Hepatoprotective, antihyperglycemic and antidiabetic effects of Dendrophthoe pentandra leaf extract in rats

Mahadi Hasan, Mohammad Tuhin Ali, Rifat Khan, Parag Palit, Aminul Islam, Veronique Seidel, Rabeya Akter, Laizuman Nahar

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Abstract

Background: Dendrophthoe pentandra (L.) Miq. is a mistletoe species used in traditional medicine. Juice of leaves is used in wound healing, skin infection and cancer; whereas the whole plant is used to treat hypertension and cough. D. pentandra leaf extract has attracted interest due to its pharmacological properties including antioxidant, cytotoxicity and anti-inflammatory effects. In this study, we have investigated the hepatopotective, antihyperglycemic and antidiabetic potential of D. pentandra leaf extracts in rats. Methods: D. pentandra leaf methanolic extract (DPLME) at a fixed dose of 400 mg/kg body weight was evaluated for its effects on fasting glucose levels of rats. DPLME at the same dose was also used to determine the antidiabetic potential in alloxan-induced diabetic rats and the hepatopotective effects on Paracetamol (PCM) intoxicated rats. Results: Oral administration of DPLME exhibited a significantly notable oral glucose tolerance in rats. Single doses of the DPLME displayed very significant antidiabetic activity which was comparable to the activity of the standard antihyperglycemic agent Metformin (MET). DPLME also offered significant hepatoprotection to PCM-intoxicated rats at levels commensurable to the standard hepatoprotective drug Silymarin (SIL). Conclusions: The results of the present study showed that the DPLME possesses hepatopotective, antihyperglycemic and antidiabetic activity. All these results could be due to the presence of the bioactive components in the extract and this warrant further investigation on the nature of the phytochemical(s) responsible for the observed effects.
Original languageEnglish
Number of pages7
JournalClinical Phytoscience
Volume4
Issue number16
DOIs
Publication statusPublished - 26 Jun 2018

Keywords

  • Dendrophthoe pentandra
  • oral glucose tolerance test
  • antidiabetic activity
  • hepatoprotective activity

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