HFC-134a as a fluorinated building block: short syntheses of α-fluoroenones

J Marie Bainbridge; Stuart Corr; Masatomi Kanai; Jonathan Percy

doi:10.1016/S0040-4039(99)02184-X

HFC-134a as a fluorinated building block: short syntheses of α-fluoroenones

J Marie Bainbridge, Stuart Corr, Masatomi Kanai, Jonathan Percy

Pure And Applied Chemistry

Research output: Contribution to journal › Article

24 Citations (Scopus)

Abstract

1,1,1,2-Tetrafluoroethane (HFC-134a) has been transformed into a range of -fluoroenones via a direct route. Dehydrofluorination/metallation allowed trifluorovinylsilanes to be prepared; these could be converted in situ, or isolated and treated further, with alkyllithium reagents to give difluorovinylsilanes. Fluoride-catalysed addition to aldehydes followed by acidic work-up allowed the isolation of a range of -fluoroenones in two- or three-pots.

Original language	English
Pages (from-to)	971–974
Number of pages	4
Journal	Tetrahedron Letters
Volume	41
Issue number	6
DOIs	https://doi.org/10.1016/S0040-4039(99)02184-X
Publication status	Published - 5 Feb 2000

Keywords

fluoroenones
aldehydes
trifluorovinylsilanes

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10.1016/S0040-4039(99)02184-X

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Bainbridge, J. M., Corr, S., Kanai, M., & Percy, J. (2000). HFC-134a as a fluorinated building block: short syntheses of α-fluoroenones. Tetrahedron Letters, 41(6), 971–974. https://doi.org/10.1016/S0040-4039(99)02184-X

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AU - Kanai, Masatomi

AU - Percy, Jonathan

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KW - fluoroenones

KW - aldehydes

KW - trifluorovinylsilanes

U2 - 10.1016/S0040-4039(99)02184-X

DO - 10.1016/S0040-4039(99)02184-X

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