Hepatocellular damage following therapeutic intravenous iron sucrose infusion in a child

D.M. Wood, Alison Thomson, M Lawes, A.L. Jones, P. Dargan

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The maximum tolerated single dose of intravenous iron infusion and iron pharmacokinetics are not known in children and not clear in adults. The case reported here is of a child given a large dose of intravenous iron sucrose (16 mg/kg) over 3 hours, who subsequently developed features of systemic iron toxicity. A TDM consultant discusses the case in the context of toxicokinetic analysis. Because the maximum tolerated dose and pharmacokinetics of intravenous iron preparations are not known, their use in both adults and children should still be undertaken with caution.
Original languageEnglish
Pages (from-to)405-408
Number of pages4
JournalTherapeutic Drug Monitoring
Volume27
Issue number4
DOIs
Publication statusPublished - Aug 2005

Keywords

  • hepatocellular damage
  • intravenous iron sucrose
  • iron toxicity
  • toxicokinetic analysis

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