Projects per year
Abstract
The pharmaceutical material chlorothiazide (6-chloro-4H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide) has been studied under high-pressure conditions using single-crystal and powder X-ray diffraction. An isosymmetric phase transition to a second polymorph occurs at 4.4 GPa. An analysis of the structural changes that occur during this phase transition has been performed.
| Original language | English |
|---|---|
| Pages (from-to) | 2533-2540 |
| Number of pages | 7 |
| Journal | CrystEngComm |
| Volume | 12 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2010 |
Keywords
- chlorothiazide
- 6-chloro-4H-1
- 2
- 4-benzothiadiazine-7-sulfonamide 1
- 1-dioxide
- high-pressure
- single-crystal diffraction
- powder X-ray diffraction
- isosymmetric phase transition
- polymorph
- structural change
Fingerprint
Dive into the research topics of 'High-pressure structural studies of the pharmaceutical, chlorothiazide'. Together they form a unique fingerprint.Projects
- 1 Finished
-
Physical Organic Chemistry: Opportunities In Synthesis, Materials And Pharmaceuticals (Science And Innovation Award)
Murphy, J. (Principal Investigator), Coombs, G. (Co-investigator), Ferguson, A. (Co-investigator) & Florence, A. (Co-investigator)
Scottish Funding Council SFC, EPSRC (Engineering and Physical Sciences Research Council)
1/09/07 → 30/10/12
Project: Research
Activities
- 1 Participation in conference
-
British Crystallographic Association Meeting
Oswald, I. (Invited speaker)
14 Apr 2011Activity: Participating in or organising an event types › Participation in conference