A new acetogenin, trivial name goniothalamusin, has been isolated from the aerial parts of Goniothalamus gardneri (Annonaceae). Goniothalamusin is a linear acetylenic and olefinic acetogenin with a C25 skeleton, lacking oxygenated substituents on its alkyl chain and with a new type of saturated γ-hydroxymethyl-γ-lactone terminal ring. Its structure and relative stereochemistry established as rel-24α-hydroxymethyl-2β-eicosa-21-en-13-yn-tetrahydrofuran-1-one has been elucidated by spectroscopic analysis.
- Goniothalamus gardneri
- linear acetogenin