Helminth-derived immunomodulators: can understanding the worm produce the pill?

W. Harnett, M.M. Harnett

Research output: Contribution to journalArticle

142 Citations (Scopus)

Abstract

Helminths may protect humans against allergic and autoimmune diseases and, indeed, defined helminth-derived products have recently been shown to prevent the development of such inflammatory diseases in mouse models. Here, we propose that helminth-derived products not only have therapeutic potential but can also be used as unique tools for defining key molecular events in the induction of an anti-inflammatory response and, therefore, for defining new therapeutic targets.
Original languageEnglish
Pages (from-to)278-284
Number of pages7
JournalNature Reviews Immunology
Volume10
Issue number4
DOIs
Publication statusPublished - Apr 2010

Keywords

  • dentritic cell activation
  • containing secreted product
  • host immune-responses
  • drives TH2 responses
  • toll-like receptors
  • c-type lectins
  • protein kinase
  • in-vivo
  • inflammatory responses

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