High-pressure structural studies of the pharmaceutical, chlorothiazide

I.D.H. Oswald, Alistair R. Lennie, C.R. Pulham, K. Shankland

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The pharmaceutical material chlorothiazide (6-chloro-4H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide) has been studied under high-pressure conditions using single-crystal and powder X-ray diffraction. An isosymmetric phase transition to a second polymorph occurs at 4.4 GPa. An analysis of the structural changes that occur during this phase transition has been performed.
Original languageEnglish
Pages (from-to)2533-2540
Number of pages7
JournalCrystEngComm
Volume12
Issue number9
DOIs
Publication statusPublished - 2010

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Keywords

  • chlorothiazide
  • 6-chloro-4H-1
  • 2
  • 4-benzothiadiazine-7-sulfonamide 1
  • 1-dioxide
  • high-pressure
  • single-crystal diffraction
  • powder X-ray diffraction
  • isosymmetric phase transition
  • polymorph
  • structural change

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