Hepatitis C virus among childbearing women in Scotland: prevalence, deprivation and diagnosis

S. Hutchinson, D.J. Goldberg, M. King, S.O. Cameron, L.E. Shaw, A. Brown, J. MacKenzie, K. Wilson, L. MacDonald

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

To examine the prevalence and demographic characteristics of hepatitis C virus (HCV) infection among childbearing women in Scotland; and (B) to determine the extent of maternal HCV infection diagnosed prior to birth. (A) Residual dried blood spot samples from routine neonatal screening, collected throughout Scotland during March-October 2000, were unlinked from identifiers and tested anonymously for HCV antibodies; and (B) electronic record linkage of Scotland’s databases of births and diagnosed HCV infections was performed. (A) Of 30 259 samples, 121 were enzyme linked immunosorbent assay repeat reactive and 88 of these were confirmed as anti-HCV positive in the recombinant immunoblot assay, representing a seroprevalence of 0.29–0.40%. HCV seroprevalence was high among 25–29 year olds (0.4–0.57%), in high deprivation areas (0.92–1.07%), and in Greater Glasgow (0.83–0.96%) and Grampian (0.38–0.62%). Adjusted relative risk for HCV infection was highest among residents in high deprivation areas of Glasgow (7.2 (95% confidence interval 2.0–25.5)). (B) Of 121 HCV infections found among women at delivery, 24% and 46% were estimated to have been diagnosed prior to pregnancy and birth, respectively. HCV prevalence among Scottish childbearing women is consistent with that expected from injecting drug use. Based on reported rates of mother to child transmission, 8–11 paediatric infections are expected per annum. Diagnosis in only 24% of infected women prior to pregnancy indicates the extent to which HCV goes unrecognised in the injecting community. The current HCV screening approach—to test only those with a history of injecting drug use (or other risk factors for infection)—identifies approximately a quarter of previously undetected infections among pregnant women.
LanguageEnglish
Pages593-598
Number of pages6
JournalGut
Volume53
DOIs
Publication statusPublished - 2004

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Scotland
Hepacivirus
Virus Diseases
Seroepidemiologic Studies
Parturition
Infection
Mothers
Neonatal Screening
Pregnancy
Hepatitis C Antibodies
Pharmaceutical Preparations
Pregnant Women
Enzyme-Linked Immunosorbent Assay
Demography
Databases
Confidence Intervals
Pediatrics

Keywords

  • childbearing
  • hepatitis c virus

Cite this

Hutchinson, S., Goldberg, D. J., King, M., Cameron, S. O., Shaw, L. E., Brown, A., ... MacDonald, L. (2004). Hepatitis C virus among childbearing women in Scotland: prevalence, deprivation and diagnosis. Gut, 53, 593-598. https://doi.org/10.1136/gut.2003.027383
Hutchinson, S. ; Goldberg, D.J. ; King, M. ; Cameron, S.O. ; Shaw, L.E. ; Brown, A. ; MacKenzie, J. ; Wilson, K. ; MacDonald, L. / Hepatitis C virus among childbearing women in Scotland: prevalence, deprivation and diagnosis. In: Gut. 2004 ; Vol. 53. pp. 593-598.
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abstract = "To examine the prevalence and demographic characteristics of hepatitis C virus (HCV) infection among childbearing women in Scotland; and (B) to determine the extent of maternal HCV infection diagnosed prior to birth. (A) Residual dried blood spot samples from routine neonatal screening, collected throughout Scotland during March-October 2000, were unlinked from identifiers and tested anonymously for HCV antibodies; and (B) electronic record linkage of Scotland’s databases of births and diagnosed HCV infections was performed. (A) Of 30 259 samples, 121 were enzyme linked immunosorbent assay repeat reactive and 88 of these were confirmed as anti-HCV positive in the recombinant immunoblot assay, representing a seroprevalence of 0.29–0.40{\%}. HCV seroprevalence was high among 25–29 year olds (0.4–0.57{\%}), in high deprivation areas (0.92–1.07{\%}), and in Greater Glasgow (0.83–0.96{\%}) and Grampian (0.38–0.62{\%}). Adjusted relative risk for HCV infection was highest among residents in high deprivation areas of Glasgow (7.2 (95{\%} confidence interval 2.0–25.5)). (B) Of 121 HCV infections found among women at delivery, 24{\%} and 46{\%} were estimated to have been diagnosed prior to pregnancy and birth, respectively. HCV prevalence among Scottish childbearing women is consistent with that expected from injecting drug use. Based on reported rates of mother to child transmission, 8–11 paediatric infections are expected per annum. Diagnosis in only 24{\%} of infected women prior to pregnancy indicates the extent to which HCV goes unrecognised in the injecting community. The current HCV screening approach—to test only those with a history of injecting drug use (or other risk factors for infection)—identifies approximately a quarter of previously undetected infections among pregnant women.",
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Hutchinson, S, Goldberg, DJ, King, M, Cameron, SO, Shaw, LE, Brown, A, MacKenzie, J, Wilson, K & MacDonald, L 2004, 'Hepatitis C virus among childbearing women in Scotland: prevalence, deprivation and diagnosis' Gut, vol. 53, pp. 593-598. https://doi.org/10.1136/gut.2003.027383

Hepatitis C virus among childbearing women in Scotland: prevalence, deprivation and diagnosis. / Hutchinson, S.; Goldberg, D.J.; King, M.; Cameron, S.O.; Shaw, L.E.; Brown, A.; MacKenzie, J.; Wilson, K.; MacDonald, L.

In: Gut, Vol. 53, 2004, p. 593-598.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Hepatitis C virus among childbearing women in Scotland: prevalence, deprivation and diagnosis

AU - Hutchinson, S.

AU - Goldberg, D.J.

AU - King, M.

AU - Cameron, S.O.

AU - Shaw, L.E.

AU - Brown, A.

AU - MacKenzie, J.

AU - Wilson, K.

AU - MacDonald, L.

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N2 - To examine the prevalence and demographic characteristics of hepatitis C virus (HCV) infection among childbearing women in Scotland; and (B) to determine the extent of maternal HCV infection diagnosed prior to birth. (A) Residual dried blood spot samples from routine neonatal screening, collected throughout Scotland during March-October 2000, were unlinked from identifiers and tested anonymously for HCV antibodies; and (B) electronic record linkage of Scotland’s databases of births and diagnosed HCV infections was performed. (A) Of 30 259 samples, 121 were enzyme linked immunosorbent assay repeat reactive and 88 of these were confirmed as anti-HCV positive in the recombinant immunoblot assay, representing a seroprevalence of 0.29–0.40%. HCV seroprevalence was high among 25–29 year olds (0.4–0.57%), in high deprivation areas (0.92–1.07%), and in Greater Glasgow (0.83–0.96%) and Grampian (0.38–0.62%). Adjusted relative risk for HCV infection was highest among residents in high deprivation areas of Glasgow (7.2 (95% confidence interval 2.0–25.5)). (B) Of 121 HCV infections found among women at delivery, 24% and 46% were estimated to have been diagnosed prior to pregnancy and birth, respectively. HCV prevalence among Scottish childbearing women is consistent with that expected from injecting drug use. Based on reported rates of mother to child transmission, 8–11 paediatric infections are expected per annum. Diagnosis in only 24% of infected women prior to pregnancy indicates the extent to which HCV goes unrecognised in the injecting community. The current HCV screening approach—to test only those with a history of injecting drug use (or other risk factors for infection)—identifies approximately a quarter of previously undetected infections among pregnant women.

AB - To examine the prevalence and demographic characteristics of hepatitis C virus (HCV) infection among childbearing women in Scotland; and (B) to determine the extent of maternal HCV infection diagnosed prior to birth. (A) Residual dried blood spot samples from routine neonatal screening, collected throughout Scotland during March-October 2000, were unlinked from identifiers and tested anonymously for HCV antibodies; and (B) electronic record linkage of Scotland’s databases of births and diagnosed HCV infections was performed. (A) Of 30 259 samples, 121 were enzyme linked immunosorbent assay repeat reactive and 88 of these were confirmed as anti-HCV positive in the recombinant immunoblot assay, representing a seroprevalence of 0.29–0.40%. HCV seroprevalence was high among 25–29 year olds (0.4–0.57%), in high deprivation areas (0.92–1.07%), and in Greater Glasgow (0.83–0.96%) and Grampian (0.38–0.62%). Adjusted relative risk for HCV infection was highest among residents in high deprivation areas of Glasgow (7.2 (95% confidence interval 2.0–25.5)). (B) Of 121 HCV infections found among women at delivery, 24% and 46% were estimated to have been diagnosed prior to pregnancy and birth, respectively. HCV prevalence among Scottish childbearing women is consistent with that expected from injecting drug use. Based on reported rates of mother to child transmission, 8–11 paediatric infections are expected per annum. Diagnosis in only 24% of infected women prior to pregnancy indicates the extent to which HCV goes unrecognised in the injecting community. The current HCV screening approach—to test only those with a history of injecting drug use (or other risk factors for infection)—identifies approximately a quarter of previously undetected infections among pregnant women.

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KW - hepatitis c virus

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DO - 10.1136/gut.2003.027383

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Hutchinson S, Goldberg DJ, King M, Cameron SO, Shaw LE, Brown A et al. Hepatitis C virus among childbearing women in Scotland: prevalence, deprivation and diagnosis. Gut. 2004;53:593-598. https://doi.org/10.1136/gut.2003.027383