Abstract
Reactions of Au(III) with biomolecules are of interest in relation to understanding the mechanism of action of therapeutic gold compounds. NMR investigations of 13C and 15N isotopically-labelled glycine and alanine show that Au(III) induces deamination and subsequent decarboxylation of both amino acids with the same mechanism. For comparison, reactions of Au(III) with sarcosine and the dicarboxylic acid malonic acid were also investigated. The major intermediates and products have been identified.
| Original language | English |
|---|---|
| Pages (from-to) | 499-504 |
| Number of pages | 6 |
| Journal | Journal of the Chinese Chemical Society |
| Volume | 49 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1 Aug 2002 |
Funding
We thank the Wellcome Trust (Travelling Fellowship to JZ, and Edinburgh Protein Interaction Centre) and EPSRC for their support for this work
Keywords
- gold(III) complex
- amino acid
- malonic acid
- NMR spectroscopy
- isotope labelling
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