High throughput surface characterization: a review of a new tool for screening prospective biomedical material arrays

Martyn C. Davies, Morgan R. Alexander, Andrew L. Hook, Jing Yang, Ying Mei, Michael Taylor, Andrew J. Urquhart, Robert Langer, Daniel G. Anderson

Research output: Contribution to journalLiterature review

30 Citations (Scopus)

Abstract

The application of high throughput surface characterization (HTSC) to the analysis of polymeric biomaterial libraries is an important advancement for the discovery and development of new biomedical materials and is the focus of this review. The potential for HTSC to identify structure/activity relationships for large libraries of materials can be utilized to accelerate materials discovery as well as providing insight into the underlying biological-material interactions. Furthermore, the correlations identified between surface chemical structure and cellular behavior could not have been predicted by a rational design approach based simply on review of bulk structure, which demonstrates the importance of HTSC in the assessment of cell-material and cell-biomolecular interactions that are dependent on surface properties.

Original languageEnglish
Pages (from-to)741-751
Number of pages11
JournalJournal of Drug Targeting
Volume18
Issue number10
DOIs
Publication statusPublished - Dec 2010

Keywords

  • Polymer
  • copolymer
  • high throughput drug screening
  • mathematical model
  • stem cell
  • secondary ion mass spectrometry
  • water contact angle
  • multivariate statistics
  • embryonic stem-cells
  • microarrays
  • combinatorial
  • biomaterials
  • fabrication
  • polymers
  • growth
  • chemistry
  • adhesion

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