Haemodynamic analysis in arterial models in relation to pulmonary valve treatment in adults with congenital heart disease

Research output: Contribution to conferenceAbstract

Abstract

Introduction Pulmonary artery stenting and valve replacement (PVR) are common interventions in an increasing population of adult patients with previously repaired congenital heart disease [1]. Indications for intervention include assessing regional haemodynamics and effects on right ventricular volume and function [2]. The criterion for intervention remains largely empirical and the optimal timing remains unknown. This work aims to investigate the altered haemodynamic environment of adults with congenital heart disease, pre- and post- operative PVR to establish a computational fluid dynamic (CFD) derived metric for determining the optimal requirement for PVR and stenting. In this initial work, we present CFD results in simplified geometries representing the proximal pulmonary artery and bifurcation. Methods Blood flow simulations were performed using an implementation of the finite volume method. The flow was assumed to be incompressible and governed by the Newtonian Navier-Stokes equations. Physiological vessel dimensions and boundary conditions were used in the models. Local velocities and wall shear stress values were evaluated numerically. Results and Discussion Blood flow in the pulmonary bifurcation is strongly dependent on the local geometrical characteristics and haemodynamic conditions. An increase in the flow separation is observed when the angle of the bifurcation increases. In addition, the geometry has a significant effect on the velocities and shear stresses developed on the vessel wall. Future work will involve anatomically-correct reconstructions from CT and MRI image data of adult congenital heart patients that have or are about to undergo pulmonary valve replacement. Numerical studies of these models will provide an insight into the underlying flow mechanisms of more complex 3D patient-specific geometries.

Conference

Conference13th World Congress in Computational Mechanics
CountryUnited States
CityNew York
Period22/07/1827/07/18
Internet address

Fingerprint

Pulmonary Valve
Hemodynamics
Heart Diseases
Bifurcation (mathematics)
Hydrodynamics
Pulmonary Artery
Geometry
Shear stress
Computational fluid dynamics
Blood
Right Ventricular Function
Flow separation
Flow simulation
Finite volume method
Magnetic resonance imaging
Navier Stokes equations
Therapeutics
Boundary conditions
Lung
Population

Keywords

  • pulmonary valve replacement
  • congenital heart disease
  • haemodynamic analysis
  • haemodynamic environment

Cite this

@conference{2b1c1683b96045ee977eb38dba7a9d56,
title = "Haemodynamic analysis in arterial models in relation to pulmonary valve treatment in adults with congenital heart disease",
abstract = "Introduction Pulmonary artery stenting and valve replacement (PVR) are common interventions in an increasing population of adult patients with previously repaired congenital heart disease [1]. Indications for intervention include assessing regional haemodynamics and effects on right ventricular volume and function [2]. The criterion for intervention remains largely empirical and the optimal timing remains unknown. This work aims to investigate the altered haemodynamic environment of adults with congenital heart disease, pre- and post- operative PVR to establish a computational fluid dynamic (CFD) derived metric for determining the optimal requirement for PVR and stenting. In this initial work, we present CFD results in simplified geometries representing the proximal pulmonary artery and bifurcation. Methods Blood flow simulations were performed using an implementation of the finite volume method. The flow was assumed to be incompressible and governed by the Newtonian Navier-Stokes equations. Physiological vessel dimensions and boundary conditions were used in the models. Local velocities and wall shear stress values were evaluated numerically. Results and Discussion Blood flow in the pulmonary bifurcation is strongly dependent on the local geometrical characteristics and haemodynamic conditions. An increase in the flow separation is observed when the angle of the bifurcation increases. In addition, the geometry has a significant effect on the velocities and shear stresses developed on the vessel wall. Future work will involve anatomically-correct reconstructions from CT and MRI image data of adult congenital heart patients that have or are about to undergo pulmonary valve replacement. Numerical studies of these models will provide an insight into the underlying flow mechanisms of more complex 3D patient-specific geometries.",
keywords = "pulmonary valve replacement, congenital heart disease, haemodynamic analysis, haemodynamic environment",
author = "Maria Boumpouli and Mark Danton and Terence Gourlay and Asimina Kazakidi",
year = "2018",
month = "7",
day = "22",
language = "English",
note = "13th World Congress in Computational Mechanics ; Conference date: 22-07-2018 Through 27-07-2018",
url = "http://www.wccm2018.org/",

}

Haemodynamic analysis in arterial models in relation to pulmonary valve treatment in adults with congenital heart disease. / Boumpouli, Maria; Danton, Mark; Gourlay, Terence; Kazakidi, Asimina.

2018. Abstract from 13th World Congress in Computational Mechanics, New York, United States.

Research output: Contribution to conferenceAbstract

TY - CONF

T1 - Haemodynamic analysis in arterial models in relation to pulmonary valve treatment in adults with congenital heart disease

AU - Boumpouli, Maria

AU - Danton, Mark

AU - Gourlay, Terence

AU - Kazakidi, Asimina

PY - 2018/7/22

Y1 - 2018/7/22

N2 - Introduction Pulmonary artery stenting and valve replacement (PVR) are common interventions in an increasing population of adult patients with previously repaired congenital heart disease [1]. Indications for intervention include assessing regional haemodynamics and effects on right ventricular volume and function [2]. The criterion for intervention remains largely empirical and the optimal timing remains unknown. This work aims to investigate the altered haemodynamic environment of adults with congenital heart disease, pre- and post- operative PVR to establish a computational fluid dynamic (CFD) derived metric for determining the optimal requirement for PVR and stenting. In this initial work, we present CFD results in simplified geometries representing the proximal pulmonary artery and bifurcation. Methods Blood flow simulations were performed using an implementation of the finite volume method. The flow was assumed to be incompressible and governed by the Newtonian Navier-Stokes equations. Physiological vessel dimensions and boundary conditions were used in the models. Local velocities and wall shear stress values were evaluated numerically. Results and Discussion Blood flow in the pulmonary bifurcation is strongly dependent on the local geometrical characteristics and haemodynamic conditions. An increase in the flow separation is observed when the angle of the bifurcation increases. In addition, the geometry has a significant effect on the velocities and shear stresses developed on the vessel wall. Future work will involve anatomically-correct reconstructions from CT and MRI image data of adult congenital heart patients that have or are about to undergo pulmonary valve replacement. Numerical studies of these models will provide an insight into the underlying flow mechanisms of more complex 3D patient-specific geometries.

AB - Introduction Pulmonary artery stenting and valve replacement (PVR) are common interventions in an increasing population of adult patients with previously repaired congenital heart disease [1]. Indications for intervention include assessing regional haemodynamics and effects on right ventricular volume and function [2]. The criterion for intervention remains largely empirical and the optimal timing remains unknown. This work aims to investigate the altered haemodynamic environment of adults with congenital heart disease, pre- and post- operative PVR to establish a computational fluid dynamic (CFD) derived metric for determining the optimal requirement for PVR and stenting. In this initial work, we present CFD results in simplified geometries representing the proximal pulmonary artery and bifurcation. Methods Blood flow simulations were performed using an implementation of the finite volume method. The flow was assumed to be incompressible and governed by the Newtonian Navier-Stokes equations. Physiological vessel dimensions and boundary conditions were used in the models. Local velocities and wall shear stress values were evaluated numerically. Results and Discussion Blood flow in the pulmonary bifurcation is strongly dependent on the local geometrical characteristics and haemodynamic conditions. An increase in the flow separation is observed when the angle of the bifurcation increases. In addition, the geometry has a significant effect on the velocities and shear stresses developed on the vessel wall. Future work will involve anatomically-correct reconstructions from CT and MRI image data of adult congenital heart patients that have or are about to undergo pulmonary valve replacement. Numerical studies of these models will provide an insight into the underlying flow mechanisms of more complex 3D patient-specific geometries.

KW - pulmonary valve replacement

KW - congenital heart disease

KW - haemodynamic analysis

KW - haemodynamic environment

UR - http://www.wccm2018.org/

M3 - Abstract

ER -