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High-throughput electrochemistry: state of the art, challenges, and perspective

Alfie G. Wills, Sylvain Charvet, Claudio Battilocchio, Christopher C. Scarborough, Katherine M. P. Wheelhouse, Darren L. Poole, Nessa Carson, Julien C. Vantourout

Research output: Contribution to journalReview articlepeer-review

Abstract

Electrochemical transformations involve complex parameter interactions, ranging from universal chemistry variables such as solvent and reagents to specialist factors including electrode material and current density. Hence, the development of a robust and scale-independent electrochemical reaction can currently be a challenge. High-throughput experimentation (HTE) is an enabling method for reaction optimization and robustness testing. Here we provide an industrial and academic perspective on the state of the art of the combination of HTE with electrochemical reaction optimization for applications, including scale-up. We then present our vision for a future in which HTE reduces barriers to wide adoption of electrochemistry across the field of chemical synthesis.
Original languageEnglish
Pages (from-to)2587-2600
Number of pages14
JournalOrganic Process Research and Development
Volume25
Issue number12
Early online date3 Aug 2021
DOIs
Publication statusPublished - 17 Dec 2021

Funding

Financial support for this work was provided by the CNRS, French Ministry of Research, and the University of Lyon I. A.G.W. thanks the GlaxoSmithKline/University of Strathclyde Collaborative Ph.D. program and the EPSRC for funding via Prosperity Partnership EP/S035990/1. S.C. thanks the ICBMS for a Master’s fellowship.

Keywords

  • electrochemistry
  • high-throughput
  • technology acceptance
  • method development

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