Abstract
Helminths may protect humans against allergic and autoimmune diseases and, indeed, defined helminth-derived products have recently been shown to prevent the development of such inflammatory diseases in mouse models. Here, we propose that helminth-derived products not only have therapeutic potential but can also be used as unique tools for defining key molecular events in the induction of an anti-inflammatory response and, therefore, for defining new therapeutic targets.
| Original language | English |
|---|---|
| Pages (from-to) | 278-284 |
| Number of pages | 7 |
| Journal | Nature Reviews Immunology |
| Volume | 10 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2010 |
Keywords
- dentritic cell activation
- containing secreted product
- host immune-responses
- drives TH2 responses
- toll-like receptors
- c-type lectins
- protein kinase
- in-vivo
- inflammatory responses