High power laser production of short-lived isotopes for positron emission tomography

K.W.D. Ledingham, P. McKenna, T. McCanny, S. Shimizu, J.M. Yang, L. Robson, J. Zweit, J.M. Gillies, J. Bailey, G.N. Chimon, R.J. Clarke, D. Neely, P.A. Norreys, J.L. Collier, R.P. Singhal, M.S. Wei, S.P.D. Mangles, P. Nilson, K. Krushelnick, M. Zepf

Research output: Contribution to journalArticle

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Abstract

Positron emission tomography (PET) is a powerful diagnostic/imaging technique requiring the production of the short-lived positron emitting isotopes 11C, 13N, 15O and 18F by proton irradiation of natural/enriched targets using cyclotrons. The development of PET has been hampered due to the size and shielding requirements of nuclear installations. Recent results show that when an intense laser beam interacts with solid targets, megaelectronvolt (MeV) protons capable of producing PET isotopes are generated. This report describes how to generate intense PET sources of 11C and 18F using a petawatt laser beam. The work describing the laser production of 18F through a (p,n) 18O reaction, and the subsequent synthesis of 2-[18F] is reported for the first time. The potential for developing compact laser technology for this purpose is discussed.
LanguageEnglish
Pages2341-2345
Number of pages4
JournalJournal of Physics D: Applied Physics
Volume37
Issue number16
DOIs
Publication statusPublished - 21 Aug 2004

Fingerprint

Positron emission tomography
High power lasers
Isotopes
high power lasers
positrons
isotopes
tomography
Laser beams
Proton irradiation
Lasers
laser beams
Cyclotrons
Positrons
proton irradiation
Shielding
Protons
imaging techniques
installing
lasers
cyclotrons

Keywords

  • positron emission tomography
  • lasers
  • isotopes

Cite this

Ledingham, K.W.D. ; McKenna, P. ; McCanny, T. ; Shimizu, S. ; Yang, J.M. ; Robson, L. ; Zweit, J. ; Gillies, J.M. ; Bailey, J. ; Chimon, G.N. ; Clarke, R.J. ; Neely, D. ; Norreys, P.A. ; Collier, J.L. ; Singhal, R.P. ; Wei, M.S. ; Mangles, S.P.D. ; Nilson, P. ; Krushelnick, K. ; Zepf, M. / High power laser production of short-lived isotopes for positron emission tomography. In: Journal of Physics D: Applied Physics. 2004 ; Vol. 37, No. 16. pp. 2341-2345.
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abstract = "Positron emission tomography (PET) is a powerful diagnostic/imaging technique requiring the production of the short-lived positron emitting isotopes 11C, 13N, 15O and 18F by proton irradiation of natural/enriched targets using cyclotrons. The development of PET has been hampered due to the size and shielding requirements of nuclear installations. Recent results show that when an intense laser beam interacts with solid targets, megaelectronvolt (MeV) protons capable of producing PET isotopes are generated. This report describes how to generate intense PET sources of 11C and 18F using a petawatt laser beam. The work describing the laser production of 18F through a (p,n) 18O reaction, and the subsequent synthesis of 2-[18F] is reported for the first time. The potential for developing compact laser technology for this purpose is discussed.",
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Ledingham, KWD, McKenna, P, McCanny, T, Shimizu, S, Yang, JM, Robson, L, Zweit, J, Gillies, JM, Bailey, J, Chimon, GN, Clarke, RJ, Neely, D, Norreys, PA, Collier, JL, Singhal, RP, Wei, MS, Mangles, SPD, Nilson, P, Krushelnick, K & Zepf, M 2004, 'High power laser production of short-lived isotopes for positron emission tomography' Journal of Physics D: Applied Physics, vol. 37, no. 16, pp. 2341-2345. https://doi.org/10.1088/0022-3727/37/16/019

High power laser production of short-lived isotopes for positron emission tomography. / Ledingham, K.W.D.; McKenna, P.; McCanny, T.; Shimizu, S.; Yang, J.M.; Robson, L.; Zweit, J.; Gillies, J.M.; Bailey, J.; Chimon, G.N.; Clarke, R.J.; Neely, D.; Norreys, P.A.; Collier, J.L.; Singhal, R.P.; Wei, M.S.; Mangles, S.P.D.; Nilson, P.; Krushelnick, K.; Zepf, M.

In: Journal of Physics D: Applied Physics, Vol. 37, No. 16, 21.08.2004, p. 2341-2345.

Research output: Contribution to journalArticle

TY - JOUR

T1 - High power laser production of short-lived isotopes for positron emission tomography

AU - Ledingham, K.W.D.

AU - McKenna, P.

AU - McCanny, T.

AU - Shimizu, S.

AU - Yang, J.M.

AU - Robson, L.

AU - Zweit, J.

AU - Gillies, J.M.

AU - Bailey, J.

AU - Chimon, G.N.

AU - Clarke, R.J.

AU - Neely, D.

AU - Norreys, P.A.

AU - Collier, J.L.

AU - Singhal, R.P.

AU - Wei, M.S.

AU - Mangles, S.P.D.

AU - Nilson, P.

AU - Krushelnick, K.

AU - Zepf, M.

PY - 2004/8/21

Y1 - 2004/8/21

N2 - Positron emission tomography (PET) is a powerful diagnostic/imaging technique requiring the production of the short-lived positron emitting isotopes 11C, 13N, 15O and 18F by proton irradiation of natural/enriched targets using cyclotrons. The development of PET has been hampered due to the size and shielding requirements of nuclear installations. Recent results show that when an intense laser beam interacts with solid targets, megaelectronvolt (MeV) protons capable of producing PET isotopes are generated. This report describes how to generate intense PET sources of 11C and 18F using a petawatt laser beam. The work describing the laser production of 18F through a (p,n) 18O reaction, and the subsequent synthesis of 2-[18F] is reported for the first time. The potential for developing compact laser technology for this purpose is discussed.

AB - Positron emission tomography (PET) is a powerful diagnostic/imaging technique requiring the production of the short-lived positron emitting isotopes 11C, 13N, 15O and 18F by proton irradiation of natural/enriched targets using cyclotrons. The development of PET has been hampered due to the size and shielding requirements of nuclear installations. Recent results show that when an intense laser beam interacts with solid targets, megaelectronvolt (MeV) protons capable of producing PET isotopes are generated. This report describes how to generate intense PET sources of 11C and 18F using a petawatt laser beam. The work describing the laser production of 18F through a (p,n) 18O reaction, and the subsequent synthesis of 2-[18F] is reported for the first time. The potential for developing compact laser technology for this purpose is discussed.

KW - positron emission tomography

KW - lasers

KW - isotopes

UR - http://dx.doi.org/10.1088/0022-3727/37/16/019

U2 - 10.1088/0022-3727/37/16/019

DO - 10.1088/0022-3727/37/16/019

M3 - Article

VL - 37

SP - 2341

EP - 2345

JO - Journal of Physics D: Applied Physics

T2 - Journal of Physics D: Applied Physics

JF - Journal of Physics D: Applied Physics

SN - 0022-3727

IS - 16

ER -