 10.1002/jlcr.3173

M3 - Meeting abstract

VL - 57

SP - 185

EP - 186

JO - Journal of Labelled Compounds and Radiopharmaceuticals

T2 - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

SN - 0362-4803

IS - 3

ER -