Hepatoprotective, antihyperglycemic and antidiabetic effects of Dendrophthoe pentandra leaf extract in rats

Mahadi Hasan, Mohammad Tuhin Ali, Rifat Khan, Parag Palit, Aminul Islam, Veronique Seidel, Rabeya Akter, Laizuman Nahar

Research output: Contribution to journalArticle

Abstract

Background: Dendrophthoe pentandra (L.) Miq. is a mistletoe species used in traditional medicine. Juice of leaves is used in wound healing, skin infection and cancer; whereas the whole plant is used to treat hypertension and cough. D. pentandra leaf extract has attracted interest due to its pharmacological properties including antioxidant, cytotoxicity and anti-inflammatory effects. In this study, we have investigated the hepatopotective, antihyperglycemic and antidiabetic potential of D. pentandra leaf extracts in rats. Methods: D. pentandra leaf methanolic extract (DPLME) at a fixed dose of 400 mg/kg body weight was evaluated for its effects on fasting glucose levels of rats. DPLME at the same dose was also used to determine the antidiabetic potential in alloxan-induced diabetic rats and the hepatopotective effects on Paracetamol (PCM) intoxicated rats. Results: Oral administration of DPLME exhibited a significantly notable oral glucose tolerance in rats. Single doses of the DPLME displayed very significant antidiabetic activity which was comparable to the activity of the standard antihyperglycemic agent Metformin (MET). DPLME also offered significant hepatoprotection to PCM-intoxicated rats at levels commensurable to the standard hepatoprotective drug Silymarin (SIL). Conclusions: The results of the present study showed that the DPLME possesses hepatopotective, antihyperglycemic and antidiabetic activity. All these results could be due to the presence of the bioactive components in the extract and this warrant further investigation on the nature of the phytochemical(s) responsible for the observed effects.
LanguageEnglish
Number of pages7
JournalClinical Phytoscience
Volume4
Issue number16
DOIs
Publication statusPublished - 26 Jun 2018

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Hypoglycemic Agents
Acetaminophen
Mistletoe
Silymarin
Alloxan
Metformin
Phytochemicals
Traditional Medicine
Skin Neoplasms
Glucose Tolerance Test
Cough
Wound Healing
Oral Administration
Fasting
Anti-Inflammatory Agents
Antioxidants
Body Weight
Pharmacology
Hypertension
Glucose

Keywords

  • Dendrophthoe pentandra
  • oral glucose tolerance test
  • antidiabetic activity
  • hepatoprotective activity

Cite this

Hasan, Mahadi ; Ali, Mohammad Tuhin ; Khan, Rifat ; Palit, Parag ; Islam, Aminul ; Seidel, Veronique ; Akter, Rabeya ; Nahar, Laizuman. / Hepatoprotective, antihyperglycemic and antidiabetic effects of Dendrophthoe pentandra leaf extract in rats. In: Clinical Phytoscience. 2018 ; Vol. 4, No. 16.
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abstract = "Background: Dendrophthoe pentandra (L.) Miq. is a mistletoe species used in traditional medicine. Juice of leaves is used in wound healing, skin infection and cancer; whereas the whole plant is used to treat hypertension and cough. D. pentandra leaf extract has attracted interest due to its pharmacological properties including antioxidant, cytotoxicity and anti-inflammatory effects. In this study, we have investigated the hepatopotective, antihyperglycemic and antidiabetic potential of D. pentandra leaf extracts in rats. Methods: D. pentandra leaf methanolic extract (DPLME) at a fixed dose of 400 mg/kg body weight was evaluated for its effects on fasting glucose levels of rats. DPLME at the same dose was also used to determine the antidiabetic potential in alloxan-induced diabetic rats and the hepatopotective effects on Paracetamol (PCM) intoxicated rats. Results: Oral administration of DPLME exhibited a significantly notable oral glucose tolerance in rats. Single doses of the DPLME displayed very significant antidiabetic activity which was comparable to the activity of the standard antihyperglycemic agent Metformin (MET). DPLME also offered significant hepatoprotection to PCM-intoxicated rats at levels commensurable to the standard hepatoprotective drug Silymarin (SIL). Conclusions: The results of the present study showed that the DPLME possesses hepatopotective, antihyperglycemic and antidiabetic activity. All these results could be due to the presence of the bioactive components in the extract and this warrant further investigation on the nature of the phytochemical(s) responsible for the observed effects.",
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Hepatoprotective, antihyperglycemic and antidiabetic effects of Dendrophthoe pentandra leaf extract in rats. / Hasan, Mahadi; Ali, Mohammad Tuhin; Khan, Rifat; Palit, Parag; Islam, Aminul; Seidel, Veronique; Akter, Rabeya; Nahar, Laizuman.

In: Clinical Phytoscience, Vol. 4, No. 16, 26.06.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Hepatoprotective, antihyperglycemic and antidiabetic effects of Dendrophthoe pentandra leaf extract in rats

AU - Hasan, Mahadi

AU - Ali, Mohammad Tuhin

AU - Khan, Rifat

AU - Palit, Parag

AU - Islam, Aminul

AU - Seidel, Veronique

AU - Akter, Rabeya

AU - Nahar, Laizuman

PY - 2018/6/26

Y1 - 2018/6/26

N2 - Background: Dendrophthoe pentandra (L.) Miq. is a mistletoe species used in traditional medicine. Juice of leaves is used in wound healing, skin infection and cancer; whereas the whole plant is used to treat hypertension and cough. D. pentandra leaf extract has attracted interest due to its pharmacological properties including antioxidant, cytotoxicity and anti-inflammatory effects. In this study, we have investigated the hepatopotective, antihyperglycemic and antidiabetic potential of D. pentandra leaf extracts in rats. Methods: D. pentandra leaf methanolic extract (DPLME) at a fixed dose of 400 mg/kg body weight was evaluated for its effects on fasting glucose levels of rats. DPLME at the same dose was also used to determine the antidiabetic potential in alloxan-induced diabetic rats and the hepatopotective effects on Paracetamol (PCM) intoxicated rats. Results: Oral administration of DPLME exhibited a significantly notable oral glucose tolerance in rats. Single doses of the DPLME displayed very significant antidiabetic activity which was comparable to the activity of the standard antihyperglycemic agent Metformin (MET). DPLME also offered significant hepatoprotection to PCM-intoxicated rats at levels commensurable to the standard hepatoprotective drug Silymarin (SIL). Conclusions: The results of the present study showed that the DPLME possesses hepatopotective, antihyperglycemic and antidiabetic activity. All these results could be due to the presence of the bioactive components in the extract and this warrant further investigation on the nature of the phytochemical(s) responsible for the observed effects.

AB - Background: Dendrophthoe pentandra (L.) Miq. is a mistletoe species used in traditional medicine. Juice of leaves is used in wound healing, skin infection and cancer; whereas the whole plant is used to treat hypertension and cough. D. pentandra leaf extract has attracted interest due to its pharmacological properties including antioxidant, cytotoxicity and anti-inflammatory effects. In this study, we have investigated the hepatopotective, antihyperglycemic and antidiabetic potential of D. pentandra leaf extracts in rats. Methods: D. pentandra leaf methanolic extract (DPLME) at a fixed dose of 400 mg/kg body weight was evaluated for its effects on fasting glucose levels of rats. DPLME at the same dose was also used to determine the antidiabetic potential in alloxan-induced diabetic rats and the hepatopotective effects on Paracetamol (PCM) intoxicated rats. Results: Oral administration of DPLME exhibited a significantly notable oral glucose tolerance in rats. Single doses of the DPLME displayed very significant antidiabetic activity which was comparable to the activity of the standard antihyperglycemic agent Metformin (MET). DPLME also offered significant hepatoprotection to PCM-intoxicated rats at levels commensurable to the standard hepatoprotective drug Silymarin (SIL). Conclusions: The results of the present study showed that the DPLME possesses hepatopotective, antihyperglycemic and antidiabetic activity. All these results could be due to the presence of the bioactive components in the extract and this warrant further investigation on the nature of the phytochemical(s) responsible for the observed effects.

KW - Dendrophthoe pentandra

KW - oral glucose tolerance test

KW - antidiabetic activity

KW - hepatoprotective activity

U2 - 10.1186/s40816-018-0076-9

DO - 10.1186/s40816-018-0076-9

M3 - Article

VL - 4

JO - Clinical Phytoscience

T2 - Clinical Phytoscience

JF - Clinical Phytoscience

SN - 2199-1197

IS - 16

ER -