High power laser production of short-lived isotopes for positron emission tomography

K.W.D. Ledingham; P. McKenna; T. McCanny; S. Shimizu; J.M. Yang; L. Robson; J. Zweit; J.M. Gillies; J. Bailey; G.N. Chimon; R.J. Clarke; D. Neely; P.A. Norreys; J.L. Collier; R.P. Singhal; M.S. Wei; S.P.D. Mangles; P. Nilson; K. Krushelnick; M. Zepf

doi:10.1088/0022-3727/37/16/019

High power laser production of short-lived isotopes for positron emission tomography

K.W.D. Ledingham, P. McKenna, T. McCanny, S. Shimizu, J.M. Yang, L. Robson, J. Zweit, J.M. Gillies, J. Bailey, G.N. Chimon, R.J. Clarke, D. Neely, P.A. Norreys, J.L. Collier, R.P. Singhal, M.S. Wei, S.P.D. Mangles, P. Nilson, K. Krushelnick, M. Zepf

Research output: Contribution to journal › Article › peer-review

111 Citations (Scopus)

Abstract

Positron emission tomography (PET) is a powerful diagnostic/imaging technique requiring the production of the short-lived positron emitting isotopes 11C, 13N, 15O and 18F by proton irradiation of natural/enriched targets using cyclotrons. The development of PET has been hampered due to the size and shielding requirements of nuclear installations. Recent results show that when an intense laser beam interacts with solid targets, megaelectronvolt (MeV) protons capable of producing PET isotopes are generated. This report describes how to generate intense PET sources of 11C and 18F using a petawatt laser beam. The work describing the laser production of 18F through a (p,n) 18O reaction, and the subsequent synthesis of 2-[18F] is reported for the first time. The potential for developing compact laser technology for this purpose is discussed.

Original language	English
Pages (from-to)	2341-2345
Number of pages	4
Journal	Journal of Physics D: Applied Physics
Volume	37
Issue number	16
DOIs	https://doi.org/10.1088/0022-3727/37/16/019
Publication status	Published - 21 Aug 2004

Keywords

positron emission tomography
lasers
isotopes

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Ledingham, K. W. D., McKenna, P., McCanny, T., Shimizu, S., Yang, J. M., Robson, L., Zweit, J., Gillies, J. M., Bailey, J., Chimon, G. N., Clarke, R. J., Neely, D., Norreys, P. A., Collier, J. L., Singhal, R. P., Wei, M. S., Mangles, S. P. D., Nilson, P., Krushelnick, K., & Zepf, M. (2004). High power laser production of short-lived isotopes for positron emission tomography. Journal of Physics D: Applied Physics, 37(16), 2341-2345. https://doi.org/10.1088/0022-3727/37/16/019

Ledingham, K.W.D. ; McKenna, P. ; McCanny, T. ; Shimizu, S. ; Yang, J.M. ; Robson, L. ; Zweit, J. ; Gillies, J.M. ; Bailey, J. ; Chimon, G.N. ; Clarke, R.J. ; Neely, D. ; Norreys, P.A. ; Collier, J.L. ; Singhal, R.P. ; Wei, M.S. ; Mangles, S.P.D. ; Nilson, P. ; Krushelnick, K. ; Zepf, M. / High power laser production of short-lived isotopes for positron emission tomography. In: Journal of Physics D: Applied Physics. 2004 ; Vol. 37, No. 16. pp. 2341-2345.

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title = "High power laser production of short-lived isotopes for positron emission tomography",

abstract = "Positron emission tomography (PET) is a powerful diagnostic/imaging technique requiring the production of the short-lived positron emitting isotopes 11C, 13N, 15O and 18F by proton irradiation of natural/enriched targets using cyclotrons. The development of PET has been hampered due to the size and shielding requirements of nuclear installations. Recent results show that when an intense laser beam interacts with solid targets, megaelectronvolt (MeV) protons capable of producing PET isotopes are generated. This report describes how to generate intense PET sources of 11C and 18F using a petawatt laser beam. The work describing the laser production of 18F through a (p,n) 18O reaction, and the subsequent synthesis of 2-[18F] is reported for the first time. The potential for developing compact laser technology for this purpose is discussed.",

keywords = "positron emission tomography, lasers, isotopes",

author = "K.W.D. Ledingham and P. McKenna and T. McCanny and S. Shimizu and J.M. Yang and L. Robson and J. Zweit and J.M. Gillies and J. Bailey and G.N. Chimon and R.J. Clarke and D. Neely and P.A. Norreys and J.L. Collier and R.P. Singhal and M.S. Wei and S.P.D. Mangles and P. Nilson and K. Krushelnick and M. Zepf",

year = "2004",

month = aug,

day = "21",

doi = "10.1088/0022-3727/37/16/019",

language = "English",

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Ledingham, KWD , McKenna, P , McCanny, T, Shimizu, S, Yang, JM, Robson, L, Zweit, J, Gillies, JM, Bailey, J, Chimon, GN, Clarke, RJ, Neely, D, Norreys, PA, Collier, JL, Singhal, RP, Wei, MS, Mangles, SPD, Nilson, P, Krushelnick, K & Zepf, M 2004, 'High power laser production of short-lived isotopes for positron emission tomography', Journal of Physics D: Applied Physics, vol. 37, no. 16, pp. 2341-2345. https://doi.org/10.1088/0022-3727/37/16/019

High power laser production of short-lived isotopes for positron emission tomography. / Ledingham, K.W.D.; McKenna, P.; McCanny, T.; Shimizu, S.; Yang, J.M.; Robson, L.; Zweit, J.; Gillies, J.M.; Bailey, J.; Chimon, G.N.; Clarke, R.J.; Neely, D.; Norreys, P.A.; Collier, J.L.; Singhal, R.P.; Wei, M.S.; Mangles, S.P.D.; Nilson, P.; Krushelnick, K.; Zepf, M.

In: Journal of Physics D: Applied Physics, Vol. 37, No. 16, 21.08.2004, p. 2341-2345.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - High power laser production of short-lived isotopes for positron emission tomography

AU - Ledingham, K.W.D.

AU - McKenna, P.

AU - McCanny, T.

AU - Shimizu, S.

AU - Yang, J.M.

AU - Robson, L.

AU - Zweit, J.

AU - Gillies, J.M.

AU - Bailey, J.

AU - Chimon, G.N.

AU - Clarke, R.J.

AU - Neely, D.

AU - Norreys, P.A.

AU - Collier, J.L.

AU - Singhal, R.P.

AU - Wei, M.S.

AU - Mangles, S.P.D.

AU - Nilson, P.

AU - Krushelnick, K.

AU - Zepf, M.

PY - 2004/8/21

Y1 - 2004/8/21

N2 - Positron emission tomography (PET) is a powerful diagnostic/imaging technique requiring the production of the short-lived positron emitting isotopes 11C, 13N, 15O and 18F by proton irradiation of natural/enriched targets using cyclotrons. The development of PET has been hampered due to the size and shielding requirements of nuclear installations. Recent results show that when an intense laser beam interacts with solid targets, megaelectronvolt (MeV) protons capable of producing PET isotopes are generated. This report describes how to generate intense PET sources of 11C and 18F using a petawatt laser beam. The work describing the laser production of 18F through a (p,n) 18O reaction, and the subsequent synthesis of 2-[18F] is reported for the first time. The potential for developing compact laser technology for this purpose is discussed.

AB - Positron emission tomography (PET) is a powerful diagnostic/imaging technique requiring the production of the short-lived positron emitting isotopes 11C, 13N, 15O and 18F by proton irradiation of natural/enriched targets using cyclotrons. The development of PET has been hampered due to the size and shielding requirements of nuclear installations. Recent results show that when an intense laser beam interacts with solid targets, megaelectronvolt (MeV) protons capable of producing PET isotopes are generated. This report describes how to generate intense PET sources of 11C and 18F using a petawatt laser beam. The work describing the laser production of 18F through a (p,n) 18O reaction, and the subsequent synthesis of 2-[18F] is reported for the first time. The potential for developing compact laser technology for this purpose is discussed.

KW - positron emission tomography

KW - lasers

KW - isotopes

U2 - 10.1088/0022-3727/37/16/019

DO - 10.1088/0022-3727/37/16/019

M3 - Article

VL - 37

SP - 2341

EP - 2345

JO - Journal of Physics D: Applied Physics

JF - Journal of Physics D: Applied Physics

SN - 0022-3727

IS - 16

ER -