Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 971–974 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 41 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 5 Feb 2000 |
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Keywords
- fluoroenones
- aldehydes
- trifluorovinylsilanes
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HFC-134a as a fluorinated building block : short syntheses of α-fluoroenones. / Bainbridge, J Marie; Corr, Stuart; Kanai, Masatomi; Percy, Jonathan.
In: Tetrahedron Letters, Vol. 41, No. 6, 05.02.2000, p. 971–974.Research output: Contribution to journal › Article
TY - JOUR
T1 - HFC-134a as a fluorinated building block
T2 - short syntheses of α-fluoroenones
AU - Bainbridge, J Marie
AU - Corr, Stuart
AU - Kanai, Masatomi
AU - Percy, Jonathan
PY - 2000/2/5
Y1 - 2000/2/5
N2 - 1,1,1,2-Tetrafluoroethane (HFC-134a) has been transformed into a range of -fluoroenones via a direct route. Dehydrofluorination/metallation allowed trifluorovinylsilanes to be prepared; these could be converted in situ, or isolated and treated further, with alkyllithium reagents to give difluorovinylsilanes. Fluoride-catalysed addition to aldehydes followed by acidic work-up allowed the isolation of a range of -fluoroenones in two- or three-pots.
AB - 1,1,1,2-Tetrafluoroethane (HFC-134a) has been transformed into a range of -fluoroenones via a direct route. Dehydrofluorination/metallation allowed trifluorovinylsilanes to be prepared; these could be converted in situ, or isolated and treated further, with alkyllithium reagents to give difluorovinylsilanes. Fluoride-catalysed addition to aldehydes followed by acidic work-up allowed the isolation of a range of -fluoroenones in two- or three-pots.
KW - fluoroenones
KW - aldehydes
KW - trifluorovinylsilanes
U2 - 10.1016/S0040-4039(99)02184-X
DO - 10.1016/S0040-4039(99)02184-X
M3 - Article
VL - 41
SP - 971
EP - 974
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 6
ER -