Guiding principles for peptide nanotechnology through directed discovery

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

Life's diverse molecular functions are largely based on only a small number of highly conserved building blocks-the twenty canonical amino acids. These building blocks are chemically simple, but when they are organized in three-dimensional structures of tremendous complexity, new properties emerge. This review explores recent efforts in the directed discovery of functional nanoscale systems and materials based on these same amino acids, but that are not guided by copying or editing biological systems. The review summarises insights obtained using three complementary approaches of searching the sequence space to explore sequence-structure relationships for assembly, reactivity and complexation, namely: (i) strategic editing of short peptide sequences; (ii) computational approaches to predicting and comparing assembly behaviours; (iii) dynamic peptide libraries that explore the free energy landscape. These approaches give rise to guiding principles on controlling order/disorder, complexation and reactivity by peptide sequence design.

LanguageEnglish
Pages3737-3758
Number of pages22
JournalChemical Society Reviews
Volume47
Issue number10
Early online date11 May 2018
DOIs
Publication statusPublished - 21 May 2018

Fingerprint

Complexation
Nanotechnology
Amino Acids
Peptide Library
Peptides
Copying
Order disorder transitions
Biological systems
Free energy

Keywords

  • amino acids
  • sequence-structure relationships
  • short peptide sequences

Cite this

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title = "Guiding principles for peptide nanotechnology through directed discovery",
abstract = "Life's diverse molecular functions are largely based on only a small number of highly conserved building blocks-the twenty canonical amino acids. These building blocks are chemically simple, but when they are organized in three-dimensional structures of tremendous complexity, new properties emerge. This review explores recent efforts in the directed discovery of functional nanoscale systems and materials based on these same amino acids, but that are not guided by copying or editing biological systems. The review summarises insights obtained using three complementary approaches of searching the sequence space to explore sequence-structure relationships for assembly, reactivity and complexation, namely: (i) strategic editing of short peptide sequences; (ii) computational approaches to predicting and comparing assembly behaviours; (iii) dynamic peptide libraries that explore the free energy landscape. These approaches give rise to guiding principles on controlling order/disorder, complexation and reactivity by peptide sequence design.",
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Guiding principles for peptide nanotechnology through directed discovery. / Lampel, A.; Ulijn, R. V.; Tuttle, T.

In: Chemical Society Reviews, Vol. 47, No. 10, 21.05.2018, p. 3737-3758.

Research output: Contribution to journalReview article

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AU - Lampel, A.

AU - Ulijn, R. V.

AU - Tuttle, T.

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