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The pharmaceutical material chlorothiazide (6-chloro-4H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide) has been studied under high-pressure conditions using single-crystal and powder X-ray diffraction. An isosymmetric phase transition to a second polymorph occurs at 4.4 GPa. An analysis of the structural changes that occur during this phase transition has been performed.
- 4-benzothiadiazine-7-sulfonamide 1
- single-crystal diffraction
- powder X-ray diffraction
- isosymmetric phase transition
- structural change